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1.
Med Sci Law ; 63(2): 132-139, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35957596

RESUMO

Guidelines from the Netherlands describe that unnatural deaths should be investigated by a forensic physician and Crime Scene Technicians, but this is not always the case. In this study, we aimed to determine what predicts the non-attendance of the Crime Scene Technicians at the scene of the death of suicides in the police region in Rotterdam, the Netherlands. Data of 315 suicides (2016-2017) that have been externally examined by forensic physicians and reports from the Crime Scene Technicians were analysed. Statistical analysis was performed to determine the factors predicting the involvement of the Crime Scene Technicians at the scene of death. The Crime Scene Technicians were not attending in 23% (n = 72) cases, and over half of these cases were not found in the registration system of the Crime Scene Technicians. About some the Crime Scene Technicians was not informed. Predictors of the non-attendance of the Crime Scene Technicians were suicide by poisoning, the individual was found by an acquaintance or family, a history of suicide attempts and examination of the deceased in the hospital. In this study, we observed that the Crime Scene Technicians were sometimes not attending the investigation of apparent suicides. More research on this topic should be done to investigate the value of the presence of the Crime Scene Technicians at the scene before concluding that non-attendance of Crime Scene Technicians on-site influences the quality of the scene of death investigation and corresponding conclusions. Since 2017, several quality improvements were made, but an (inter)national conjoint protocol for uniform and structural suicide investigation could secure the quality of the scene of death investigation of suicides and would provide information useful for evaluation.


Assuntos
Medicina Legal , Ideação Suicida , Humanos , Países Baixos/epidemiologia , Crime , Tentativa de Suicídio
2.
J Forensic Leg Med ; 88: 102346, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35417849

RESUMO

Forensic physicians in the region of Amsterdam routinely collect blood and urine samples during external examinations. A rapid on-site multidrug test is used to screen the urine samples for the presence of commonly used drugs classes. Urine and blood samples are sent to the laboratory for additional toxicological analysis. This study aimed to investigate how the substances found in urine using the on-site multidrug test relate to the substances identified with laboratory methods. In 2018 and 2019, 465 cases underwent an on-site multidrug test as well as toxicological laboratory analyses and were included in this study. Fifty-three percent (n = 247) of these cases included a positive on-site multidrug test for at least one substance. The level of total agreement between the on-site multidrug test performed by the forensic physician and the laboratory analyses either in urine or in blood varied per substance groups, with the best results for barbiturates, cocaine, ecstasy and methadone. In conclusion, the on-site multidrug test appeared to perform well for certain substance groups and is an economical and rapid tool. However, the results from the laboratory analyses in blood occasionally provided additional insights concerning the circumstances that could be of importance in the cause of death.


Assuntos
Médicos , Detecção do Abuso de Substâncias , Causas de Morte , Toxicologia Forense/métodos , Humanos , Metadona , Detecção do Abuso de Substâncias/métodos
3.
BMC Public Health ; 11: 190, 2011 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-21443761

RESUMO

BACKGROUND: As in many European countries, access to care is decreased for undocumented migrants in the Netherlands due to legislation. Studies on the health of undocumented migrants in Europe are scarce and focus on care-seeking migrants. Not much is known on those who do not seek care. METHODS: This cross-sectional study includes both respondents who did and did not seek care, namely undocumented migrants who have been incarcerated in a detention centre while awaiting expulsion to their country of origin. A consecutive sample of all new arrivals was studied. Data were collected through structured interviews and reviews of medical records. RESULTS: Among the 224 male migrants who arrived at the detention centre between May and July 2008, 173 persons were interviewed. 122 respondents met inclusion criteria. Only half of the undocumented migrants in this study knew how to get access to medical care in the Netherlands if in need. Forty-six percent of respondents reported to have sought medical help during their stay in the Netherlands while having no health insurance (n = 57). Care was sought most frequently for injuries and dental problems. About 25% of these care seekers reported to have been denied care by a health care provider. Asian migrants were significantly less likely to seek care when compared to other ethnic groups, independent from age, chronic health problems and length of stay in the Netherlands. CONCLUSION: The study underlines the need for a better education of undocumented patients and providers concerning the opportunities for health care in the Netherlands. Moreover, there is a need to further clarify the reasons for the denial of care to undocumented patients, as well as the barriers to health care as perceived by undocumented migrants.


