Personality Related to Quality-of-Life Improvement After Deep Brain Stimulation in Parkinson's Disease (PSYCHO-STIM II).

BACKGROUND: Deep brain stimulation of the sub-thalamic nucleus (DBS-STN) reduces symptoms in Parkinson's disease (PD) patients with motor fluctuations. However, some patients may not feel ameliorated afterwards, despite an objective motor improvement. It is thus important to find new predictors of patients' quality of life (QoL) amelioration after DBS-STN. We hypothesized that personality dimensions might affect QoL after DBS-STN. OBJECTIVE: To evaluate associations between personality dimensions and QoL improvement one year after DBS-STN. METHODS: DBS-STN-PD patients (n = 303) having answered the "Temperament and Character Inventory" (TCI) before surgery and the PDQ-39 before and one year after surgery were included, from the cohort study PREDI-STIM. Linear regression models were used to evaluate associations between TCI dimensions and change in PDQ-39 scores after DBS-STN. RESULTS: Novelty Seeking and Cooperativeness scores before surgery were positively associated with PDQ-39 scores improvement after DBS-STN (FDR-adjusted p < 0.01). Moreover, paradoxically unimproved patients with deterioration of their PDQ-39 scores after DBS-STN despite improvement of their MDS-UPDRS-IV scores had lower Cooperativeness scores, while paradoxically improved patients with amelioration of their PDQ-39 scores despite deterioration of their MDS-UPDRS-IV scores had higher Reward Dependence scores. CONCLUSION: Some presurgical personality dimensions were significantly associated with QoL amelioration and discrepancy between motor state and QoL changes after DBS-STN in PD. Educational programs before DBS-STN should take in account patient personality dimensions to better deal with their expectations.

Détresse psychologique et sentiment de solitude : quels impacts du confinement lié à la Covid-19 dans la population française ?

The COVID-19 pandemic created a worldwide health crisis. This crisis resulted in an almost two-month lockdown in France - lockdown that has serious impacts on physical and mental health. This unprecedented situation resulted in an important reflection about the mental health of the persons experiencing this crisis. The aim of our study was to apprehend the emotional state of the persons experiencing this lockdown, taking into account day-to-day life and feelings of loneliness. In order to develop a good comprehension of the impact of this situation on mental health, we recruited 4689 persons through an online survey between March 17th and May 11th of 2020 in France. We used several psychometric tools that gave us access to various data, such as socio-biographical information, situational variables - place of living, work context, etc. - and psychological state - depressive symptoms, anxiety, loneliness, etc. This paper focuses mostly on the UCLA loneliness scale, and the French Canadian version of the Psychiatric Symptoms Index (PSI), which measures psychological distress, as well as depressive symptoms, anxiety and cognitive impairment. Results show a moderate psychological distress for 27.5% of our sample, with depressive symptomatology, irritability or cognitive impairment. There is also a high loneliness feeling in 21.8% of the sample. Psychological distress is explained by sociodemographic variables - such as gender and age - but also by situational information - type of housing and persistence of income - and the loneliness feeling. If this pandemic and this lockdown show a clear impact on the emotional life of the French population, these results need to be taken into account with a broader range of situational and psychological variables. These additional data would help us have a more thorough understanding of the underlying factors explaining this difficult experience of the crisis. This comprehension also needs to go further in time and think about the repercussions beyond the end of the lockdown, in order to observe the evolution of these emotions and the potential persistence of psychological distress.

Personality dimensions of patients can change during the course of parkinson's disease.

BACKGROUND: Studies assessing personality dimensions by the "Temperament and Character Inventory" (TCI) have previously found an association between Parkinson's disease (PD) and lower Novelty Seeking and higher Harm Avoidance scores. Here, we aimed to describe personality dimensions of PD patients with motor fluctuations and compare them to a normative population and other PD populations. METHODS: All PD patients awaiting Deep Brain Stimulation (DBS) answered the TCI before neurosurgery. Their results were compared to those of historical cohorts (a French normative population, a de novo PD population, and a PD population with motor fluctuations). RESULTS: Most personality dimensions of our 333 included PD patients with motor fluctuations who are candidates for DBS were different from those of the normative population and some were also different from those of the De Novo PD population, whereas they were similar to those of another population of PD patients with motor fluctuations. CONCLUSIONS: During the course of PD, personality dimensions can change in parallel with the development of motor fluctuations, either due to the evolution of the disease and/or dopaminergic treatments.