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1.
AIDS Behav ; 26(12): 3991-4003, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35788925

RESUMO

We piloted a community-based intervention to improve outcomes among adolescents living with HIV who were transitioning to adult-oriented care in Lima, Peru. We assessed feasibility and potential effectiveness, including within-person changes in self-reported adherence, psychosocial metrics (NIH Toolbox), and transition readiness ("Am I on TRAC" questionnaire, "Got Transition" checklist). From October 2019 to January 2020, we enrolled 30 adolescents (15-21 years). The nine-month intervention consisted of logistical, adherence and social support delivered by entry-level health workers and group sessions to improve health-related knowledge and skills and social support. In transition readiness, we observed within-person improvements relative to baseline. We also observed strong evidence of improvements in adherence, social support, self-efficacy, and stress, which were generally sustained three months post-intervention. All participants remained in treatment after 12 months. The intervention was feasible and potentially effective for bridging the transition to adult HIV care. A large-scale evaluation, including biological endpoints, is warranted.


RESUMEN: Piloteamos una intervención comunitaria para mejorar los resultados de adolescentes viviendo con el VIH que se encontraban en transición a la atención de VIH orientada a adultos en Lima, Perú. Evaluamos la viabilidad y la eficacia potencial, incluidos los cambios personales en la adherencia auto-reportada, criterios psicosociales (NIH Toolbox), y preparación para la transición (cuestionario "Estoy en el TRAC", lista de verificación "Got Transition"). Desde octubre de 2019 hasta enero de 2020, enrolamos a 30 adolescentes (15 a 21 años). La intervención de nueve meses consistió en apoyo logístico, de adherencia y social brindado por técnicos de enfermería y sesiones grupales para mejorar tanto el conocimiento y las habilidades relacionados con la salud, como el apoyo social. En cuanto a la preparación para la transición, observamos mejoras comparada con el basal. También observamos una fuerte evidencia de mejoras en la adherencia, apoyo social, autoeficacia y estrés, que se mantuvieron, generalmente, tres meses después del fin de la intervención. Todos los participantes seguían en tratamiento después de 12 meses. La intervención fue factible y potencialmente efectiva para tender un puente en la transición a la atención del VIH para adultos. Esto amerita una evaluación a mayor escala y que incluya criterios clínicos.


Assuntos
Infecções por HIV , Adulto , Adolescente , Humanos , Projetos Piloto , Infecções por HIV/terapia , Infecções por HIV/psicologia , Peru/epidemiologia , Apoio Social , Autoeficácia
2.
J Adolesc Health ; 74(2): 260-267, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37804297

RESUMO

PURPOSE: Published data on outcomes among adolescents newly initiating antiretroviral treatment in the Latin American context are sparse. We estimated the frequency of sustained retention with viral load suppression (i.e., successful transition) and identified predictors of successful transition into adult care among youth (aged 14-21 years) with recently acquired HIV in Lima, Peru. METHODS: A retrospective cohort study was conducted among 184 adolescents and young adults who initiated antiretroviral therapy in an adult public sector HIV clinic between June 2014 and June 2019. Sustained retention (no loss-to-follow-up or death) with viral suppression was calculated for the first 12 and 24 months following treatment initiation. We conducted regression analyses to assess factors associated with successful transition to adult HIV care, including gender, age, occupation, nationality, pregnancy, same-sex sexual behavior, presence of treatment supporter, number of living parents, and social risk factors that may adversely influence health (e.g., lack of social support, economic deprivation). RESULTS: Patients were predominantly male (n = 167, 90.8%). Median age was 19 years (interquartile range: 18-21). Frequency of sustained retention with viral load suppression was 42.4% (78/184) and 35.3% (30/85) at 12 and 24 months following treatment initiation. In multivariable analyses, working and/or studying was inversely associated with successful transition into adult care at 12 months; number of known living parents (relative risk: 2.20; 95% confidence interval: 1.12, 4.34) and absence of social risk factors (relative risk: 1.68; 95% confidence interval: 0.91, 3.11) were positively associated with successful transition at 24 months. DISCUSSION: Sustained retention in HIV care was uncommon. Parental support and interventions targeting social risk factors may contribute to successful transition into adult HIV care in this group.