Assuntos
Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Migrantes/estatística & dados numéricos , Adulto , Estudos Transversais , Conhecimentos, Atitudes e Prática em Saúde , Acessibilidade aos Serviços de Saúde/legislação & jurisprudência , Acessibilidade aos Serviços de Saúde/estatística & dados numéricos , Humanos , Masculino , Países Baixos , Pesquisa Qualitativa , Recusa em Tratar/estatística & dados numéricos , Migrantes/legislação & jurisprudência , Migrantes/psicologia
4.
Forensic Sci Int ; 318: 110566, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33168418

RESUMO

INTRODUCTION: In 2012 and 2013 a movie and a book about a 'dignified end of life' were published in the Netherlands. These items described suicide using an 'exit bag' to establish asphyxiation using helium (the helium method). 'Right-to-die-organisations' inform the elderly about this method. The purpose of this study is to investigate whether the use of suicidal asphyxiation by means of the helium method substituted other, related, methods following its publication in the Netherlands. MATERIAL AND METHODS: We analysed suicides in the Netherlands over the period from 1 July 2012 to 30 June 2019. We compared the number of deaths caused by the helium method with other, related, cases. Secondly, we related these deaths to the total number of inhabitants and suicides recorded by Statistics Netherlands. RESULTS: The study showed a stable trend in the use of the helium method in the period 2012-2019 and this was the same for the other, related methods. Individuals using the helium method were significantly younger than those using other, related, methods. At the scene of death, information about suicide and suicide notes were found more often at 'helium method' cases than with the 'other, related, methods' cases. Family was significantly more often present during a helium method suicide than during suicide by other, related, methods. DISCUSSION: The number of suicides by the helium method and other, related, cases is stable in the Netherlands over the past years. Therefore, we conclude that there is no substitution effect within this category of suicides. Whilst 'right-to-die-organisations' strive to inform the old and sick of the helium method, it is noteworthy that the individuals using the helium method are significantly younger than the individuals who choose other, related, methods.


Assuntos
Asfixia/mortalidade , Hélio/intoxicação , Suicídio Consumado/estatística & dados numéricos , Administração por Inalação , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Países Baixos/epidemiologia , Estudos Retrospectivos , Distribuição por Sexo , Adulto Jovem
5.
Ned Tijdschr Geneeskd ; 1642020 06 17.
Artigo em Holandês | MEDLINE | ID: mdl-32749794

RESUMO

Euthanasia is legal in the Netherlands. Nevertheless, some individuals decide to plan their self-chosen death without the help of a physician. 'Right-to-die' organisations provide advice about humane deaths, which include voluntary refusal of food and fluids, the helium method and use of a lethal overdose of medication. It is known that suicides are sometimes influenced by the media and internet. Since 2013, 'right-to-die' organisations have informed individuals about the use of a deadly barbiturate overdose and the helium method. A rise in suicides resulting from these methods has subsequently been observed in the Netherlands. Suicides are recorded as deaths resulting from unnatural causes and are therefore investigated by a forensic physician, forensic investigator and tactical investigator. Investigation should determine the cause of death and rule out a staged crime, 'criminal' assisted suicide or an accident.


Assuntos
Eutanásia/ética , Medicina Legal/ética , Direito a Morrer , Suicídio Assistido/ética , Causas de Morte , Eutanásia/legislação & jurisprudência , Humanos , Países Baixos , Suicídio Assistido/legislação & jurisprudência
6.
J Forensic Leg Med ; 70: 101916, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32090971

