1.
Org Lett
; 6(26): 4941-4, 2004 Dec 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15606105
RESUMO
[reaction: see text] Herein, we report a diastereoselective synthesis of the natural product (2S,5R)-5-hydroxypipecolic acid and 6-substituted derivatives thereof. The key step in the synthetic sequence is a novel highly diastereoselective epoxidation reaction of an enantiomerically pure cyclic enamide intermediate.