RESUMO
A dithiolation of alkenyl sulfonium salts with arylthiols is described, affording a series of 1,2-dithioalkanes in high yields. This protocol features mild and catalyst-free conditions and involves the formation of two C-S bonds sequentially via the regioselective addition of an arylthiol to the unsaturated CâC bonds, followed by the attack of another arylthiol to form 1,2-dithioalkanes exclusively.
RESUMO
A highly diastereo- and enantioselective phosphinative cyclization of ketone-enamides with secondary diarylphosphines enabled by copper catalysis is reported, providing a range of chiral tertiary cyclohexylphosphines bearing three contiguous stereogenic centers in high yields. This asymmetric phosphination-aldol cyclization protocol can also be extended to desymmetrization of dione-enamides to create four contiguous stereogenic centers in a highly selective manner.
RESUMO
The crystal structure of the title compound, C(31)H(22)N(4)O(4), features weak C-Hâ¯O inter-actions. The dihedral angle between the fused benzene and furan rings is 2.49â (15)°, while that between the triazole and pyridine rings is 10.23(18)°.