Assuntos
Fármacos Anti-HIV , Infecções por HIV , Gravidez , Feminino , Adulto Jovem , Humanos , Masculino , Adolescente , Adulto , Resultado do Tratamento , Estudos Retrospectivos , Peru , Infecções por HIV/tratamento farmacológico , Fármacos Anti-HIV/uso terapêutico , Carga Viral
3.
BMJ Open ; 12(4): e050457, 2022 04 29.
Artigo em Inglês | MEDLINE | ID: mdl-35487706

RESUMO

OBJECTIVES: This mixed-method study aimed to understand the effectiveness of linkage to biopsy and treatment in women with a high-risk mammography result (Breast Imaging Reporting and Data System, BI-RADS 4 and 5) in the national telemammography programme and to explore women's experiences during this process. SETTING: Quantitative component: we collected and linked health data from the telemammography reading centre, the national public health insurance, the national centre for disease control and the national referral cancer centre. Qualitative component: we interviewed participants from different regions of the country representing diverse social and geographical backgrounds. PARTICIPANTS: Quantitative: women who underwent telemammography between July 2017 and September 2018 and had high-risk results (BI-RADS 4-5) were collected. Qualitative: women with a high-risk telemammography result, healthcare providers and administrators. OUTCOMES MEASURES: Quantitative: we determined biopsy and treatment linkage rates and delays. Qualitative: we explored barriers and facilitators for obtaining a biopsy and initiating treatment. RESULTS: Of 126 women with high-risk results, 48.4% had documentation of biopsy and 37.5% experienced a delay of >45 days to biopsy. Of 51 women diagnosed with breast cancer, 86.4% had evidence of treatment initiation, but 69.2% initiated treatment >45 days after biopsy. Travelling to major cities for care, administrative factors and breast cancer misconceptions, among other factors, impeded timely, continuous care for breast cancer. A multidisciplinary and culturally tailored patient education facilitated understanding of the disease and prompt decision making about subsequent medical care. CONCLUSIONS: Strengthened breast cancer care capacity outside the capital city, standardised referral pathways, ensured financial support for travel expenses, and enhanced patient education are required to secure linkage to the breast cancer care continuum. Robust information systems are needed to track patients and to evaluate the programme's performance.


Assuntos
Neoplasias da Mama , Biópsia , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/terapia , Feminino , Humanos , Masculino , Mamografia/métodos , Peru
4.
J Int AIDS Soc ; 25(10): e26019, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36251163

RESUMO

INTRODUCTION: Adolescents living with HIV (ALWH) experience higher mortality rates compared to other age groups, exacerbated by the suboptimal transition from paediatric to adult HIV care, during which decreased adherence to antiretroviral therapy (ART) and unsuppressed viremia are frequent. Care transition-a process lasting months or years-ideally prepares ALWH for adult care and can be improved by interventions that are youth-friendly and address psychosocial issues affecting ART adherence; however, such interventions are infrequently operationalized. Community-based accompaniment (CBA), in which laypeople provide individualized support and health system navigation, can improve health outcomes among adults with HIV. Here, we describe patient and provider perceptions of a novel HIV CBA intervention called "PASEO" for ALWH in Lima, Peru. METHODS: PASEO consisted of six core elements designed to support ALWH during and after the transition to adult HIV care. During 2019-2021, community-based health workers provided tailored accompaniment for ALWH aged 15-21 years over 9 months, after which adolescent participants were invited to provide feedback in a focus group or in-depth interview. HIV care personnel were also interviewed to understand their perspectives on PASEO. A semi-structured interview guide probing known acceptability constructs was used. Qualitative data were analysed using a framework analysis approach and emergent themes were summarized with illustrative quotes. RESULTS: We conducted five focus groups and 11 in-depth interviews among N = 26 ALWH and nine key-informant interviews with HIV care personnel. ALWH participants included males, females and one transgender female, and those with both early childhood and recent HIV infection. ALWH praised PASEO, attributing increased ART adherence to the project. Improved mental health, independence, self-acceptance and knowledge on how to manage their HIV were frequently cited. HIV professionals similarly voiced strong support for PASEO. Both ALWH and HIV professionals expressed hope that PASEO would be scaled. HIV professionals voiced concerns regarding financing PASEO in the future. CONCLUSIONS: A multicomponent CBA intervention to increase ART adherence among ALWH in Peru was highly acceptable by ALWH and HIV programme personnel. Future research should determine the efficacy and economic impact of the intervention.


