Children and the Elderly: Wealth Inequality Among America's Dependents.

Life cycle theory predicts that elderly households have higher levels of wealth than households with children, but these wealth gaps are likely dynamic, responding to changes in labor market conditions, patterns of debt accumulation, and the overall economic context. Using Survey of Consumer Finances data from 1989 through 2013, we compare wealth levels between and within the two groups that make up America's dependents: the elderly and child households (households with a resident child aged 18 or younger). Over the observed period, the absolute wealth gap between elderly and child households in the United States increased substantially, and diverging trends in wealth accumulation exacerbated preexisting between-group disparities. Widening gaps were particularly pronounced among the least-wealthy elderly and child households. Differential demographic change in marital status and racial composition by subgroup do not explain the widening gap. We also find increasing wealth inequality within child households and the rise of a "parental 1 %." During a time of overall economic growth, the elderly have been able to maintain or increase their wealth, whereas many of the least-wealthy child households saw precipitous declines. Our findings suggest that many child households may lack sufficient assets to promote the successful flourishing of the next generation.

Midpregnancy Marriage and Divorce: Why the Death of Shotgun Marriage Has Been Greatly Exaggerated.

Conventional wisdom holds that births following the colloquially termed "shotgun marriage"-that is, births to parents who married between conception and the birth-are nearing obsolescence. To investigate trends in shotgun marriage, we matched North Carolina administrative data on nearly 800,000 first births among white and black mothers to marriage and divorce records. We found that among married births, midpregnancy-married births (our preferred term for shotgun-married births) have been relatively stable at about 10 % over the past quarter-century while increasing substantially for vulnerable population subgroups. In 2012, among black and white less-educated and younger women, midpregnancy-married births accounted for approximately 20 % to 25 % of married first births. The increasing representation of midpregnancy-married births among married births raises concerns about well-being among at-risk families because midpregnancy marriages may be quite fragile. Our analysis revealed, however, that midpregnancy marriages were more likely to dissolve only among more advantaged groups. Of those groups considered to be most at risk of divorce-namely, black women with lower levels of education and who were younger-midpregnancy marriages had the same or lower likelihood of divorce as preconception marriages. Our results suggest an overlooked resiliency in a type of marriage that has only increased in salience.

Ion-regulated allosteric binding of fullerenes (C60 and C70) by tetrathiafulvalene-calix[4]pyrroles.

The effect of ionic species on the binding of fullerenes (C60 and C70) by tetrathiafulvalene-calix[4]pyrrole (TTF-C4P) receptors and the nature of the resulting supramolecular complexes (TTF-C4P + fullerene + halide anion + tetraalkylammonium cation) was studied in the solid state through single crystal X-ray diffraction methods and in dichloromethane solution by means of continuous variation plots and UV-vis spectroscopic titrations. These analyses revealed a 1:1 stoichiometry between the anion-bound TTF-C4Ps and the complexed fullerenes. The latter guests are bound within the bowl-like cup of the C4P in a ball-and-socket binding mode. The interactions between the TTF-C4P receptors and the fullerene guests are highly influenced by both the nature of halide anions and their counter tetraalkylammonium cations. Three halides (F(-), Cl(-), and Br(-)) were studied. All three potentiate the binding of the two test fullerenes by inducing a conformational change from the 1,3-alternate to the cone conformer of the TTF-C4Ps, thus acting as positive heterotropic allosteric effectors. For a particular halide anion, the choice of tetraalkylammonium salts serves to modulate the strength of the TTF-C4P-fullerene host-guest binding interactions and, in conjunction with variations in the halide anion, can be exploited to alter the inherent selectivity of the host for a given fullerene. Differences in binding are reflected in the excited state optical properties. Overall, the present four-component system provides an illustration of how host-guest binding events involving appropriately designed artificial receptors can be fine-tuned via the addition of simple ionic species as allosteric modulators.

Effects of statewide job losses on adolescent suicide-related behaviors.

