Detalhe da pesquisa
1.
Pan AMPK Activation Protects Tubules in Rat Ischemic Acute Kidney Injury.
J Pharmacol Exp Ther;
2024 Jun 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38849142
2.
A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors.
Bioorg Med Chem Lett;
47: 128113, 2021 09 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33991628
3.
A Scalable Platform for Producing Recombinant Nucleosomes with Codified Histone Methyltransferase Substrate Preferences.
Protein Expr Purif;
164: 105455, 2019 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31306746
4.
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.
Nature;
492(7427): 108-12, 2012 Dec 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23051747
5.
Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition.
Bioorg Med Chem Lett;
27(21): 4838-4843, 2017 11 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28985999
6.
Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction.
Nat Chem Biol;
10(3): 181-7, 2014 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24390428
7.
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).
Proc Natl Acad Sci U S A;
109(8): 2989-94, 2012 Feb 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22323599
8.
Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor.
Commun Biol;
5(1): 787, 2022 08 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35931745
9.
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
ACS Med Chem Lett;
9(7): 736-740, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30034610
10.
A simple assay for detection of small-molecule redox activity.
J Biomol Screen;
12(6): 881-90, 2007 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17579124
11.
Long residence time inhibition of EZH2 in activated polycomb repressive complex 2.
ACS Chem Biol;
9(3): 622-9, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24304166
12.
Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens.
J Biomol Screen;
17(10): 1279-92, 2012 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22904200
13.
Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.
ACS Med Chem Lett;
3(12): 1091-6, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24900432