Neurocognitive impairment in night and shift workers: a meta-analysis of observational studies.

OBJECTIVE: Shift work is an essential element of modern labour, ensuring ideal conditions of service for today's economy and society. Despite the beneficial properties, its impact on the neurobehavioural performance of exposed subjects remains controversial. This meta-analysis aimed to provide the first summarising effects regarding the association between shift work exposure and different cognitive functions. METHODS: A literature search was performed using the databases PubMed, PsyINFO, PsyARTICLES, MedLine, PsycNET and Scopus including eligible studies up to April 2021 that compared shift workers with non-shift workers regarding neurobehavioural performance tests. We carried out a random-effects model using Hedges' g as a meta-analytical effect size with a restricted likelihood estimator to summarise the mean differences between the exposure group and controls. Positive effect sizes indicate higher performance for non-shift workers. The heterogeneity of effect sizes was addressed by sensitivity analysis using funnel plots, Egger's tests, p-curve analysis, meta-regressions and subgroup analysis. RESULTS: We included 18 studies resulting in a total sample of 18 802 participants and 37 effect sizes concerning six different neurobehavioural outcomes. Our results showed significantly worse performance in shift workers compared with non-shift workers in the following cognitive functions with g (95% CI): processing speed 0.16 (0.02 to 0.30), working memory 0.28 (0.51 to 0.50), psychomotor vigilance 0.21 (0.05 to 0.37), cognitive control 0.86 (0.45 to 1.27) and visual attention 0.19 (0.11 to 0.26). CONCLUSIONS: We provide the first meta-analytical findings that associate shift work with decreased cognitive performance in processing speed, working memory, psychomotor vigilance, cognitive control and visual attention.

Manganese exposure and cognitive performance: A meta-analytical approach.

Occupational manganese exposure is associated with serious health concerns, ultimately leading to an illness called manganism. Competing meta-analytic results were published over a decade ago, ranging from undetectable to serious effects on cognitive performance among working adults. Novel studies and findings about the relationship between occupational manganese and cognitive functions have been proposed since. First of all, a systematic literature search was carried out until October 2022 via multiple electronic databases investigating the relationship between occupational manganese exposure and cognitive functions. Differences between the exposure and control groups in cognitive testing were synthesized by effect size Hedge's g. A random effects model was deployed with a restricted likelihood estimator using Hedges' invariance weighting. Publication bias, p-hacking and exposure-effect relationships were investigated. We included 18 studies with 75 effect sizes comparing n = 888 controls and 1092 exposed participants. After exclusion of outliers, we found significantly lower performances in processing speed, attention, working memory, reaction time, cognitive control and visual attention in workers exposed to manganese. Regression analysis revealed an indication of exposure-effect relationships between manganese exposure and cognitive functioning in exposed workers. We provide results of impaired cognitive functions for working adults exposed to manganese in processing speed, attention, working memory, reaction time and visual attention. Indications of quadratic exposure-effect relationships are discussed. We provide several recommendations for further studies to investigate possible exposure effects in the context of occupational health and safety.

Mating Performance and Singlehood Across 14 Nations.

Adult individuals frequently face difficulties in attracting and keeping mates, which is an important driver of singlehood. In the current research, we investigated the mating performance (i.e., how well people do in attracting and retaining intimate partners) and singlehood status in 14 different countries, namely Austria, Brazil, China, Greece, Hungary, Italy, Japan, Peru, Poland, Russia, Spain, Turkey, the UK, and Ukraine (N = 7,181). We found that poor mating performance was in high occurrence, with about one in four participants scoring low in this dimension, and more than 57% facing difficulties in starting and/or keeping a relationship. Men and women did not differ in their mating performance scores, but there was a small yet significant effect of age, with older participants indicating higher mating performance. Moreover, nearly 13% of the participants indicated that they were involuntarily single, which accounted for about one-third of the singles in the sample. In addition, more than 15% of the participants indicated that they were voluntarily single, and 10% were between-relationships single. We also found that poor mating performance was associated with an increased likelihood of voluntary, involuntary, and between-relationships singlehood. All types of singlehood were in higher occurrence in younger participants. Although there was some cross-cultural variation, the results were generally consistent across samples.