1.
Bioorg Med Chem Lett
; 29(7): 929-932, 2019 04 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30773432
RESUMO
In the course of a programme aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson's disease, a few hits from high throughput screening were identified and characterized. A combined optimization pointed to a very narrow and stringent structure activity relationship. A comprehensive program of optimization led to a potent and safe candidate drug displaying neuroprotective and anti-inflammatory activity in several in vitro and in vivo models.