OBJECTIVES: We investigated the impact of statewide job loss on adolescent suicide-related behaviors. METHODS: We used 1997 to 2009 data from the Youth Risk Behavior Survey and the Bureau of Labor Statistics to estimate the effects of statewide job loss on adolescents' suicidal ideation, suicide attempts, and suicide plans. Probit regression models controlled for demographic characteristics, state of residence, and year; samples were divided according to gender and race/ethnicity. RESULTS: Statewide job losses during the year preceding the survey increased girls' probability of suicidal ideation and suicide plans and non-Hispanic Black adolescents' probability of suicidal ideation, suicide plans, and suicide attempts. Job losses among 1% of a state's working-age population increased the probability of girls and Blacks reporting suicide-related behaviors by 2 to 3 percentage points. Job losses did not affect the suicide-related behaviors of boys, non-Hispanic Whites, or Hispanics. The results were robust to the inclusion of other state economic characteristics. CONCLUSIONS: As are adults, adolescents are affected by economic downturns. Our findings show that statewide job loss increases adolescent girls' and non-Hispanic Blacks' suicide-related behaviors.

The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity.

Actinobacteria, the bacterial phylum most renowned for natural product discovery, has been established as a valuable source for drug discovery and biotechnology but is underrepresented within accessible genome and strain collections. Herein, we introduce the Natural Products Discovery Center (NPDC), featuring 122,449 strains assembled over eight decades, the genomes of the first 8490 NPDC strains (7142 Actinobacteria), and the online NPDC Portal making both strains and genomes publicly available. A comparative survey of RefSeq and NPDC Actinobacteria highlights the taxonomic and biosynthetic diversity within the NPDC collection, including three new genera, hundreds of new species, and ~7000 new gene cluster families. Selected examples demonstrate how the NPDC Portal's strain metadata, genomes, and biosynthetic gene clusters can be leveraged using genome mining approaches. Our findings underscore the ongoing significance of Actinobacteria in natural product discovery, and the NPDC serves as an unparalleled resource for both Actinobacteria strains and genomes.

Porphyrins fused with strongly electron-donating 1,3-dithiol-2-ylidene moieties: redox control by metal cation complexation and anion binding.

A new class of redox-active free base and metalloporphyrins fused with the 1,3-dithiol-2-ylidene subunits present in tetrathiafulvalene, termed MTTFP (M = H2, Cu, Ni, Zn), have been prepared and characterized. The strong electron-donating properties of MTTFP were probed by electrochemical measurement and demonstrated that oxidation potentials can be tuned by metalation of the free base form, H2TTFP. X-ray crystal structures of H2TTFP, ZnTTFP, and CuTTFP revealed that a severe saddle-shape distortion was observed with the dithiole rings bent out of the plane toward one another in the neutral form. In contrast, the structure of the two-electron oxidized species (CuTFFP(2+)) is planar, corresponding to a change from a nonaromatic to aromatic structure upon oxidation. A relatively large two-photon absorption (TPA) cross-section value of H2TTFP(2+) (1200 GM) was obtained for the free base compound, a value that is much higher than those typically seen for porphyrins (<100 GM). Augmented TPA values for the metal complexes were also seen. The strong electron-donating ability of ZnTTFP was further enhanced by binding of Cl(-) and Br(-) as revealed by thermal electron-transfer between ZnTTFP and Li(+)-encapsulated C60 (Li(+)@C60) in benzonitrile, which was "switched on" by the addition of either Cl(-) or Br(-) (as the tetrabutylammonium salts). The X-ray crystal structure of Cl(-)-bound ZnTTFP was determined and provided support for the strong binding between the Cl(-) anion and the Zn(2+) cation present in ZnTTFP.

A systematic review of the frequency of features of the seven-point checklist in proven cutaneous melanoma: The importance of change.

Background: Pigmented skin lesions in human adults can present with several different visible features that may indicate signs of malignancy, particularly melanoma. Patient and clinician awareness of these features can aid the early recognition and melanoma diagnosis improving patient outcomes. The seven-point checklist (7PCL) is a clinical prediction rule advocated by the National Institute for Health Care Excellence to aid the assessment of pigmented skin lesions in primary care to indicate referral for specialist opinion. Objectives: Assess the current evidence to establish which features of the 7PC present more frequently, so public education and clinician assessment can be focused to maximise early diagnosis and minimise referrals of benign lesions. Methods: A systematic review of published evidence identified studies that assessed the seven features of the 7PCL in histologically proven melanomas. Two independent reviewers screened eligible studies and independently extracted data and assessed quality. Results: 112 studies were screened, 20 were assessed in full, seven met the inclusion criteria. 1184 histologically diagnosed melanomas were assessed using the 7PCL. Four studies involved patients assessing 335 melanomas, and three involved clinicians who assessed 849 melanomas. The most common feature identified was a change in size of the lesion, and the least common was inflammation. Conclusions: The most frequently occurring features of melanoma involve shape, size and colour, however focussing on changes in features, rather than irregularity, is more likely to identify early melanoma and increase the accuracy of referrals.

