Effect of Ultralight Dark Matter on g-2 of the Electron.

If dark matter is ultralight, the number density of dark matter is very high, and the techniques of zero-temperature field theory are no longer valid. The dark matter number density modifies the vacuum, giving it a non-negligible particle occupation number. For fermionic dark matter, this occupation number can be no larger than one. However, in the case of bosons, the occupation number is unbounded. If there is a large occupation number, the Bose enhancement needs to be taken into consideration for any process involving particles which interact with the dark matter. Because the occupation number scales inversely with the dark matter mass, this effect is most prominent for ultralight dark matter. In fact, the Bose enhancement effect from the background is so significant for ultralight dark matter that, if dark matter is a dark photon, the correction to the anomalous magnetic moment is larger than experimental uncertainties for a mixing parameter of the order of 10^{-16} and a dark photon mass of the order of 10^{-20} eV. Furthermore, the constraint on the mixing parameter scales linearly with the dark photon mass, and so new significant constraints can be placed on the dark matter mass all the way up to 10^{-14} eV. Future experiments measuring g-2 will probe even smaller gauge mixing parameters.

Australia's Tinderbox Drought: An extreme natural event likely worsened by human-caused climate change.

We examine the characteristics and causes of southeast Australia's Tinderbox Drought (2017 to 2019) that preceded the Black Summer fire disaster. The Tinderbox Drought was characterized by cool season rainfall deficits of around -50% in three consecutive years, which was exceptionally unlikely in the context of natural variability alone. The precipitation deficits were initiated and sustained by an anomalous atmospheric circulation that diverted oceanic moisture away from the region, despite traditional indicators of drought risk in southeast Australia generally being in neutral states. Moisture deficits were intensified by unusually high temperatures, high vapor pressure deficits, and sustained reductions in terrestrial water availability. Anthropogenic forcing intensified the rainfall deficits of the Tinderbox Drought by around 18% with an interquartile range of 34.9 to -13.3% highlighting the considerable uncertainty in attributing droughts of this kind to human activity. Skillful predictability of this drought was possible by incorporating multiple remote and local predictors through machine learning, providing prospects for improving forecasting of droughts.

KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma.

Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. Here, we screen 62,643 compounds using an engineered cell line that monitors PAX3-FOXO1 transcriptional activity identifying a hitherto uncharacterized compound, P3FI-63. RNA-seq, ATAC-seq, and docking analyses implicate histone lysine demethylases (KDMs) as its targets. Enzymatic assays confirm the inhibition of multiple KDMs with the highest selectivity for KDM3B. Structural similarity search of P3FI-63 identifies P3FI-90 with improved solubility and potency. Biophysical binding of P3FI-90 to KDM3B is demonstrated using NMR and SPR. P3FI-90 suppresses the growth of FP-RMS in vitro and in vivo through downregulating PAX3-FOXO1 activity, and combined knockdown of KDM3B and KDM1A phenocopies P3FI-90 effects. Thus, we report KDM inhibitors P3FI-63 and P3FI-90 with the highest specificity for KDM3B. Their potent suppression of PAX3-FOXO1 activity indicates a possible therapeutic approach for FP-RMS and other transcriptionally addicted cancers.