Detalhe da pesquisa
1.
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
Bioorg Med Chem Lett;
30(17): 127390, 2020 09 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32738973
2.
Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery.
J Chem Inf Model;
60(9): 4144-4152, 2020 09 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32309939
3.
Performance of multiple docking and refinement methods in the pose prediction D3R prospective Grand Challenge 2016.
J Comput Aided Mol Des;
32(1): 113-127, 2018 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28913710
4.
Workflows and performances in the ranking prediction of 2016 D3R Grand Challenge 2: lessons learned from a collaborative effort.
J Comput Aided Mol Des;
32(1): 129-142, 2018 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28986733
5.
Discovery of novel BTK inhibitors with carboxylic acids.
Bioorg Med Chem Lett;
27(6): 1471-1477, 2017 03 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28254166
6.
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis.
Bioorg Med Chem Lett;
27(16): 3939-3943, 2017 08 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28720503
7.
The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors.
Bioorg Med Chem Lett;
26(11): 2622-6, 2016 06 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27106708
8.
Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.
Bioorg Med Chem Lett;
25(24): 5767-71, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26546218
9.
Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected].
Bioorg Med Chem Lett;
23(19): 5361-6, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23972441
10.
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization.
Bioorg Med Chem;
20(9): 2845-9, 2012 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22494842
11.
Drug-like density: a method of quantifying the "bindability" of a protein target based on a very large set of pockets and drug-like ligands from the Protein Data Bank.
J Chem Inf Model;
50(11): 2029-40, 2010 Nov 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20977231
12.
Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.
Bioorg Med Chem Lett;
19(6): 1564-8, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19243937
13.
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.
Bioorg Med Chem Lett;
19(18): 5334-8, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19683443
14.
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.
Bioorg Med Chem Lett;
19(18): 5329-33, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19674896
15.
Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.
Bioorg Med Chem Lett;
18(13): 3706-10, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18524582
16.
A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice.
Endocrinol Diabetes Metab;
1(1): e00002, 2018 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30815539
17.
Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.
ACS Med Chem Lett;
7(5): 498-501, 2016 May 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27190600
18.
Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.
ACS Med Chem Lett;
7(2): 198-203, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26985298
19.
Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels.
Proteins;
52(2): 146-54, 2003 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12833539
20.
Glycine 30 in iberiotoxin is a critical determinant of its specificity for maxi-K versus K(V) channels.
FEBS Lett;
527(1-3): 298-302, 2002 Sep 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12220678