The Buffering Effect of State Eviction and Foreclosure Policies for Mental Health during the COVID-19 Pandemic in the United States.

The COVID-19 pandemic spurred an economic downturn that may have eroded population mental health, especially for renters and homeowners who experienced financial hardship and were at risk of housing loss. Using household-level data from the Census Bureau's Household Pulse Survey (n = 805,223; August 2020-August 2021) and state-level data on eviction/foreclosure bans, we estimated linear probability models with two-way fixed effects to (1) examine links between COVID-related financial hardship and anxiety/depression and (2) assess whether state eviction/foreclosure bans buffered the detrimental mental health impacts of financial hardship. Findings show that individuals who reported difficulty paying for household expenses and keeping up with rent or mortgage had increased anxiety and depression risks but that state eviction/foreclosure bans weakened these associations. Our findings underscore the importance of state policies in protecting mental health and suggest that heterogeneity in state responses may have contributed to mental health inequities during the pandemic.

Brief overview: cemiplimab for the treatment of advanced basal cell carcinoma: PD-1 strikes again.

Basal cell carcinoma (BCC) is the most common malignancy worldwide. Fortunately, most tumors are localized and easily amenable to surgical resection or locally destructive treatments. However, a subset of BCCs can become locally advanced or metastatic. The development of small-molecule inhibitors of smoothened, a protein in the hedgehog pathway, which is almost universally activated in BCCs, was a breakthrough in the treatment of patients with advanced BCC. However, these agents are associated with primary and secondary resistance and have a toxicity profile that makes long-term use difficult. The recent approval of cemiplimab for patients with advanced BCC who are resistant to or are intolerant of hedgehog inhibitor therapy fills a significant unmet need as these patients now have a viable, second-line systemic therapeutic option. This article summarizes the rationale and data leading to the approval for cemiplimab in advanced BCC.

Marriage, Kids, and the Picket Fence? Household Type and Wealth among U.S. Households, 1989 to 2019.

Evidence on how parenthood impacts household wealth in the United States has been inconclusive, partially because previous studies have decontextualized parenthood from gender, marital, and relationship status. Yet, insights from economic sociology suggest that wealth-related behaviors are shaped by the intersection of identities, not by a binary classification of parental status. We examine net worth by the intersection of gender, parental, and relationship status during a period of increasing wealth inequality and family diversification. Using data from the Survey of Consumer Finances from 1989 through 2019, we show that aggregate comparisons between parents and non-parents mask substantial wealth variation across nine household types. Despite changing social selection into marriage and parenthood, married parents consistently held a wealth advantage over demographically similar adults in other household types. Married parents' wealth advantage descriptively arises from homeownership, perhaps because the combined spousal and parental identities are normatively and culturally associated with homeownership.

Breastfeeding and the child cognitive outcomes: a propensity score matching approach.

To estimate the effect of breastfeeding initiation and duration on child development outcomes. 3,271 children and their mothers participating in the Child Development Supplement of the Panel Study of Income Dynamics provide data for these analyses. Main outcomes include Woodcock Johnson Psycho-Educational Battery-Revised (WJ-R) test score (letter word, passage comprehension, applied problem, and broad reading), and Wechsler Intelligence Scale for Children-Revised (WISC-R) test score at the 2002 survey. Controlled variables include family, maternal, and child characteristics, many of which can be traced back to the year the child was born. The analytic technique is propensity score matching with multiple imputations. After using propensity scores to adjust for confounding factors, breastfeeding initiation showed statistically significant effects but the practical scale remains small. Breastfeeding duration showed a non-linear effect on those outcomes and most of the effects are not significant. The effects of breastfeeding on child's cognitive outcomes are modest in practical terms. The non-linear effects suggest that selection into breastfeeding may account for the increased score of children who are breastfed.

