Detalhe da pesquisa
1.
An activator of voltage-gated K+ channels Kv1.1 as a therapeutic candidate for episodic ataxia type 1.
Proc Natl Acad Sci U S A;
120(31): e2207978120, 2023 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37487086
2.
Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase, modulates glycosphingolipid metabolism and results therapeutically effective in experimental models of Huntington's disease.
Mol Ther;
31(1): 282-299, 2023 01 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36116006
3.
Brain-Periphery Interactions in Huntington's Disease: Mediators and Lifestyle Interventions.
Int J Mol Sci;
25(9)2024 Apr 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38731912
4.
Treatment with the Glycosphingolipid Modulator THI Rescues Myelin Integrity in the Striatum of R6/2 HD Mice.
Int J Mol Sci;
24(6)2023 Mar 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36983032
5.
Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import.
Hum Mol Genet;
29(3): 418-431, 2020 02 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31875875
6.
Decipher non-canonical SPAST splicing mutations with the help of functional assays in patients affected by spastic paraplegia 4 (SPG4).
Clin Genet;
102(2): 155-156, 2022 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35524423
7.
Polysialic Acid Sustains the Hypoxia-Induced Migration and Undifferentiated State of Human Glioblastoma Cells.
Int J Mol Sci;
23(17)2022 Aug 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36076963
8.
Acute manganese treatment restores defective autophagic cargo loading in Huntington's disease cell lines.
Hum Mol Genet;
28(22): 3825-3841, 2019 11 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31600787
9.
A Rationale for Hypoxic and Chemical Conditioning in Huntington's Disease.
Int J Mol Sci;
22(2)2021 Jan 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33430140
10.
Differential Expression of Sphingolipid Metabolizing Enzymes in Spontaneously Hypertensive Rats: A Possible Substrate for Susceptibility to Brain and Kidney Damage.
Int J Mol Sci;
22(7)2021 Apr 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33917593
11.
Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease.
Hum Mol Genet;
27(14): 2490-2501, 2018 07 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29688337
12.
Mitochondrial Respiration Changes in R6/2 Huntington's Disease Model Mice during Aging in a Brain Region Specific Manner.
Int J Mol Sci;
21(15)2020 Jul 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32751413
13.
Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders.
Int J Mol Sci;
21(22)2020 Nov 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33238365
14.
Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients.
Hum Genomics;
11(1): 30, 2017 Dec 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29216901
15.
Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model.
Biochim Biophys Acta Mol Basis Dis;
1863(6): 1596-1604, 2017 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28213125
16.
FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease.
Hum Mol Genet;
23(9): 2251-65, 2014 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24301680
17.
Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.
J Cell Mol Med;
19(11): 2540-8, 2015 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26094900
18.
Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.
Proc Natl Acad Sci U S A;
109(9): 3528-33, 2012 Feb 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22331905
19.
Abnormal expression of sphingolipid-metabolizing enzymes in the heart of spontaneously hypertensive rat models.
Biochim Biophys Acta Mol Cell Biol Lipids;
1869(1): 159411, 2024 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37949293
20.
ß-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage.
J Neurosci;
32(19): 6490-500, 2012 May 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22573671