Detalhe da pesquisa
1.
Glucagon blockade restores functional ß-cell mass in type 1 diabetic mice and enhances function of human islets.
Proc Natl Acad Sci U S A;
118(9)2021 03 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33619103
2.
Catechol estrogens stimulate insulin secretion in pancreatic ß-cells via activation of the transient receptor potential A1 (TRPA1) channel.
J Biol Chem;
294(8): 2935-2946, 2019 02 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30587572
3.
Discovery of LY3325656: A GPR142 agonist suitable for clinical testing in human.
Bioorg Med Chem Lett;
30(5): 126857, 2020 03 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31982234
4.
Ectonucleotidase NTPDase3 is abundant in pancreatic ß-cells and regulates glucose-induced insulin secretion.
Am J Physiol Endocrinol Metab;
305(10): E1319-26, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24085034
5.
Regulation of GPR119 receptor activity with endocannabinoid-like lipids.
Am J Physiol Endocrinol Metab;
303(12): E1469-78, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23074242
6.
A High-Throughput Assay for the Pancreatic Islet Beta-Cell Potassium Channel: Use in the Pharmacological Characterization of Insulin Secretagogues Identified from Phenotypic Screening.
Assay Drug Dev Technol;
19(1): 27-37, 2021 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33164547
7.
BACH2 inhibition reverses ß cell failure in type 2 diabetes models.
J Clin Invest;
131(24)2021 12 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34907913
8.
GPR142 prompts glucagon-like Peptide-1 release from islets to improve ß cell function.
Mol Metab;
11: 205-211, 2018 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29506910
9.
Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.
Endocrinology;
148(4): 1843-9, 2007 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17194744
10.
Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.
Diabetes;
55(9): 2470-8, 2006 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16936195
11.
Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.
Endocrinology;
147(8): 3898-905, 2006 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16644917
12.
GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism.
PLoS One;
11(6): e0157298, 2016.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27322810
13.
A novel glucokinase activator modulates pancreatic islet and hepatocyte function.
Endocrinology;
146(9): 3696-701, 2005 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15919746
14.
Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells.
Diabetes;
53 Suppl 3: S75-8, 2004 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15561926
15.
Two generations of insulinotropic imidazoline compounds.
Diabetes;
51 Suppl 3: S448-54, 2002 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12475789
16.
The PDZ/coiled-coil domain containing protein PIST modulates insulin secretion in MIN6 insulinoma cells by interacting with somatostatin receptor subtype 5.
FEBS Lett;
579(28): 6305-10, 2005 Nov 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16263117
17.
Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells.
FEBS Lett;
531(2): 199-203, 2002 Nov 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12417312
18.
Activation of prostaglandin E receptor 4 triggers secretion of gut hormone peptides GLP-1, GLP-2, and PYY.
Endocrinology;
154(1): 45-53, 2013 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23142807
19.
Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta.
Proc Natl Acad Sci U S A;
102(29): 10303-8, 2005 Jul 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16014415
20.
Secretory phospholipase A2 is released from pancreatic beta-cells and stimulates insulin secretion via inhibition of ATP-dependent K+ channels.
Biochem Biophys Res Commun;
310(2): 274-9, 2003 Oct 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14521906