Heightened immigration enforcement impacts US citizens' birth outcomes: Evidence from early ICE interventions in North Carolina.

We examine how increased Immigration and Customs Enforcement (ICE) activities impacted newborn health and prenatal care utilization in North Carolina around the time Section 287(g) of the Immigration and Nationality Act was first being implemented within the state. Focusing on administrative data between 2004 and 2006, we conduct difference-in-differences and triple-difference case-control regression analysis. Pregnancies were classified by levels of potential exposure to immigration enforcement depending on parental nativity and educational attainment. Contrast groups were foreign-born parents residing in nonadopting counties and all US-born non-Hispanic parents. The introduction of the program was estimated to decrease birth weight by 58.54 grams (95% confidence interval [CI], -83.52 to -33.54) with effects likely following from reduced intrauterine growth. These results are shown to coexist with a worsening in the timing of initiation and frequency of prenatal care received. Since birth outcomes influence health, education, and earnings trajectories, our findings suggest that the uptick in ICE activities can have large socioeconomic costs over US-born citizens.

COVID-19 Seroprevalence and Active Infection in an Asymptomatic Population.

In response to the COVID-19 pandemic, immediate and scalable testing solutions are needed to direct return to full capacity planning in the general public and across the Department of Defense (DoD). To fully understand the extent to which a population has been affected by COVID-19, active monitoring approaches require an estimation of overall seroprevalence in addition to accurate, affordable, and rapid tests to detect current SARS-CoV-2 infection. In this study, researchers in the Air Force Research Laboratory's 711th Human Performance Wing, Airman Systems Directorate evaluated the performance of various testing methods for the detection of SARS-CoV-2 antibodies and viral RNA in asymptomatic adults working at Wright-Patterson Air Force Base and the surrounding area during the period of 23 July 2020-23 Oct 2020. Altogether, there was a seroprevalance of 3.09% and an active infection rate of 0.5% (determined via the testing of saliva samples) amongst individuals tested, both of which were comparable to local and national averages at the time. This work also presents technical and non-technical assessments of various testing strategies as compared to the gold standard approaches (e.g., lateral flow assays vs. ELISA and RT-LAMP vs. RT-PCR) in order to explore orthogonal supply chains and fieldability. Exploration and validation of multiple testing strategies will allow the DoD and other workforces to make informed responses to COVID-19 and future pandemics.

Engineering probiotics for therapeutic applications: recent examples and translational outlook.

Engineered probiotics are the next generation of live biotherapeutics that have been genetically modified to target specific diseases. With the advancements in synthetic biology, the engineering of probiotics has become increasingly sophisticated which has led to the development of therapies for treating cancer, infection, metabolic disorders and inflammation, as well as for diagnosing and preventing them. Herein, we review some of the recent examples of probiotics which have been engineered to target such diseases. Although there are numerous examples of engineered probiotics showing efficacy in animal models, there are no approved products on the market with very few in clinical trials. Therefore, we also discuss a set of features that may be incorporated into engineered probiotics to aid in clinical translation and ultimately, realizing the potential of these biotherapeutics.

Social Class Divergence in Family Transitions: The Importance of Cohabitation.

OBJECTIVE: This study examined trends in familial transitions by maternal education and whether transitions rose because of changes in prevalence (the share of children exposed to a relationship state, either marriage or cohabitation) or churning (the number of entrances and exits conditional on being exposed to a relationship state). BACKGROUND: Children's experiences of transitions, an important predictor of well-being, have leveled off in recent decades. Plateauing in transitions may reflect heterogeneity by socioeconomic status. METHOD: Data came from the National Survey of Family Growth on firstborn children observed from ages 0 to 5 among mothers aged 15 to 34 at the time of the child's birth (N = 7,265). Kitagawa methods decomposed changes in transitions into those attributable to changes in prevalence and churning. Analyses were conducted separately by maternal education. RESULTS: Children born to lower and moderately educated women experienced an increase in transitions because cohabitation increased in prevalence rather than a change in the number of exits and entrances from cohabiting unions. Among this disadvantaged group, children exposed to cohabitation experienced much more churning than children exposed to marriage. Children born to mothers with a 4-year degree did not experience an increase in transitions and predominantly experienced stable parental marriages. CONCLUSION: Transitions only plateaued for children born to highly educated mothers, whereas transitions rose for less-advantaged children. Transitions appear to be another aspect of early family life experiences that contributes to diverging destinies.