RESUMO

INTRODUCTION: The three 'advised' suicide methods are helium asphyxiation, voluntarily stop eating and drinking and the use of a deadly dose of medication such as barbiturates. The aim of this study was to analyse the number of suicides resulting from barbiturate overdose and examine the influence of publications and internet on this suicide method in the two larger cities of the Netherlands. METHODS: Data of suicides by medication and drugs overdose were extracted from the electronic registration systems of the forensic physicians of the district of Amsterdam and Rotterdam over the period 1 January 2006-31 December 2017. We analysed whether or not the number of suicides using barbiturate overdose has significantly risen since 2013. This was the year 'right-to-die-organisations' informed individuals about this method and a book was published describing this as a humane death. In addition, a regression analysis was used to examine which factors predict a suicide resulting from barbiturate overdose. RESULTS: A total of 553 overdose suicides were identified and 91 suicides resulting from barbiturate overdose were included for further evaluation. During 2013-2017 there were significantly (p < 0.00) more suicides resulting from barbiturate overdose compared to 2007-2012. Individuals using barbiturate overdose to die by suicide were significantly (p < 0.00) older than those using other medication and drugs (65 years compared to 55 years respectively). 48% of these cases were male. In barbiturate suicides, information sources (books or information on the internet, p < 0.01) and the presence of family during suicide (p < 0.00) occurred significantly more often than in suicides resulting from other medication and/or drugs overdose. The odds for barbiturate suicides were 4.8 higher (CI 2.6-9.2) after 2013 compared to before 2013 after correction for age, sex, city and postmortem toxicology results. DISCUSSION: Our data showed a rise in suicides resulting from barbiturate overdose whereas the total number of inhabitants and suicides resulting from medication overdose has remained more or less constant. Easy access of information or medication through the internet and 'right-to-die-organisations' may have directly impacted the rise in suicides resulting from an overdose of barbiturates. To our knowledge this is the first study analysing the rise of barbiturate suicides and the influence of media in published literature.


Assuntos
Barbitúricos/intoxicação , Overdose de Drogas/mortalidade , Suicídio/tendências , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Meios de Comunicação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Países Baixos/epidemiologia , Estudos Retrospectivos , Direito a Morrer
7.
Hum Reprod ; 24(11): 2788-95, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19648588

RESUMO

BACKGROUND: Little is known about post-natal growth in IVF offspring and the effects of rates of early post-natal growth on blood pressure and body fat composition during childhood and adolescence. METHODS: The follow-up study comprised 233 IVF children aged 8-18 years and 233 spontaneously conceived controls born to subfertile parents. Growth data from birth to 4 years of age, available for 392 children (n = 193 IVF, n = 199 control), were used to study early post-natal growth. Furthermore, early post-natal growth velocity (weight gain) was related to blood pressure and skinfold measurements at follow-up. RESULTS: We found significantly lower weight, height and BMI standard deviation scores (SDSs) at 3 months, and weight SDS at 6 months of age in IVF children compared with controls. Likewise, IVF children demonstrated a greater gain in weight SDS (P < 0.001), height SDS (P = 0.013) and BMI SDS (P = 0.029) during late infancy (3 months to 1 year) versus controls. Weight gain during early childhood (1-3 years) was related to blood pressure in IVF children (P = 0.014 systolic, 0.04 diastolic) but not in controls. Growth during late infancy was not related to skinfold thickness in IVF children, unlike controls (P = 0.002 peripheral sum, 0.003 total sum). Growth during early childhood was related to skinfold thickness in both IVF and controls (P = 0.005 and 0.01 peripheral sum and P = 0.003 and 0.005 total sum, respectively). CONCLUSIONS: Late infancy growth velocity of IVF children was significantly higher compared with controls. Nevertheless, early childhood growth instead of infancy growth seemed to predict cardiovascular risk factors in IVF children. Further research is needed to confirm these findings and to follow-up growth and development of IVF children into adulthood.


