Detalhe da pesquisa
1.
Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.
Cell;
160(6): 1196-208, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25728669
2.
Modulation of human thrombopoietin receptor conformations uncouples JAK2 V617F-driven activation from cytokine-induced stimulation.
Blood;
142(21): 1818-1830, 2023 11 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37616564
3.
Therapeutic activity of GARP:TGF-ß1 blockade in murine primary myelofibrosis.
Blood;
141(5): 490-502, 2023 02 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36322928
4.
Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms.
Blood;
141(8): 917-929, 2023 02 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36356299
5.
Novel germline JAK2R715T mutation causing PV-like erythrocytosis in 3 generations. Amelioration by Ropeg-Interferon.
Am J Hematol;
2024 Apr 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38629639
6.
CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag.
Blood;
138(6): 480-485, 2021 08 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34010413
7.
Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor.
Blood;
137(14): 1920-1931, 2021 04 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33202418
8.
Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms.
Blood;
138(22): 2231-2243, 2021 12 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34407546
9.
MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491.
Blood;
135(12): 948-953, 2020 03 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31978223
10.
Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants.
Blood;
133(25): 2669-2681, 2019 06 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30902807
11.
JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera.
Blood;
134(26): 2388-2398, 2019 12 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31697804
12.
Advances in covalent kinase inhibitors.
Chem Soc Rev;
49(9): 2617-2687, 2020 May 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32227030
13.
Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide.
J Biol Chem;
294(15): 5854-5866, 2019 04 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30755484
14.
Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL.
Blood;
131(4): 421-425, 2018 01 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29187379
15.
A biological profile for diagnosis and outcome of COVID-19 patients.
Clin Chem Lab Med;
58(12): 2141-2150, 2020 10 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33064667
16.
Differential effect of inhibitory strategies of the V617 mutant of JAK2 on cytokine receptor signaling.
J Allergy Clin Immunol;
144(1): 224-235, 2019 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30707971
17.
The 2 faces of ERK2 in MPNs.
Blood;
140(4): 298-300, 2022 07 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35900786
18.
Degrading JAK2 in ALL by ruxolitinib-based PROTACs.
Blood;
138(23): 2301-2302, 2021 12 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34882211
19.
Cooperation of germ line JAK2 mutations E846D and R1063H in hereditary erythrocytosis with megakaryocytic atypia.
Blood;
128(10): 1418-23, 2016 09 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27389715
20.
Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.
Blood;
127(10): 1317-24, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26608331