Which leadership style do more narcissistic subordinates prefer in supervisors?

BACKGROUND AND OBJECTIVE: Subordinates in Western cultures generally prefer supervisors with a democratic rather than autocratic leadership style. It is unclear, however, whether more narcissistic subordinates share or challenge this prodemocratic default attitude. On the one hand, more narcissistic individuals strive for power and thus may favor a democratic supervisor, who grants them power through participation. On the other hand, similarity attracts and, thus, more narcissistic subordinates may favor an autocratic supervisor, who exhibits the same leadership style that they would adopt in a leadership position. METHOD: Four studies (Ntotal = 1284) tested these competing hypotheses with two narcissism dimensions: admiration and rivalry. Participants indicated the leadership style they generally prefer in a supervisor (Study 1), rated their own supervisor's leadership style (Study 2a: individual ratings; Study 2b: team ratings), and evaluated profiles of democratic and autocratic supervisors (Study 3). RESULTS: We found a significantly weaker prodemocratic default attitude among more narcissistic subordinates: Subordinates' narcissism was negatively related to endorsement of democratic supervisors and positively related to endorsement of autocratic supervisors. Those relations were mostly driven by narcissistic rivalry rather than narcissistic admiration. CONCLUSION: The results help clarify the narcissistic personality and, in particular, how more narcissistic subordinates prefer to be led.

The Well-Being Benefits of Person-Culture Match Are Contingent on Basic Personality Traits.

People enjoy well-being benefits if their personal characteristics match those of their culture. This person-culture match effect is integral to many psychological theories and-as a driver of migration-carries much societal relevance. But do people differ in the degree to which person-culture match confers well-being benefits? In the first-ever empirical test of that question, we examined whether the person-culture match effect is moderated by basic personality traits-the Big Two and Big Five. We relied on self-reports from 2,672,820 people across 102 countries and informant reports from 850,877 people across 61 countries. Communion, agreeableness, and neuroticism exacerbated the person-culture match effect, whereas agency, openness, extraversion, and conscientiousness diminished it. People who possessed low levels of communion coupled with high levels of agency evidenced no well-being benefits from person-culture match, and people who possessed low levels of agreeableness and neuroticism coupled with high levels of openness, extraversion, and conscientiousness even evidenced well-being costs. Those results have implications for theories building on the person-culture match effect, illuminate the mechanisms driving that effect, and help explain failures to replicate it.

YB-1-based oncolytic virotherapy in combination with CD47 blockade enhances phagocytosis of pediatric sarcoma cells.

Oncolytic viruses (OVs) selectively replicate in tumor cells resulting in lysis, spreading of new infectious units and induction of antitumor immune responses through abrogating an immunosuppressive tumor microenvironment (TME). Due to their mode of action, OVs are ideal combination partners with targeted immunotherapies. One highly attractive combination is the inhibition of the 'don't-eat-me'-signal CD47, which is known to increase the phagocytic potential of tumor-associated macrophages. In this work, we analyzed the combination approach consisting of the YB-1-based oncolytic adenovirus XVir-N-31 (XVir) and the CD47 inhibitor (CD47i) B6.H12.2 concerning its phagocytic potential. We investigate phagocytosis of XVir-, adenovirus wildtype (AdWT)-, and non-infected established pediatric sarcoma cell lines by different monocytic cells. Phagocytes (immature dendritic cells and macrophages) were derived from THP-1 cells and healthy human donors. Phagocytosis of tumor cells was assessed via FACS analysis in the presence and absence of CD47i. Additional characterization of T cell-stimulatory surface receptors as well as chemo-/cytokine analyses were performed. Furthermore, tumor cells were infected and studied for the surface expression of the 'eat-me'-signal calreticulin (CALR) and the 'don't-eat-me'-signal CD47. We herein demonstrate that (1) XVir-infected tumor cells upregulate both CALR and CD47. XVir induces higher upregulation of CD47 than AdWT. (2) XVir-infection enhances phagocytosis in general and (3) the combination of XVir and CD47i compared to controls showed by far superior enhancement of phagocytosis, tumor cell killing and innate immune activation. In conclusion, the combination of CD47i and XVir causes a significant increase in phagocytosis exceeding the monotherapies considerably accompanied by upregulation of T cell-stimulatory receptor expression and inflammatory chemo/-cytokine secretion.

TCR-transgenic T cells and YB-1-based oncolytic virotherapy improve survival in a preclinical Ewing sarcoma xenograft mouse model.