Local Job Losses and Child Maltreatment: The Importance of Community Context.

A growing body of literature suggests that economic downturns predict an increase in child maltreatment. However, to inform policies and practices to prevent and intervene in child maltreatment, it is necessary to identify how, when, and under what conditions community-level economic conditions affect child maltreatment. In this study, we use North Carolina administrative data from 2006 to 2011 on child maltreatment reports and job losses to distinguish effects on maltreatment frequency from effects on severity, identify the timing of these effects, and test whether community characteristics moderate these effects. To isolate effects of unanticipated job losses and to control for potential confounding factors, we use a fixed effects regression approach. We find that, though job losses did not affect the frequency of reports, job losses increased the share of reports that were relatively severe. This effect endured for 9 months following job losses and was only evident in economically disadvantaged communities.

They Should Say "I Don't": Norms About Midpregnancy Marriage and Job Loss.

This study examined effects of local economic conditions on individuals' attitudes toward midpregnancy marriages using an experimental vignette method. Adults (N = 460) were each shown two vignettes about a hypothetical couple expecting a baby; within each vignette pair, vignettes randomly varied as to whether the couple lived in a community that had recently experienced job losses or had stable employment. Respondents indicated if the couple should and will get married before the baby's birth. Results showed that worse local economic conditions led people to believe that marriage would be less common. Among more socio-economically disadvantaged respondents, if the hypothetical couple lived in a community with job loss, fewer respondents also thought that the couple should marry. In contrast, among more socioeconomically advantaged respondents, slightly more respondents thought that the couple should marry. When economic conditions worsen, low-socioeconomic-status individuals may believe that financial prerequisites for marriage become harder to meet.

Connecting child care quality to child outcomes: drawing policy lessons from nonexperimental data.

Effective early childhood intervention and child care policies should be based on an understanding of the effects of child care quality and type on child well-being. This article describes methods for securing unbiased estimates of these effects from nonexperimental data. It focuses on longitudinal studies like the one developed by the National Institute of Child Health and Human Development's Early Child Care Research Network. This article first describes bias problems that arise in analyses of nonexperimental data and then explains strategies for controlling for biases arising from parental selection of child care. Next, it comments on attrition in longitudinal studies and outlines some strategies for addressing possible attrition bias. Finally, it discusses the need to translate "effect sizes" derived from these studies into the kinds of cost and benefit information needed by policy makers.

How Economic Downturns Affect Children's Development: An Interdisciplinary Perspective on Pathways of Influence.

To understand how economic downturns affect children's development, scholars have concentrated on how parents' loss of a job affects children's well-being, but have largely ignored the potential effects of downturns on children whose parents remain employed. In this article, we review research across disciplines to demonstrate that economic downturns should be conceptualized as a community-level event that affects all children in a community, not just those whose parents have lost jobs. We focus on three mechanisms linking downturns to children's developmental outcomes: structural changes to communities, the economic and psychological effects on individuals who are continuously employed, and the strain of job loss on social networks. We conclude by discussing ongoing research and looking at implications for public policy.

Photoinduced electron transfer in a supramolecular triad produced by porphyrin anion-induced electron transfer from tetrathiafulvalene calix[4]pyrrole to Li(+)@C60.

Binding of a porphyrin carboxylate anion () to tetrathiafulvalene calix[4]pyrrole (TTF-C4P) results in electron transfer from TTF-C4P to Li(+)@C60 to produce the charge-separated state (1/TTF-C4P˙(+)/Li(+)@C60˙(-)) in benzonitrile. Upon photoexcitation of , photoinduced electron transfer from the triplet excited state of to TTF-C4P˙(+) occurs to produce the higher energy charge-separated state (˙(+)/TTF-C4P/Li(+)@C60˙(-)), which decays to the ground state with a lifetime of 4.8 µs.