Assuntos
Pressão Sanguínea , Distribuição da Gordura Corporal , Fertilização in vitro , Adolescente , Estatura , Índice de Massa Corporal , Peso Corporal , Criança , Desenvolvimento Infantil , Pré-Escolar , Seguimentos , Humanos , Lactente , Recém-Nascido
8.
Ned Tijdschr Geneeskd ; 1632019 10 24.
Artigo em Holandês | MEDLINE | ID: mdl-31682092

RESUMO

OBJECTIVE: We investigated the degree of reporting of child deaths in 2017 and compared this with data from 2012. Furthermore, we assessed the characteristics of these deaths and in how many cases the forensic doctor performed a post-mortem examination. DESIGN: Observational research. METHOD: We requested data from 25 public health services (GGDs in Dutch) and the private organization Forensisch Artsen Rotterdam-Rijnmond (FARR) concerning child deaths that occurred in 2017. We distinguished between stillbirths, live births with death occurring ≤28 days post-partum and live births with death occurring > 28 days post-partum. Using mortality figures for 2017 obtained from Statistics Netherlands (CBS), the percentage of child death cases where discussions took place between the treating physician and a forensic doctor was determined both at regional and national level. RESULTS: In 2017, a total of 928 out of 1303 child death cases known to CBS was reported to the regional forensic doctor; this means a reporting rate of over 70%. For stillbirths the national reporting rate was 46.0% (200/435), for live births who died ≤ 28 days post-partum 84.0% (300/357) and for live births where death occurred > 28 days post-partum 83.8% (428/511). The reporting rate differed per province, Zuid-Holland having the highest reporting rate (93.1%) and Gelderland the lowest (74.1%). The reporting rate increased compared to 2012 in relation to stillbirths as well as live births. The forensic doctor was most likely to perform a post-mortem examination in cases where the death occurred outside the hospital and where it involved the death of minors older than 28 days. CONCLUSION: Treating physicians are increasingly fulfilling their legal obligation to report deceased minors to a forensic doctor, but the reporting rate is still not 100%. We therefore advise continued investment in order to improve the reporting rate, especially in regions where figures lag behind the national average.


Assuntos
Mortalidade Infantil , Natimorto/epidemiologia , Médicos Legistas , Humanos , Lactente , Nascido Vivo/epidemiologia , Países Baixos/epidemiologia
9.
J Interpers Violence ; 34(9): 1961-1977, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-27402581

RESUMO

Although the physical and psychological consequences of sexual violence can be severe, many victims do not report the violence to the police force. The current study examined the characteristics and the post-decisional attitude of the non-reporting sexual violence victims. In total, 287 victims of sexual violence completed an anonymous online questionnaire that assessed characteristics of the violence, whether or not the crime was reported, reasons for not reporting, and aspects that would have convinced non-reporters to report in retrospect. Eighty percent of the victims did not report the most recent sexual violence incident to the police ( n = 229). Nevertheless, 65% of the non-reporting victims ( n = 148) in retrospect would have reported to the police ("potential reporters"). Specific reasons for non-reporting and incident characteristics appear to relate to the post-decision attitude of non-reporting victims of sexual violence. "Lack of evidence" and "feelings of shame, guilt, and other emotions" appear to be more frequently mentioned by potential reporters as reasons for their decision to not report as compared with the definitive non-reporters. Likewise, being raped or sexually assaulted is predictive of potential reporting. Our findings are useful for policy makers to develop strategies to increase reporting rates of sexual violence victims.


Assuntos
Atitude , Vítimas de Crime/psicologia , Tomada de Decisões , Delitos Sexuais/psicologia , Adolescente , Adulto , Vítimas de Crime/estatística & dados numéricos , Feminino , Culpa , Humanos , Masculino , Pessoa de Meia-Idade , Países Baixos , Polícia , Delitos Sexuais/estatística & dados numéricos , Vergonha , Inquéritos e Questionários , Adulto Jovem
10.
J Clin Endocrinol Metab ; 93(5): 1682-8, 2008 May.
Artigo em Inglês | MEDLINE | ID: mdl-18285409

