Detalhe da pesquisa
1.
A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone.
FASEB J;
34(6): 7234-7246, 2020 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32347987
2.
Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress.
FASEB J;
34(2): 2087-2104, 2020 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31907991
3.
The neuroprotective effect of Klotho is mediated via regulation of members of the redox system.
J Biol Chem;
289(35): 24700-15, 2014 Aug 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25037225
4.
The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.
J Neurosci;
33(5): 1927-39, 2013 Jan 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23365232
5.
Identification of cleavage sites leading to the shed form of the anti-aging protein klotho.
Biochemistry;
53(34): 5579-87, 2014 Sep 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25110992
6.
Klotho, PTSD, and advanced epigenetic age in cortical tissue.
Neuropsychopharmacology;
46(4): 721-730, 2021 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33096543
7.
Cell-type dependent modulation of Notch signaling by the amyloid precursor protein.
J Neurochem;
113(1): 262-74, 2010 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20089128
8.
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17.
Proc Natl Acad Sci U S A;
104(50): 19796-801, 2007 Dec 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18056631
9.
Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho.
PLoS One;
15(1): e0226382, 2020.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31929539
10.
Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling.
J Alzheimers Dis;
67(3): 1089-1106, 2019.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30776010
11.
Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS.
J Mol Neurosci;
69(2): 264-285, 2019 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31250273
12.
Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex.
J Mol Neurosci;
64(2): 175-184, 2018 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29352444
13.
The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination.
J Mol Neurosci;
57(2): 185-96, 2015 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26067431
14.
The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line.
J Mol Neurosci;
55(1): 76-90, 2015 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24907942
15.
Stability of RNA from the retina and retinal pigment epithelium in a porcine model simulating human eye bank conditions.
Invest Ophthalmol Vis Sci;
44(6): 2730-5, 2003 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12766080
16.
Identification and localization of major soluble vitreous proteins in human ocular tissue.
Am J Ophthalmol;
137(4): 655-61, 2004 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15059704
17.
Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants.
Am J Neurodegener Dis;
2(1): 15-28, 2013.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23515184
18.
Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-ß precursor protein dimerization.
Am J Neurodegener Dis;
1(1): 75-87, 2012.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22822474
19.
Detection of amyloid-ß protein precursor homo-interactions using beta-galactosidase enzyme fragment complementation.
J Alzheimers Dis;
26(4): 647-55, 2011.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21694460
20.
Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts.
Glia;
56(1): 118-33, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17963267