Assuntos
Infecções por HIV , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Grupos Focais , Infecções por HIV/psicologia , Humanos , Masculino , Adesão à Medicação , Saúde Mental , Cooperação do Paciente , Peru , Pesquisa Qualitativa
5.
Artigo em Inglês | MEDLINE | ID: mdl-34104457

RESUMO

BACKGROUND: Adolescents living with HIV (ALWH) are disproportionally impacted by depression, experiencing worse HIV outcomes. Integrated depression and HIV care may support antiretroviral adherence. This study pilot tested for proof of concept a basic depression care pathway for ALWH to inform depression care integration with HIV services in Peru. METHODS: ALWH were screened for depression with the Patient Health Questionnaire-9 (PHQ-9). Participants with PHQ-9 scores of ⩾10 or suicidal ideation (SI) were eligible for Psychological First Aid (PFA) delivered by non-mental health specialists. Participants with PHQ-9 re-assessments of ⩾20 or SI were referred to specialized services. RESULTS: Twenty-eight (11 female, 17 male) ALWH aged 15-21 years participated; n = 20 (71%) identified as heterosexual. Most (18/28) acquired HIV at birth. Baseline PHQ-9 scores were 0-4, n = 3 (11%); 5-9, n = 9 (32%); 10-14, n = 10 (36%); 15-19, n = 4 (14%); and 20-27, n = 2 (7%). Eleven participants (40%) reported SI. Among participants with PHQ-9 > 4, 92% (23/25) were not severe. Of the 21 (75%) of participants eligible for PFA, n = 9 (32%) accepted at least one session, of which n = 3 (33%) were linked to specialized care. CONCLUSIONS: A simple care pathway operationalizing depression screening and non-specialist delivered emotional support is a first step toward integrated depression and HIV care for ALWH.

6.
Rev Peru Med Exp Salud Publica ; 38(1): 153-158, 2021.
Artigo em Espanhol | MEDLINE | ID: mdl-34190908

RESUMO

Adolescents living with HIV (ALWH) have lower rates of virologic suppression and higher rates of immunologic decline compared to their older counterparts, potentially placing them at high-risk for developing severe SARS-CoV-2 disease. ALWH who are transitioning to adult care face additional challenges to remaining in care and adhering to treatment. In this special section we report the experiences of ALWH in the process of transitioning to adult HIV services during the COVID-19 pandemic. In first place, the government-mandated stay-at-home order has substantially limited access to full HIV care by restricting public transportation, HIV medication stock-outs, and the suspension of routine medical and laboratory appointments. In addition, financial hardship, uncertainty about their future plans, emotional stressors, lifestyle disruptions, and concerns of involuntary disclosure have further challenged continuity in care for this adolescent population.


Los adolescentes que viven con el VIH (AVVIH) tienen tasas más bajas de supresión virológica y tasas más altas de deterioro inmunológico en comparación con sus contrapartes mayores, colocándolos potencialmente en alto riesgo de enfermedad severa por SARS-CoV-2. Los AVVIH que están transicionando hacia el cuidado de adultos enfrentan dificultades adicionales para permanecer en el cuidado y adherirse al tratamiento antirretroviral. En esta sección especial reportamos el impacto observado en AVVIH transicionando al servicio de VIH para adultos durante la pandemia por SARS-CoV-2. En primer lugar, el acceso a la atención del VIH se ha visto perjudicado por la restricción del transporte público, la falta de antirretrovirales, y la suspensión de citas médicas y laboratoriales. Adicionalmente, dificultades financieras, incertidumbre sobre el futuro, estresores emocionales, alteración del estilo de vida y el temor de divulgar el diagnóstico involuntariamente han desafiado aún más la continuidad en la atención de esta población adolescente.


Assuntos
COVID-19 , Infecções por HIV , Adolescente , Adulto , Infecções por HIV/epidemiologia , Humanos , Pandemias , Peru/epidemiologia , SARS-CoV-2
7.
Am J Trop Med Hyg ; 101(3): 636-640, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31309921

RESUMO

Children in the Peruvian Amazon Basin are at risk of soil-transmitted helminths (STH) infections. This study aimed to determine the prevalence of STH infection in children from a rural Amazonian community of Peru and to elucidate epidemiological risk factors associated with its perpetuation while on a school-based deworming program with mebendazole. Stool samples of children aged 2-14 years and their mothers were analyzed through direct smear analysis, Kato-Katz, spontaneous sedimentation in tube, Baermann's method, and agar plate culture. A questionnaire was administered to collect epidemiological information of interest. Among 124 children, 25.8% had one or more STH. Individual prevalence rates were as follows: Ascaris lumbricoides, 16.1%; Strongyloides stercoralis, 10.5%; hookworm, 1.6%; and Trichuris trichiura, (1.6%). The prevalence of common STH (A. lumbricoides, T. trichiura, and hookworm) was higher among children aged 2-5 years than older children (31.6% versus 12.8%; P = 0.01). In terms of sanitation deficits, walking barefoot was significantly associated with STH infection (OR = 3.28; CI 95% = 1.11-12.07). Furthermore, STH-infected children more frequently had a mother who was concomitantly infected by STH than the non-STH-infected counterpart (36.4% versus 14.1%, P = 0.02). In conclusion, STH infection is highly prevalent in children from this Amazonian community despite routine deworming. Institutional health policies may include hygiene and sanitation improvements and screening/deworming of mothers to limit the dissemination of STH. Further studies are needed to address the social and epidemiological mechanics perpetuating these infections.