RESUMO

CONTEXT: Increasing evidence suggests that adverse conditions during early prenatal life are associated with cardiometabolic dysfunction in postnatal life. In vitro fertilization (IVF) conception may be an early prenatal life event with long-term health consequences. OBJECTIVE: Our objective was to investigate several cardiometabolic measures in 8- to 18-yr-old IVF singletons and spontaneously conceived controls born from subfertile parents. DESIGN AND SETTING: This follow-up study was conducted at the VU University Medical Center, Amsterdam, The Netherlands. PARTICIPANTS: Blood pressure was examined in 225 IVF-conceived children and 225 age- and gender-matched spontaneously conceived control children. Several indicators of insulin resistance were studied in a pubertal subpopulation (131 IVF children and 131 controls). MAIN OUTCOME MEASURES: Blood pressure, fasting glucose, and fasting insulin were determined. RESULTS: Systolic and diastolic blood pressure levels were higher in IVF children than controls (109 +/- 11 vs. 105 +/- 10 mm Hg, P < 0.001; and 61 +/- 7 vs. 59 +/- 7 mm Hg, P < 0.001, respectively). Children born after IVF were also more likely to be in the highest systolic and diastolic blood pressure quartiles (odds ratio = 2.1, 95% confidence interval 1.4, 3.3; odds ratio = 1.9, 95% confidence interval 1.2, 3.0, respectively). Furthermore, higher fasting glucose levels were observed in pubertal IVF children (5.0 +/- 0.4 vs. 4.8 +/- 0.4 mmol/liter in controls; P = 0.005). Blood pressure and fasting glucose differences could not be explained by current body size, birth weight, and other early life factors or by parental characteristics, including subfertility cause. CONCLUSIONS: These findings highlight the importance of continued cardiometabolic monitoring of IVF-conceived children and might contribute to current knowledge about periconceptional influences and their consequences in later life.


Assuntos
Glicemia/análise , Pressão Sanguínea , Fertilização in vitro , Resistência à Insulina , Adolescente , Criança , Jejum/sangue , Feminino , Seguimentos , Humanos , Insulina/sangue , Masculino
11.
Hum Reprod ; 23(12): 2791-8, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18689849

RESUMO

BACKGROUND: Previous studies demonstrated a link between adverse conditions during prenatal life and the development of diseases in adult life. It is still unclear whether IVF conception could permanently affect early prenatal development in humans, with post-natal health consequences. The objective of the present study is to examine pubertal development in 8-18-year-old IVF singletons and controls born from subfertile parents who attended one Dutch fertility clinic were included. METHODS: IVF singletons and controls born from subfertile parents who attended one clinic in the Dutch OMEGA study were included. Pubertal stage by Tanner's classification, age at menarche and menstrual cycle characteristics were studied in the total population (n = 233: 115 IVF-conceived boys and 118 IVF-conceived girls, each with age-matched comparison groups). Bone age and sex hormone levels were examined in two distinct pubertal subpopulations. RESULTS: Pubertal stage and age at menarche were not significantly different between IVF and control children. In the pubertal subpopulation, a higher bone age-chronological age (BA-CA) ratio and a larger BA-CA difference were observed in IVF-conceived girls compared with controls (1.04 +/- 0.07 versus 1.02 +/- 0.08, P = 0.022; 0.54 +/- 0.82 versus 0.18 +/- 1.00 year, P = 0.021, respectively). Furthermore, dehydroepiandrosterone sulphate (DHEAS) and LH levels were significantly higher in IVF-conceived girls than in control subjects (2.5 versus 1.9 micromol/l, P = 0.017, and 1.5 versus 0.6 U/l, P = 0.031, respectively). CONCLUSIONS: Bone age appeared to be advanced in pubertal IVF-conceived girls, but not in boys, compared with controls. Increased DHEAS and LH concentrations were found among IVF girls.


Assuntos
Fertilização in vitro , Fertilização , Puberdade/fisiologia , Adolescente , Desenvolvimento Ósseo/fisiologia , Criança , Estudos de Coortes , Sulfato de Desidroepiandrosterona/sangue , Feminino , Humanos , Hormônio Luteinizante/sangue , Masculino , Menarca/fisiologia , Estudos Retrospectivos , Fatores Sexuais
12.
Eur J Pediatr ; 167(11): 1289-95, 2008 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18270734

RESUMO

The aim of this study was to examine the school functioning of 8- to 18-year-old children born after in vitro fertilization (IVF). We compared 233 children born after IVF to 233 matched control children born spontaneously from parents with fertility problems on measures of education level, general cognitive ability, school performance (need for extra help, repeating a grade, special education), and rates of learning and developmental disorders. No differences were found between IVF and control children on these measures of school functioning. More than 60% of adolescents at secondary school attended high academic levels (with access to high school or university). We conclude that children and adolescents born after IVF show good academic achievement and general cognitive ability. They do not experience any more educational limitations than the naturally conceived children and adolescents of the control group. The tendency of reassuring school functioning already found in younger IVF children has been shown to continue at secondary school age.


