Detalhe da pesquisa
1.
The intrinsic substrate specificity of the human tyrosine kinome.
Nature;
629(8014): 1174-1181, 2024 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38720073
2.
Sudden Unexpected Death in Epilepsy: Pathogenesis, Risk Factors, and Prevention.
Semin Neurol;
42(5): 658-664, 2022 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36223819
3.
Neurological manifestations as primary presentation of COVID-19 in hospitalized patients.
Acta Neurol Scand;
143(5): 569-574, 2021 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33559885
4.
A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity.
J Biol Chem;
293(25): 9604-9613, 2018 06 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29739849
5.
Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure.
Circulation;
133(21): 2038-49, 2016 May 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27059949
6.
Pathogenic mechanisms underlying X-linked Charcot-Marie-Tooth neuropathy (CMTX6) in patients with a pyruvate dehydrogenase kinase 3 mutation.
Neurobiol Dis;
94: 237-44, 2016 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27388934
7.
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.
Proc Natl Acad Sci U S A;
110(24): 9728-33, 2013 Jun 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23716694
8.
Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells.
J Biol Chem;
289(9): 6212-24, 2014 Feb 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24415759
9.
Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket.
J Biol Chem;
289(7): 4432-43, 2014 Feb 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24356970
10.
Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase.
J Biol Chem;
289(30): 20583-93, 2014 Jul 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24895126
11.
A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.
Hum Mol Genet;
22(7): 1404-16, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23297365
12.
Zinc-dependent interaction between JAB1 and pre-S2 mutant large surface antigen of hepatitis B virus and its implications for viral hepatocarcinogenesis.
J Virol;
87(23): 12675-84, 2013 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24049181
13.
Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase.
J Biol Chem;
287(12): 9178-92, 2012 Mar 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22291014
14.
Phenylbutyrate therapy for maple syrup urine disease.
Hum Mol Genet;
20(4): 631-40, 2011 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21098507
15.
Structural and thermodynamic basis for weak interactions between dihydrolipoamide dehydrogenase and subunit-binding domain of the branched-chain alpha-ketoacid dehydrogenase complex.
J Biol Chem;
286(26): 23476-88, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21543315
16.
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis.
Nat Metab;
4(12): 1775-1791, 2022 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36443523
17.
Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm).
J Biol Chem;
285(1): 265-76, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19858196
18.
Prognostic Significance of Cyclic Seizures in Status Epilepticus.
J Clin Neurophysiol;
38(6): 516-524, 2021 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32398513
19.
Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate.
J Biol Chem;
284(49): 34458-67, 2009 Dec 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19833728
20.
Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.
Anal Biochem;
407(1): 89-103, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20667444