Detalhe da pesquisa
1.
A clickable melphalan for monitoring DNA interstrand crosslink accumulation and detecting ICL repair defects in Fanconi anemia patient cells.
Nucleic Acids Res;
51(15): 7988-8004, 2023 08 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37395445
2.
Triangular Regulation of Cucurbit[8]uril 1:1 Complexes.
J Am Chem Soc;
141(14): 5897-5907, 2019 04 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30808163
3.
Conditional generation of free radicals by selective activation of alkoxyamines: towards more effective and less toxic targeting of brain tumors.
Chem Sci;
14(29): 7988-7998, 2023 Jul 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37502321
4.
From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia.
Nat Commun;
14(1): 3079, 2023 05 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37248212
5.
Synthesis and biological evaluation of novel anticancer bivalent colchicine-tubulizine hybrids.
Bioorg Med Chem;
20(14): 4271-8, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22739088
6.
CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation.
J Med Chem;
65(7): 5660-5674, 2022 04 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35348328
7.
Allocolchicinoids bearing a Michael acceptor fragment for possible irreversible binding of tubulin.
RSC Med Chem;
11(6): 696-706, 2020 Jun 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33479669
8.
Discovery of dihydrofuranoallocolchicinoids - Highly potent antimitotic agents with low acute toxicity.
Eur J Med Chem;
207: 112724, 2020 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32827941
9.
4-arylcoumarin analogues of combretastatins stimulate apoptosis of leukemic cells from chronic lymphocytic leukemia patients.
Exp Hematol;
36(12): 1625-33, 2008 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18922614
10.
Synthesis and biological evaluation of polymethoxylated 4-heteroarylcoumarins as tubulin assembly inhibitor.
Bioorg Med Chem;
16(19): 8806-12, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18805012
11.
Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.
J Med Chem;
61(13): 5719-5732, 2018 07 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29883107
12.
Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.
Nat Commun;
8(1): 1420, 2017 11 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29127277
13.
Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.
J Med Chem;
59(4): 1634-41, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26735842
14.
Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery.
ACS Chem Biol;
11(8): 2140-8, 2016 08 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27219844
15.
Synthesis and biological evaluation of furanoallocolchicinoids.
J Med Chem;
58(2): 692-704, 2015 Jan 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25496412
16.
Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins.
J Med Chem;
46(25): 5437-44, 2003 Dec 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14640552
17.
2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.
J R Soc Interface;
11(90): 20130860, 2014 Jan 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24196694
18.
New Ianthelliformisamine derivatives as antibiotic enhancers against resistant Gram-negative bacteria.
J Med Chem;
57(10): 4263-72, 2014 May 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24801877
19.
The indolylcoumarin COUFIN exhibits potent activity against renal carcinoma cells without affecting hematopoietic system.
Anticancer Agents Med Chem;
14(6): 862-71, 2014.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24568163
20.
Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer.
PLoS One;
7(9): e43409, 2012.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23028451