Background: Ewing sarcoma (EwS) is an aggressive and highly metastatic bone and soft tissue tumor in pediatric patients and young adults. Cure rates are low when patients present with metastatic or relapsed disease. Therefore, innovative therapy approaches are urgently needed. Cellular- and oncolytic virus-based immunotherapies are on the rise for solid cancers. Methods: Here, we assess the combination of EwS tumor-associated antigen CHM1319-specific TCR-transgenic CD8+ T cells and the YB-1-driven (i.e. E1A13S-deleted) oncolytic adenovirus XVir-N-31 in vitro and in a xenograft mouse model for antitumor activity and immunostimulatory properties. Results: In vitro both approaches specifically kill EwS cell lines in a synergistic manner over controls. This effect was confirmed in vivo, with increased survival using the combination therapy. Further in vitro analyses of immunogenic cell death and antigen presentation confirmed immunostimulatory properties of virus-infected EwS tumor cells. As dendritic cell maturation was also increased by XVir-N-31, we observed superior proliferation of CHM1319-specific TCR-transgenic CD8+ T cells only in virus-tested conditions, emphasizing the superior immune-activating potential of XVir-N-31. Conclusion: Our data prove synergistic antitumor effects in vitro and superior tumor control in a preclinical xenograft setting. Combination strategies of EwS-redirected T cells and YB-1-driven virotherapy are a highly promising immunotherapeutic approach for EwS and warrant further evaluation in a clinical setting.

The Oncolytic Adenovirus XVir-N-31 Joins Forces with CDK4/6 Inhibition Augmenting Innate and Adaptive Antitumor Immunity in Ewing Sarcoma.

PURPOSE: Ewing sarcoma (EwS) is a highly malignant pediatric tumor characterized by a non-T-cell-inflamed immune-evasive phenotype. When relapsed or metastasized, survival is poor, emphasizing the need for novel treatment strategies. Here, we analyze the novel combination approach using the YB-1-driven oncolytic adenovirus XVir-N-31 and CDK4/6 inhibition to augment EwS immunogenicity. EXPERIMENTAL DESIGN: In vitro, viral toxicity, replication, and immunogenicity were studied in several EwS cell lines. In vivo tumor xenograft models with transient humanization were applied to evaluate tumor control, viral replication, immunogenicity, and dynamics of innate as well as human T cells after treatment with XVir-N-31 combined with CDK4/6 inhibition. Furthermore, immunologic features of dendritic cell maturation and T-cell-stimulating capacities were assessed. RESULTS: The combination approach significantly increased viral replication and oncolysis in vitro, induced HLA-I upregulation, and IFNγ-induced protein 10 expression and enhanced maturation of monocytic dendritic cells with superior capacities to stimulate tumor antigen-specific T cells. These findings were confirmed in vivo showing tumor infiltration by (i) monocytes with antigen-presenting capacities and M1 macrophage marker genes, (ii) TReg suppression in spite of adenovirus infection, (iii) superior engraftment, and (iv) tumor infiltration by human T cells. Consequently, survival was improved over controls with signs of an abscopal effect after combination treatment. CONCLUSIONS: The joint forces of the YB-1-driven oncolytic adenovirus XVir-N-31 and CDK4/6 inhibition induce therapeutically relevant local and systemic antitumor effects. Innate as well as adaptive immunity against EwS is boosted in this preclinical setting, pointing toward high therapeutic potential in the clinic.

A sociocultural norm perspective on Big Five prediction.

The Big Five predict numerous preferences, decisions, and behaviors-but why? To help answer this key question, the present research develops the sociocultural norm perspective (SNP) on Big Five prediction-a critical revision and extension of the sociocultural motives perspective. The SNP states: Agreeableness, Extraversion, and Conscientiousness predict outcomes positively if those outcomes are socioculturally normative. Openness, by contrast, predicts outcomes negatively if they are socioculturally normative. Moreover, the SNP specifies unique mechanisms that underlie those predictions. Two mechanisms are social (social trust for Agreeableness, social attention for Extraversion) and two are cognitive (rational thought for Conscientiousness, independent thought for Openness). The present research develops the SNP by means of three large-scale experiments (Ntotal = 7,404), which used a new, tailor-made experimental paradigm-the minimal norm paradigm. Overall, the SNP provides norm-based, culture-focused, and mechanism-attentive explanations for why the Big Five predict their outcomes. The SNP also has broader relevance: It helps explain why Big Five effects vary across cultures and, thus, dispels the view that such variation threatens the validity of the Big Five. It suggests that the psychology of norms would benefit from attention to the Big Five. Finally, it helps bridge personality, social, and cross-cultural psychology by integrating their key concepts-the Big Five, conformity, and sociocultural norms. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Monocyte Maturation Mediators Upregulate CD83, ICAM-1 and MHC Class 1 Expression on Ewing's Sarcoma, Enhancing T Cell Cytotoxicity.