Assuntos
Logro , Cognição , Deficiências do Desenvolvimento/epidemiologia , Fertilização in vitro/estatística & dados numéricos , Deficiências da Aprendizagem/epidemiologia , Adolescente , Criança , Feminino , Humanos , Masculino , Gravidez , Prevalência
13.
J Clin Endocrinol Metab ; 92(9): 3417-23, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17595253

RESUMO

CONTEXT: Increasing evidence suggests that adverse conditions during prenatal life are associated with the development of chronic diseases in adult life. It is still unclear whether in vitro fertilization (IVF) conception could affect the vulnerable developmental processes in humans occurring during early prenatal development with long-term perturbations of developmental pathways. OBJECTIVE: Our objective was to examine body composition in 8- to 18-yr-old IVF singletons and spontaneously conceived controls born from subfertile parents. DESIGN AND SETTING: This follow-up study was conducted at the VU University Medical Center in Amsterdam, The Netherlands. PARTICIPANTS: Participants included 233 IVF children (139 pubertal children) and 233 age- and gender-matched control children (143 pubertal children). MAIN OUTCOME MEASURES: Body composition measures were assessed by anthropometry and dual-energy x-ray absorptiometry in the pubertal subpopulation. RESULTS: IVF children had a significantly lower subscapular-triceps skinfold ratio and a significantly higher sum of peripheral skinfolds, peripheral body mass, and percentage of peripheral body fat as compared with controls. Although not reaching statistical significance, both dual-energy x-ray absorptiometry and skinfold measurements suggested that total body fat in IVF children is increased. Neither current and early risk factors nor parental factors, such as subfertility cause, could explain the differences in peripheral fat assessed by anthropometry between IVF children and controls. No differences in bone mineral composition between IVF children and controls were found. CONCLUSIONS: Our observations indicate that body fat composition in IVF children is disturbed. Follow-up of IVF children to monitor body fat pattern and potentially related health problems from adolescence into adulthood is of great importance.


Assuntos
Composição Corporal , Fertilização in vitro , Fertilização/fisiologia , Adolescente , Algoritmos , Estudos de Casos e Controles , Criança , Feminino , Seguimentos , Humanos , Masculino , Estudos Retrospectivos
14.
J Forensic Leg Med ; 43: 61-69, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27472480

RESUMO

The aim of the study was to assess interdoctorvariation and validity in death certification by forensic physicians using 19 written scenarios. The scenarios described typical cases from forensic-medical practice. Physicians were asked to determine the manner of death (natural/unnatural) and to provide an ICD-10 code for the cause of death. In contrast to most studies on this topic, the measure of agreement among physicians was chance-corrected and a standard was used to assess the correctness of the assigned cause and manner of death. Forty-seven physicians participated in the survey. The study demonstrated that forensic physicians varied widely in their conclusions. With respect to manner of death, adequate agreement (defined as kappa>0.70) was achieved in six scenarios (32% of all scenarios). Concerning the underlying cause of death, adequate agreement was reached in three cases (16% of all scenarios). Furthermore, predictors for the correctness of manner and cause of death were studied using logistic regression. Years of experience as a forensic physician significantly predicted the correctness of cause of death (p < 0.05). Other predictors remained insignificant. With regard to manner of death, none of the studied predictors proved to be significant. To conclude, there appears to be a lack of consistency among forensic physicians regarding death certification. The ICD-10 coding of causes of death applied by forensic physicians is questionable. Less experienced physicians need supervision by more experienced colleagues when making judgments concerning the cause of death. Altogether, there is an urgent need to work out consensus-based guidelines for forensic physicians on how to certify deaths.


