Detalhe da pesquisa
1.
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.
Nat Immunol;
16(6): 642-52, 2015 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25915733
2.
Pharmaceutical SH2 domain-containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity.
Hepatology;
77(5): 1512-1526, 2023 05 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35503714
3.
Enhancing the therapeutic efficacy of programmed death ligand 1 antibody for metastasized liver cancer by overcoming hepatic immunotolerance in mice.
Hepatology;
76(3): 630-645, 2022 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34860431
4.
Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies.
Hepatology;
73 Suppl 1: 104-114, 2021 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32715491
5.
Lens differentiation is controlled by the balance between PDGF and FGF signaling.
PLoS Biol;
17(2): e3000133, 2019 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30716082
6.
A tumorigenic index for quantitative analysis of liver cancer initiation and progression.
Proc Natl Acad Sci U S A;
116(52): 26873-26880, 2019 Dec 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31843886
7.
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels.
J Biol Chem;
295(31): 10842-10856, 2020 07 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32546483
8.
An Efficient Combination Immunotherapy for Primary Liver Cancer by Harmonized Activation of Innate and Adaptive Immunity in Mice.
Hepatology;
69(6): 2518-2532, 2019 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30693544
9.
Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury.
Hepatology;
69(5): 2196-2213, 2019 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30520052
10.
Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis.
PLoS Genet;
13(10): e1007047, 2017 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29028795
11.
Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase.
Proc Natl Acad Sci U S A;
114(18): 4816-4821, 2017 05 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28424251
12.
A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.
Genes Dev;
26(14): 1587-601, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22759635
13.
High-fat feeding reprograms maternal energy metabolism and induces long-term postpartum obesity in mice.
Int J Obes (Lond);
43(9): 1747-1758, 2019 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30622311
14.
ß-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic ß-catenin and MET.
Hepatology;
67(5): 1807-1822, 2018 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29152756
15.
Stress Conditions Induced by Locoregional Therapies Stimulate Enrichment and Proliferation of Liver Cancer Stem Cells.
J Vasc Interv Radiol;
30(12): 2016-2025.e5, 2019 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31208945
16.
Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.
Proc Natl Acad Sci U S A;
113(46): 13156-13161, 2016 11 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27799550
17.
Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting.
Proc Natl Acad Sci U S A;
113(8): 2206-11, 2016 Feb 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26858399
18.
Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic ß-Catenin, PIK3CA and MET.
J Hepatol;
69(1): 79-88, 2018 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29505847
19.
Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways.
FASEB J;
31(12): 5530-5542, 2017 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28842424
20.
Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals.
Proc Natl Acad Sci U S A;
112(43): 13342-7, 2015 Oct 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26460004