Detalhe da pesquisa
1.
Chemical modification patterns for microRNA therapeutic mimics: a structure-activity relationship (SAR) case-study on miR-200c.
Nucleic Acids Res;
52(6): 2792-2807, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38421619
2.
Unravelling the Link between Oligonucleotide Structure and Diastereomer Separation in Hydrophilic Interaction Chromatography.
Anal Chem;
96(24): 9994-10002, 2024 Jun 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38855895
3.
Ionic Liquid-Mediated Approach for the Synthesis of Site-Specific Thioether Conjugates.
Chemistry;
29(28): e202203915, 2023 May 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36929206
4.
Advances in the design of new types of inhaled medicines.
Prog Med Chem;
61: 93-162, 2022.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35753716
5.
Pyrimidin-6-yl Trifluoroborate Salts as Versatile Templates for Heterocycle Synthesis.
Angew Chem Int Ed Engl;
60(17): 9412-9415, 2021 04 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33570831
6.
Synthetic and Mechanistic Investigation of an Oxime Ether Electrocyclization Approach to Heteroaromatic Boronic Acid Derivatives.
Chemistry;
24(38): 9530-9534, 2018 Jul 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29750380
7.
Synthesis and Modular Reactivity of Pyrazole 5-Trifluoroborates: Intermediates for the Preparation of Fully Functionalized Pyrazoles.
J Org Chem;
82(3): 1688-1696, 2017 02 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28081596
8.
Modulation of Hexadecyl-LPA-Mediated Activation of Mast Cells and Microglia by a Chemical Probe for LPA5.
Chembiochem;
17(9): 861-5, 2016 05 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26812365
9.
An Alkyne Diboration/6π-Electrocyclization Strategy for the Synthesis of Pyridine Boronic Acid Derivatives.
Angew Chem Int Ed Engl;
55(19): 5834-6, 2016 05 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27059895
10.
Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.
J Biol Chem;
288(42): 30125-30138, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24003220
11.
Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta.
Biochem Biophys Res Commun;
449(3): 327-31, 2014 Jul 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24845568
12.
Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)phenyl] amide as histamine H(3) receptor antagonist for the treatment of depression.
Bioorg Med Chem Lett;
23(23): 6269-73, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24139584
13.
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I).
Bioorg Med Chem Lett;
23(11): 3416-20, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23591110
14.
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part II).
Bioorg Med Chem Lett;
23(11): 3421-6, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23591112
15.
Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep-wake disorders.
Bioorg Med Chem Lett;
23(22): 6141-5, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24076172
16.
Analyzing proteolytic stability and metabolic hotspots of therapeutic peptides in two rodent pulmonary fluids.
J Pharm Biomed Anal;
224: 115156, 2023 Feb 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36463768
17.
Strategies for predictive modeling of overloaded oligonucleotide elution profiles in ion-pair chromatography.
J Chromatogr A;
1711: 464446, 2023 Nov 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37865023
18.
Gymnotic uptake of AntimiRs alter microRNA-34a levels in 2D and 3D epithelial cell culture.
Mol Ther Nucleic Acids;
33: 898-907, 2023 Sep 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37680982
19.
Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids.
Nat Commun;
14(1): 7475, 2023 11 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37978172
20.
European Medicinal Chemistry Leaders in Industry (EMCL) - On the Status and Future of Medicinal Chemistry Research in Europe.
ChemMedChem;
18(13): e202300127, 2023 07 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37276375