Ewing's sarcoma (EwS) is a pediatric solid tumor entity with low somatic mutational burden and a low rate of tumor-infiltrating T cells, indicating a low extent of immunogenicity. In EwS, immunogenicity may furthermore be significantly diminished by a predominantly M2 macrophage driven pro-tumorigenic tumor microenvironment. In the past, we demonstrated that CHM1319-specific TCR-transgenic T cells are able to control EwS growth in a preclinical mouse model as well as in a patient with metastatic disease. However, new adjuvant techniques to induce long lasting and curative CHM1319-specific TCR-transgenic T cell-mediated anti-tumor responses are needed. In this work, we sought to identify a technique to improve the cytotoxic effect of CHM1319-specific TCR-transgenic T cell by altering the immunogenic cell surface marker expression on EwS cell lines using different cytokines. We demonstrate that TNF, IL-6, IL-1ß and PGE2 cause pro-immunogenic CD83, MHC class I and II as well as ICAM-1 upregulation in EwS cell lines. This observation was associated with significantly improved recognition and killing of the tumor cells by EwS-specific CHM1319/HLA-A*02:01-restricted TCR-transgenic T cells. Conclusively, we demonstrate that the induction of an inflammatory signature renders EwS more susceptible to adoptive T cell therapy. TNF, which is upregulated during inflammatory processes, is of particular translational interest as its secretion may be induced in the patients e.g., by irradiation and hyperthermia in the clinical setting. In future clinical protocols, this finding may be important to identify appropriate conditioning regimens as well as point of time for adoptive T cell-based immunotherapy in EwS patients.

Big Five facets and religiosity: Three large-scale, cross-cultural, theory-driven, and process-attentive tests.

How relevant are the Big Five in predicting religiosity? Existing evidence suggests that the Big Five domains account for only a small amount of variance in religiosity. Some researchers have claimed that the Big Five domains are too broad and not sufficiently specific to explain much religiosity variance. Accordingly, they speculated that the more specific Big Five facets should predict religiosity better. Yet, such research has generally been sparse, monocultural, descriptive, process-inattentive, and somewhat contradictory in its results. Therefore, we conducted three large-scale, cross-cultural, theory-driven, and process-attentive studies. Study 1 (N = 2,277,240) used self-reports across 96 countries, Study 2 (N = 555,235) used informant-reports across 57 countries, and Study 3 (N = 1,413,982) used self-reports across 2,176 cities, 279 states, and 29 countries. Our results were highly consistent across studies. Contrary to widespread assumptions, the Big Five facets did not explain substantially more variance in religiosity than the Big Five domains. Moreover, culture was much more important than previously assumed. More specifically, the Big Five facets collectively explained little variance in religiosity in the least religious cultural contexts (4.2%) but explained substantial variance in religiosity in the most religious cultural contexts (19.5%). In conclusion, the Big Five facets are major predictors of religiosity, but only in religious cultural contexts. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

When and Why Being Ostracized Affects Veracity Judgments.

Ostracism-being ignored and excluded by others-is a ubiquitous experience with adverse effects on well-being. To prevent further exclusion and regain belonging, ostracized individuals are well advised to identify affiliation partners who are sincerely well-disposed. Humans' ability to detect lies, however, is generally not very high. Yet, veracity judgments can become more accurate with decreasing reliance on common stereotypic beliefs about the nonverbal behavior of liars and truth-tellers. We hypothesize that ostracized (vs. included) individuals base their veracity judgments less on such stereotypical nonverbal cues if message content is affiliation-relevant. In line with this hypothesis, Experiment 1 shows that ostracized (vs. included) individuals are better at discriminating affiliation-relevant lies from truths. Experiments 2 and 3 further show that ostracized (vs. included) individuals base their veracity judgments less on stereotypical nonverbal cues if messages are of high (but not low) affiliation relevance.

The effects of a passive exoskeleton on muscle activity, discomfort and endurance time in forward bending work.

Exoskeletons may form a new strategy to reduce the risk of developing low back pain in stressful jobs. In the present study we examined the potential of a so-called passive exoskeleton on muscle activity, discomfort and endurance time in prolonged forward-bended working postures. Eighteen subjects performed two tasks: a simulated assembly task with the trunk in a forward-bended position and static holding of the same trunk position without further activity. We measured the electromyography for muscles in the back, abdomen and legs. We also measured the perceived local discomfort. In the static holding task we determined the endurance, defined as the time that people could continue without passing a specified discomfort threshold. In the assembly task we found lower muscle activity (by 35-38%) and lower discomfort in the low back when wearing the exoskeleton. Additionally, the hip extensor activity was reduced. The exoskeleton led to more discomfort in the chest region. In the task of static holding, we observed that exoskeleton use led to an increase in endurance time from 3.2 to 9.7 min, on average. The results illustrate the good potential of this passive exoskeleton to reduce the internal muscle forces and (reactive) spinal forces in the lumbar region. However, the adoption of an over-extended knee position might be, among others, one of the concerns when using the exoskeleton.