Assuntos
Atestado de Óbito , Medicina Legal/normas , Adulto , Causas de Morte , Feminino , Humanos , Classificação Internacional de Doenças , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Países Baixos , Variações Dependentes do Observador , Competência Profissional , Inquéritos e Questionários
15.
J Forensic Leg Med ; 34: 62-6, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26165661

RESUMO

PURPOSE: The goal of this study was to ascertain accordance between cause of death established by the forensic physician and autopsy results in young sudden death victims in the Netherlands. METHODS: Sudden death victims aged 1-45 years examined by forensic physicians operating in the participating regions which also underwent an autopsy between January 2006 and December 2011 were included (n = 70). Cause of death established by the forensic physician based on the external medicolegal examination was compared with autopsy findings using the ICD10-classification. RESULTS: Autopsy findings revealed that the majority of sudden death victims have died from a cardiac disease (n = 51, 73%). Most of the presumed heart disease related cases were confirmed by autopsy (n = 13, 87%). On the contrary, a large number of deaths caused by circulatory diseases were not recognised by the forensic physician (n = 38, 75%). In most of these cases, the forensic physician was forced to report an undetermined cause due to the lack of a solid explanation for death. Cause of death reported by the forensic physician appeared to be in agreement with the autopsy results in 12 cases (17%). CONCLUSIONS: Cause of death determination in young sudden death victims is a difficult task for forensic physicians due to the limited tools available during the medicolegal examination. An effort should be made to standardize extensive post-mortem investigation after sudden death in the young. Autopsy can provide valuable information regarding the cause of death, which is of great importance in view of the identification of inheritable diseases among decedents and their families.


Assuntos
Causas de Morte , Morte Súbita/etiologia , Erros de Diagnóstico , Medicina Legal , Adolescente , Adulto , Criança , Pré-Escolar , Morte Súbita/patologia , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Países Baixos , Valor Preditivo dos Testes , Adulto Jovem
16.
Environ Mol Mutagen ; 40(2): 79-84, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-12203399

RESUMO

Bleomycin-induced chromosomal instability, generally referred to as mutagen sensitivity, is associated with an increased risk for the development of environmentally related cancer including head and neck squamous cell carcinoma and lung cancer. On average, the cultured lymphocytes of patients with these types of cancer show an increased number of chromatid breaks per cell after bleomycin exposure in the late S or G2 phase of the cell cycle as compared to lymphocytes from control persons. The aim of the present study was to investigate whether cell cycle regulation is involved in mutagen sensitivity. We determined cell cycle arrest after bleomycin-induced DNA damage in 21 lymphoblastoid cell lines that varied in mutagen sensitivity score. An ataxia telangiectasia (AT) cell line was included for comparison. Using a cut-off point of 0.70 breaks per cell, eight cell lines were classified as insensitive and 13 cell lines showed the hypersensitive phenotype. Compared to insensitive cell lines, bleomycin-treated hypersensitive cells remained at a relatively high level of DNA synthesis, as measured by thymidine incorporation, and showed a decreased accumulation of cells in G2 and M phase, as measured by flow cytometry. AT cells showed an extremely high mutagen sensitivity score, a high level of DNA synthesis, and a strong G2 block. In conclusion, mutagen sensitivity is associated with "damage-resistant growth," which is indicative of impaired cell cycle arrest. By which specific pathway(s) this checkpoint defect is explained has yet to be elucidated; however, it is probably distinct from the checkpoint defect in AT cells. Environ. Mol. Mutagen. 40:79-84, 2002.


Assuntos
Bleomicina/toxicidade , Ciclo Celular/fisiologia , Aberrações Cromossômicas , Dano ao DNA , Linfócitos/patologia , Mutagênicos/toxicidade , Ciclo Celular/efeitos dos fármacos , Divisão Celular/efeitos dos fármacos , Cromátides/efeitos dos fármacos , Citometria de Fluxo , Fase G2/efeitos dos fármacos , Humanos , Linfócitos/citologia , Linfócitos/efeitos dos fármacos , Mitose/efeitos dos fármacos , Valores de Referência , Timidina/metabolismo , Células Tumorais Cultivadas
18.
J Forensic Leg Med ; 25: 55-9, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24931863

