Detalhe da pesquisa
1.
Identification of truncated C-terminal fragments of the Alzheimer's disease amyloid protein precursor derived from sequential proteolytic pathways.
J Neurochem;
156(6): 943-956, 2021 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32757390
2.
The metalloprotease ADAMTS4 generates N-truncated Aß4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Acta Neuropathol;
137(2): 239-257, 2019 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30426203
3.
Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-ß Peptide Production.
J Biol Chem;
292(9): 3751-3767, 2017 03 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28096459
4.
Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells.
FASEB J;
31(4): 1382-1397, 2017 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28034848
5.
The adipocyte differentiation protein APMAP is an endogenous suppressor of Aß production in the brain.
Hum Mol Genet;
24(2): 371-82, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25180020
6.
The lipidome associated with the γ-secretase complex is required for its integrity and activity.
Biochem J;
473(3): 321-34, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26811537
7.
Perturbations of the straight transmembrane α-helical structure of the amyloid precursor protein affect its processing by γ-secretase.
J Biol Chem;
289(10): 6763-6774, 2014 Mar 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24469457
8.
Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase.
Biochim Biophys Acta;
1842(12 Pt A): 2500-9, 2014 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25315299
9.
Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aß production.
J Neurochem;
133(3): 409-21, 2015 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25458374
10.
Novel therapeutic strategy for neurodegeneration by blocking Aß seeding mediated aggregation in models of Alzheimer's disease.
Neurobiol Dis;
74: 144-57, 2015 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25173807
11.
Production of active glycosylation-deficient γ-secretase complex for crystallization studies.
Biotechnol Bioeng;
112(12): 2516-26, 2015 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26059427
12.
The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-ß generation.
J Biol Chem;
288(4): 2521-31, 2013 Jan 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23209290
13.
Substrate-targeting gamma-secretase modulators.
Nature;
453(7197): 925-9, 2008 Jun 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18548070
14.
Label-free imaging of cerebral ß-amyloidosis with extended-focus optical coherence microscopy.
J Neurosci;
32(42): 14548-56, 2012 Oct 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23077040
15.
Highly efficient production of the Alzheimer's γ-secretase integral membrane protease complex by a multi-gene stable integration approach.
Biotechnol Bioeng;
110(7): 1995-2005, 2013 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23359429
16.
A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aß synaptotoxicity.
Cell Death Discov;
9(1): 444, 2023 Dec 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38062019
17.
Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies.
Biochemistry;
51(44): 8779-90, 2012 Nov 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23066899
18.
Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases.
J Biol Chem;
286(4): 2762-73, 2011 Jan 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21084300
19.
Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila.
FASEB J;
25(7): 2287-95, 2011 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21415381
20.
Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.
FASEB J;
24(7): 2464-74, 2010 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20237298