Detalhe da pesquisa
1.
Structure-based design of diarylpyrimidines and triarylpyrimidines as potent HIV-1 NNRTIs with improved metabolic stability and drug resistance profiles.
J Med Virol;
96(3): e29502, 2024 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38450817
2.
Discovery of low-molecular-weight phenylalanine derivatives as novel HIV capsid modulators with improved antiretroviral activity and metabolic stability.
J Med Virol;
96(4): e29594, 2024 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38576317
3.
Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility.
Bioorg Chem;
147: 107340, 2024 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38593532
4.
Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors.
Bioorg Chem;
148: 107495, 2024 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38805850
5.
Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy.
Molecules;
29(9)2024 May 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38731613
6.
Poor glycemic control in type-2 diabetic patients infected with hepatitis B: A retrospective propensity-matched study.
J Med Virol;
95(3): e28635, 2023 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36869780
7.
Immune repertoire sequencing reveals an abnormal adaptive immune system in COVID-19 survivors.
J Med Virol;
95(1): e28340, 2023 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36420584
8.
In situ click chemistry-based discovery of 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs by exploiting the tolerant region I in binding pocket.
Bioorg Med Chem;
96: 117484, 2023 12 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37976805
9.
Development of novel HEPT analogs featuring significantly improved anti-resistance potency against HIV-1 through chemical space exploration of the tolerant region I.
Bioorg Chem;
140: 106783, 2023 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37595396
10.
Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg Chem;
133: 106413, 2023 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36791619
11.
Improving the anti-HIV-1 activity and solubility of poorly water-soluble DAPYs by heteroaromatic replacement strategy: From naphthalene-DAPYs to quinoline-DAPYs.
Bioorg Chem;
140: 106821, 2023 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37659148
12.
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study.
Int J Mol Sci;
24(2)2023 Jan 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36674730
13.
A medicinal chemist who reshaped the antiviral drug industry: John Charles Martin (1951-2021).
Med Res Rev;
42(2): 647-653, 2022 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34636044
14.
Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein.
J Med Virol;
94(12): 5975-5986, 2022 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35949003
15.
Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV1 non-nucleoside reverse transcriptase inhibitors.
Bioorg Med Chem;
53: 116531, 2022 01 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34890994
16.
Structure-Based design of [(2-Hydroxyethoxy)methyl]-6-(phenylthio)-thymine derivatives as nonnucleoside HIV-1 reverse transcriptase Inhibitors: From HEPTs to Sulfinyl-substituted HEPTs.
Bioorg Chem;
126: 105880, 2022 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35649315
17.
Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19.
Immun Ageing;
19(1): 12, 2022 Mar 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35248063
18.
Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses.
Chem Soc Rev;
50(7): 4514-4540, 2021 Apr 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33595031
19.
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators.
Molecules;
27(23)2022 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36500508
20.
Design, Synthesis and Structure-Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction.
Molecules;
27(18)2022 Sep 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36144727