RESUMO

The Forensic Medical Service of the Public Health Service offers health care to detainees in police cells in Amsterdam. This study describes the registered mental health, addiction and social problems and compares them to the self-reported problems among a sample of detainees. Registers of the Forensic Medical Service are related to information from registers of police detention episodes. A general assessment of substance use, mental health and social problems is obtained by interviewing a sample of 264 detainees. The Forensic Medical Service was contacted in 24% of the 17,321 detention episodes. In 14% of the episodes mental or substance related disorders were observed. Within the sample 59% scored positively on indicators of substance abuse or mental health problems, 35% had additional social problems (debts, unemployment, housing). This proportion increased with age. It is concluded that substance abuse and mental health problems combined with social problems are highly prevalent among detainees, especially among the older ones. This urges for a close cooperation between Public Mental Health Care and Forensic Medical Services.


Assuntos
Transtornos Mentais/epidemiologia , Prisioneiros/estatística & dados numéricos , Adulto , Fatores Etários , Feminino , Pessoas Mal Alojadas/estatística & dados numéricos , Humanos , Entrevistas como Assunto , Masculino , Pessoa de Meia-Idade , Países Baixos/epidemiologia , Polícia , Problemas Sociais , Desemprego/estatística & dados numéricos , Adulto Jovem
19.
J Forensic Leg Med ; 26: 24-8, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25066169

RESUMO

BACKGROUND: In many countries, forensic physicians function as primary care providers for detainees in police custody. Their task is comparable to the tasks of general practitioners. Nevertheless, problems presented by both patient populations may differ. We therefore aimed to systematically compare presented problems and medication use in a population of police detainees to those of regular patients in general practice. METHODS: Health problems and prescription medications of 3232 detainees seen by the Amsterdam Forensic Medical Service were compared to those of general practice patients (n = 78,975) adjusted for age and gender during a 12-month period. RESULTS: Among those obtaining medical attention (28% of all detainees), almost 50% were diagnosed with mental health problems, with substance abuse as the leading reason for consultation. Forty-two percent received at least one prescription affecting the nervous system. In general practice, 17% (P < 0.001) of patients consulting their GP were diagnosed with mental health problems and 22% (P < 0.001) were prescribed medications affecting the nervous system. CONCLUSION: The magnitude of mental health problems among police detainees has significant implications for the qualifications of police health staff and those who provide health care in the police setting especially concerning substance abuse.


Assuntos
Fármacos do Sistema Nervoso Central/uso terapêutico , Prescrições de Medicamentos/estatística & dados numéricos , Transtornos Mentais/epidemiologia , Prisioneiros/estatística & dados numéricos , Encaminhamento e Consulta/estatística & dados numéricos , Adulto , Feminino , Medicina Geral , Humanos , Masculino , Transtornos Mentais/diagnóstico , Países Baixos/epidemiologia , Polícia , Atenção Primária à Saúde
20.
Psychiatr Serv ; 64(10): 1047-50, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24081404

RESUMO

OBJECTIVE: Research on the mental health of police detainees is scarce. This study aimed to identify the proportion of persons detained by the Police Service Amsterdam-Amstelland who screened positive for a serious mental condition. METHODS: A survey conducted in 2009 among 264 randomly selected detainees assessed demographic characteristics and general medical and mental health and included use of the Brief Jail Mental Health Screen (BJMHS) (N=248). RESULTS: Almost 40% of survey respondents screened positive on the BJMHS, indicating a need for further evaluation. This rate was lower than the rate reported for police detainees in Australia but substantially higher than the rates reported for persons incarcerated in U.S. jails. CONCLUSIONS: More systematic research is needed to examine reasons for reports of different rates of mental illness among detainees in different countries.


Assuntos
Crime/psicologia , Transtornos Mentais/diagnóstico , Adulto , Crime/estatística & dados numéricos , Feminino , Humanos , Entrevista Psicológica , Masculino , Transtornos Mentais/epidemiologia , Países Baixos/epidemiologia , Polícia , Escalas de Graduação Psiquiátrica
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