Detalhe da pesquisa
1.
Genetic toxicology in silico protocol.
Regul Toxicol Pharmacol;
107: 104403, 2019 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31195068
2.
In silico toxicology protocols.
Regul Toxicol Pharmacol;
96: 1-17, 2018 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29678766
3.
Comparative evaluation of 11 in silico models for the prediction of small molecule mutagenicity: role of steric hindrance and electron-withdrawing groups.
Toxicol Mech Methods;
27(1): 24-35, 2017 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27813437
4.
Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity.
Regul Toxicol Pharmacol;
77: 1-12, 2016 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26879463
5.
Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses.
Regul Toxicol Pharmacol;
77: 13-24, 2016 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26877192
6.
Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: comparative analysis, molecular docking, bioactivation and toxicological implications.
Drug Metab Rev;
47(3): 291-319, 2015 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26024250
7.
Mechanistic studies of the cationic binding pocket of CYP2C9 in vitro and in silico: metabolism of nonionizable analogs of tienilic acid.
Drug Metab Dispos;
42(11): 1955-63, 2014 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25187484
8.
1-Aminobenzotriazole coincubated with (S)-warfarin results in potent inactivation of CYP2C9.
Drug Metab Dispos;
42(5): 813-7, 2014 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24550229
9.
Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.
Toxicol Appl Pharmacol;
266(1): 86-94, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23142475
10.
Role of electrostatic potential in the in silico prediction of molecular bioactivation and mutagenesis.
Mol Pharm;
10(4): 1171-82, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23323940
11.
Elucidation of the mechanism of ribose conjugation in a pyrazole-containing compound in rodent liver.
Xenobiotica;
43(3): 236-45, 2013 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22931212
12.
Neonicotinoid insecticides induce salicylate-associated plant defense responses.
Proc Natl Acad Sci U S A;
107(41): 17527-32, 2010 Oct 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20876120
13.
Characterization of rat liver proteins adducted by reactive metabolites of menthofuran.
Chem Res Toxicol;
25(11): 2301-9, 2012 Nov 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23106769
14.
Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.
Chem Res Toxicol;
24(10): 1668-77, 2011 Oct 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21905702
15.
Refinement, Reduction, and Replacement of Animal Toxicity Tests by Computational Methods.
ILAR J;
57(2): 226-233, 2016 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28053075
16.
Chemoselective sp2-sp3 cross-couplings: iron-catalyzed alkyl transfer to dihaloaromatics.
Org Lett;
15(14): 3698-701, 2013 Jul 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23829418
17.
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
J Agric Food Chem;
59(9): 4860-7, 2011 May 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21476569
18.
Enzymes and inhibitors in neonicotinoid insecticide metabolism.
J Agric Food Chem;
57(11): 4861-6, 2009 Jun 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19391582
19.
Comparative metabolism and pharmacokinetics of seven neonicotinoid insecticides in spinach.
J Agric Food Chem;
56(21): 10168-75, 2008 Nov 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18922014
20.
Unique and common metabolites of thiamethoxam, clothianidin, and dinotefuran in mice.
Chem Res Toxicol;
19(11): 1549-56, 2006 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17112244