Assuntos
Fezes/parasitologia , Helmintíase/epidemiologia , Helmintíase/transmissão , População Rural , Solo/parasitologia , Adolescente , Animais , Anti-Helmínticos/uso terapêutico , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Masculino , Mebendazol/uso terapêutico , Mães , Peru/epidemiologia , Prevalência , Fatores de Risco , Saneamento
8.
PLoS One ; 12(8): e0181412, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28806412

RESUMO

INTRODUCTION: Based on the hypothesis that HIV programs struggle to deliver health services that harmonize necessities of treatment and prevention, we described the outcomes of routinely provided HIV testing to partners of people living with HIV (PLWH) through a secondary analysis of routine data collected at a public hospital in Lima, Peru. METHODS: Among PLWH enrolled in the study center's HIV program between 2005 and 2014, we identified index cases (IC): PLWH who reported a unique partner not previously enrolled. We grouped partners according to their HIV status as reported by IC and collected data on HIV testing, clinical characteristics and admissions. The main outcome was the frequency of HIV testing among partners with reported unknown/seronegative HIV status. RESULTS: Out of 1586 PLWH who reported a unique partner at enrollment, 171 had a previously enrolled partner, leaving 1415 (89%) IC. HIV status of the partner was reported as unknown in 571 (40%), seronegative in 325 (23%) and seropositive in 519 (37%). Out of 896 partners in the unknown/seronegative group, 72 (8%) had HIV testing, 42/72 (58%) tested within three months of IC enrollment. Among the 49/72 (68%) who tested positive for HIV, 33 (67%) were enrolled in the HIV program. The proportion in WHO clinical stage IV was lower in enrolled partners compared to IC (37% vs 9%, p = 0.04). Non-tested partners (824) were likely reachable by the hospital, as 297/824 (36%) of their IC were admitted in the study center at least once, 51/243 (21%) female IC had received pregnancy care at the study center, and 401/692 (64%) of IC on antiretroviral therapy had achieved viral suppression, implying frequent visits to the hospital for pill pick-up. CONCLUSION: In this setting, HIV testing of partners of PLWH was suboptimal, illustrating missed opportunities for HIV control. Integration of HIV strategies in primarily clinical-oriented services is a challenging need.


Assuntos
Infecções por HIV/diagnóstico , Infecções por HIV/prevenção & controle , Programas de Rastreamento , Parceiros Sexuais , Adulto , Feminino , Soronegatividade para HIV , Humanos , Masculino , Peru
9.
Rev. peru. med. exp. salud publica ; 38(1): 153-158, ene-mar 2021. tab
Artigo em Espanhol | LILACS | ID: biblio-1280590

RESUMO

RESUMEN Los adolescentes que viven con el VIH (AVVIH) tienen tasas más bajas de supresión virológica y tasas más altas de deterioro inmunológico en comparación con sus contrapartes mayores, colocándolos potencialmente en alto riesgo de enfermedad severa por SARS-CoV-2. Los AVVIH que están transicionando hacia el cuidado de adultos enfrentan dificultades adicionales para permanecer en el cuidado y adherirse al tratamiento antirretroviral. En esta sección especial reportamos el impacto observado en AVVIH transicionando al servicio de VIH para adultos durante la pandemia por SARS-CoV-2. En primer lugar, el acceso a la atención del VIH se ha visto perjudicado por la restricción del transporte público, la falta de antirretrovirales, y la suspensión de citas médicas y laboratoriales. Adicionalmente, dificultades financieras, incertidumbre sobre el futuro, estresores emocionales, alteración del estilo de vida y el temor de divulgar el diagnóstico involuntariamente han desafiado aún más la continuidad en la atención de esta población adolescente.


ABSTRACT Adolescents living with HIV (ALWH) have lower rates of virologic suppression and higher rates of immunologic decline compared to their older counterparts, potentially placing them at high-risk for developing severe SARS-CoV-2 disease. ALWH who are transitioning to adult care face additional challenges to remaining in care and adhering to treatment. In this special section we report the experiences of ALWH in the process of transitioning to adult HIV services during the COVID-19 pandemic. In first place, the government-mandated stay-at-home order has substantially limited access to full HIV care by restricting public transportation, HIV medication stock-outs, and the suspension of routine medical and laboratory appointments. In addition, financial hardship, uncertainty about their future plans, emotional stressors, lifestyle disruptions, and concerns of involuntary disclosure have further challenged continuity in care for this adolescent population.


