RESUMO
Twinning is an important deformation mode of face-centered-cubic (FCC) medium- and high-entropy alloys, especially under extreme loading conditions. However, the twinning mechanism in these alloys that have a low or even negative stacking fault energy remains debated. Here, we report atomic-scale in situ observations of the deformation process of a prototypical CrCoNi medium-entropy alloy under tension. We found that the parent FCC phase first transforms into a hexagonal close-packed (HCP) phase through Shockley partial dislocations slipping on the alternate {111} planes. Subsequently, the HCP phase rapidly changes to an FCC twin band. Such reversible phase transformation assisted twinning is greatly promoted by external tensile loads, as elucidated by geometric phase analysis. These results indicate the previously underestimated role of the metastable HCP phase in nanotwin nucleation and early plastic deformations of CrCoNi alloys and shed light on microstructure regulation of medium-entropy alloys with enhanced mechanical properties.
RESUMO
Background: Although the association between neurodegenerative diseases, such as dementia, and traumatic brain injury (TBI) has long been known, the association between dementia and TBI with epilepsy has been controversial. Aim: This data-driven population-based study is designed to investigate the association between dementia and epilepsy after TBI within a 2-year period. Methods: This case-control cohort study was conducted using the Longitudinal Health Insurance Database 2000 (LHID2000). We included 784 individuals ambulatory or hospitalized for TBI with epilepsy from 2001 to 2011, compared with 2992 patients with TBI without epilepsy who were matched for characteristics including sex, age, and healthcare resource use index date. Every participant was followed up for 5 years to ascertain any dementia development. Data were stratified and analyzed using the Cox proportional hazards regression. Results: Through the 5-year follow-up period, 39 patients (5.21%) with TBI with epilepsy and 55 (1.53%) with TBI without epilepsy developed dementia. TBI with epilepsy was independently associated with a >3.03 times risk of dementia after correcting for age, sex, and comorbidities. Conclusion: These findings suggest an increased risk of dementia in patients with TBI with epilepsy. Our research recommends that individuals with TBI and epilepsy be monitored more intensively.
RESUMO
Surface atom diffusion is a ubiquitous phenomenon in nanostructured metals with ultrahigh surface-to-volume ratios. However, the fundamental atomic mechanism of surface atom diffusion remains elusive. Here, we report in situ atomic-scale observations of surface pressure-driven atom diffusion in gold nanocrystals at room temperature using high-resolution transmission electron microscopy with a high-speed detection camera. The topmost layer of atoms on (001) plane initially diffuse in a column-by-column manner. As diffusion proceeds, the remaining atomic columns collectively inject into adjacent underlayer, accompanied by nucleation of a surface dislocation. In comparison, atoms on (111) plane directly diffuse to the base without collective injection. Quantitative calculations indicate that these crystal plane orientation-dependent atom diffusion behaviors contribute to the larger diffusion coefficient of (111) plane compared to (001) plane in addition to the effect of diffusion activation energy. Our findings provide valuable insights into atomic mechanisms of diffusion-dominant morphology evolution of nanostructured metals and guide the design of nanostructured materials with enhanced structural stability.