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1.
Phys Rev Lett ; 131(7): 077201, 2023 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-37656840

RESUMO

We consider a system of linear oscillators, or quantum states, described by random matrix theory and analyze how its time evolution is affected by a nonlinear perturbation. Our numerical results show that above a certain chaos border a weak or moderate nonlinearity leads to a dynamical thermalization of a finite number of degrees of freedom with energy equipartition over linear eigenmodes as expected from the laws of classical statistical mechanics. The system temperature is shown to change in a broad range from positive to negative values, and the dependence of system characteristics on the initial injected energy is determined. Below the chaos border the dynamics is described by the Kolmogorov-Arnold-Moser integrability. Owing to universal features of random matrix theory we argue that the obtained results describe the generic properties of its nonlinear perturbation.

2.
PLoS Comput Biol ; 16(2): e1007652, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-32069277

RESUMO

English Wikipedia, containing more than five millions articles, has approximately eleven thousands web pages devoted to proteins or genes most of which were generated by the Gene Wiki project. These pages contain information about interactions between proteins and their functional relationships. At the same time, they are interconnected with other Wikipedia pages describing biological functions, diseases, drugs and other topics curated by independent, not coordinated collective efforts. Therefore, Wikipedia contains a directed network of protein functional relations or physical interactions embedded into the global network of the encyclopedia terms, which defines hidden (indirect) functional proximity between proteins. We applied the recently developed reduced Google Matrix (REGOMAX) algorithm in order to extract the network of hidden functional connections between proteins in Wikipedia. In this network we discovered tight communities which reflect areas of interest in molecular biology or medicine and can be considered as definitions of biological functions shaped by collective intelligence. Moreover, by comparing two snapshots of Wikipedia graph (from years 2013 and 2017), we studied the evolution of the network of direct and hidden protein connections. We concluded that the hidden connections are more dynamic compared to the direct ones and that the size of the hidden interaction communities grows with time. We recapitulate the results of Wikipedia protein community analysis and annotation in the form of an interactive online map, which can serve as a portal to the Gene Wiki project.


Assuntos
Fenômenos Biológicos , Biologia Computacional/métodos , Mapeamento de Interação de Proteínas , Proteínas/química , Ferramenta de Busca , Algoritmos , Análise por Conglomerados , Bases de Dados Genéticas , Internet , Cadeias de Markov , Probabilidade
3.
Int J Mol Sci ; 23(1)2021 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-35008491

RESUMO

Protein-protein interactions is a longstanding challenge in cardiac remodeling processes and heart failure. Here, we use the MetaCore network and the Google matrix algorithms for prediction of protein-protein interactions dictating cardiac fibrosis, a primary cause of end-stage heart failure. The developed algorithms allow identification of interactions between key proteins and predict new actors orchestrating fibroblast activation linked to fibrosis in mouse and human tissues. These data hold great promise for uncovering new therapeutic targets to limit myocardial fibrosis.


Assuntos
Fibrose/metabolismo , Mapas de Interação de Proteínas/fisiologia , Algoritmos , Animais , Insuficiência Cardíaca/metabolismo , Humanos , Camundongos , Miocárdio/metabolismo , Ferramenta de Busca/métodos , Remodelação Ventricular/fisiologia
4.
Phys Rev E ; 109(4-1): 044201, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38755800

RESUMO

We introduce and study a random matrix model of Kolmogorov-Zakharov turbulence in a nonlinear purely dynamical finite-size system with many degrees of freedom. For the case of a direct cascade, the energy and norm pumping takes place at low energy scales with absorption at high energies. For a pumping strength above a certain chaos border, a global chaotic attractor appears with a stationary energy flow through a Hamiltonian inertial energy interval. In this regime, the steady-state norm distribution is described by an algebraic decay with an exponent in agreement with the Kolmogorov-Zakharov theory. Below the chaos border, the system is located in the quasi-integrable regime similar to the Kolmogorov-Arnold-Moser theory and the turbulence is suppressed. For the inverse cascade, the system rapidly enters a strongly nonlinear regime where the weak turbulence description is invalid. We argue that such a dynamical turbulence is generic, showing that it is present in other lattice models with disorder and Anderson localization. We point out that such dynamical models can be realized in multimode optical fibers.

5.
Phys Rev E ; 108(5-1): 054212, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-38115518

RESUMO

We consider a model of an intelligent surfer moving on the Ulam network generated by a chaotic dynamics in the Chirikov standard map. This directed network is obtained by the Ulam method with a division of the phase space in cells of fixed size forming the nodes of a Markov chain. The goal quest for this surfer is to determine the network path from an initial node A to a final node B with minimal resistance given by the sum of inverse transition probabilities. We develop an algorithm for the intelligent surfer that allows us to perform the quest in a small number of transitions which grows only logarithmically with the network size. The optimal path search is done on a fractal intersection set formed by nodes with small Erdös numbers of the forward and inverted networks. The intelligent surfer exponentially outperforms a naive surfer who tries to minimize its phase space distance to target B. We argue that such an algorithm provides unique hints for motion control in chaotic flows.

6.
Phys Rev E Stat Nonlin Soft Matter Phys ; 80(1 Pt 2): 016210, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19658795

RESUMO

We consider the classical and quantum properties of the "Chirikov typical map," proposed by Boris Chirikov in 1969. This map is obtained from the well-known Chirikov standard map by introducing a finite-number T of random phase-shift angles. These angles induce a random behavior for small time-scales (tT) . We identify the classical chaos border k(c) approximately T (-3/2)1 for the kick parameter k and two regimes with diffusive behavior on short and long time scales. The quantum dynamics is characterized by the effect of Chirikov localization (or dynamical localization). We find that the localization length depends in a subtle way on the two classical diffusion constants in the two time-scale regime.

7.
Artigo em Inglês | MEDLINE | ID: mdl-25353851

RESUMO

We study the statistical properties of spectrum and eigenstates of the Google matrix of the citation network of Physical Review for the period 1893-2009. The main fraction of complex eigenvalues with largest modulus is determined numerically by different methods based on high-precision computations with up to p = 16384 binary digits that allow us to resolve hard numerical problems for small eigenvalues. The nearly nilpotent matrix structure allows us to obtain a semianalytical computation of eigenvalues. We find that the spectrum is characterized by the fractal Weyl law with a fractal dimension d(f) ≈ 1. It is found that the majority of eigenvectors are located in a localized phase. The statistical distribution of articles in the PageRank-CheiRank plane is established providing a better understanding of information flows on the network. The concept of ImpactRank is proposed to determine an influence domain of a given article. We also discuss the properties of random matrix models of Perron-Frobenius operators.

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