Assuntos
Humanos , Masculino , Feminino , Adolescente , HIV , Pandemias , SARS-CoV-2 , Peru , População , Saúde Mental , Impactos da Poluição na Saúde , Acessibilidade aos Serviços de Saúde
10.
Rev. peru. med. exp. salud publica ; 38(1): 153-158, ene-mar 2021. tab
Artigo em Espanhol | LILACS | ID: biblio-1280561

RESUMO

RESUMEN Los adolescentes que viven con el VIH (AVVIH) tienen tasas más bajas de supresión virológica y tasas más altas de deterioro inmunológico en comparación con sus contrapartes mayores, colocándolos potencialmente en alto riesgo de enfermedad severa por SARS-CoV-2. Los AVVIH que están transicionando hacia el cuidado de adultos enfrentan dificultades adicionales para permanecer en el cuidado y adherirse al tratamiento antirretroviral. En esta sección especial reportamos el impacto observado en AVVIH transicionando al servicio de VIH para adultos durante la pandemia por SARS-CoV-2. En primer lugar, el acceso a la atención del VIH se ha visto perjudicado por la restricción del transporte público, la falta de antirretrovirales, y la suspensión de citas médicas y laboratoriales. Adicionalmente, dificultades financieras, incertidumbre sobre el futuro, estresores emocionales, alteración del estilo de vida y el temor de divulgar el diagnóstico involuntariamente han desafiado aún más la continuidad en la atención de esta población adolescente.


ABSTRACT Adolescents living with HIV (ALWH) have lower rates of virologic suppression and higher rates of immunologic decline compared to their older counterparts, potentially placing them at high-risk for developing severe SARS-CoV-2 disease. ALWH who are transitioning to adult care face additional challenges to remaining in care and adhering to treatment. In this special section we report the experiences of ALWH in the process of transitioning to adult HIV services during the COVID-19 pandemic. In first place, the government-mandated stay-at-home order has substantially limited access to full HIV care by restricting public transportation, HIV medication stock-outs, and the suspension of routine medical and laboratory appointments. In addition, financial hardship, uncertainty about their future plans, emotional stressors, lifestyle disruptions, and concerns of involuntary disclosure have further challenged continuity in care for this adolescent population.


Assuntos
Humanos , Masculino , Feminino , Peru , Adolescente , HIV , SARS-CoV-2 , Saúde Mental , Impactos da Poluição na Saúde , COVID-19 , Acessibilidade aos Serviços de Saúde
11.
PLoS Negl Trop Dis ; 9(11): e0004197, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26523733

RESUMO

In developing countries, education to health-care professionals is a cornerstone in the battle against neglected tropical diseases (NTD). Studies evaluating the level of knowledge of medical students in clinical and socio-demographic aspects of NTD are lacking. Therefore, a cross-sectional study was conducted among students from a 7 year-curriculum medical school in Peru to assess their knowledge of NTD by using a pilot survey comprised by two blocks of 10 short questions. Block I consisted of socio-demographic and epidemiological questions whereas block II included clinical vignettes. Each correct answer had the value of 1 point. Out of 597 responders (response rate: 68.4%), 583 were considered to have valid surveys (male:female ratio: 1:1.01; mean age 21 years, SD ± 2.42). Total knowledge showed a raising trend through the 7-year curriculum. Clinical knowledge seemed to improve towards the end of medical school whereas socio-demographic and epidemiological concepts only showed progress the first 4 years of medical school, remaining static for the rest of the curricular years (p = 0.66). Higher mean scores in socio-demographic and epidemiological knowledge compared to clinical knowledge were seen in the first two years (p<0.001) whereas the last three years showed higher scores in clinical knowledge (p<0.001). In conclusion, students from this private medical school gained substantial knowledge in NTD throughout the career which seems to be related to improvement in clinical knowledge rather than to socio-demographic and epidemiological concepts. This study assures the feasibility of measuring the level of knowledge of NTD in medical students and stresses the importance of evaluating education on NTD as it may need more emphasis in epidemiological concepts, especially at developing countries such as Peru where many people are affected by these preventable and treatable diseases.


Assuntos
Doenças Transmissíveis/epidemiologia , Doenças Transmissíveis/patologia , Doenças Negligenciadas/epidemiologia , Doenças Negligenciadas/patologia , Competência Profissional , Estudantes de Medicina , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Peru , Inquéritos e Questionários , Clima Tropical , Adulto Jovem
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