Detalhe da pesquisa
1.
Programming inactive RNA-binding small molecules into bioactive degraders.
Nature;
618(7963): 169-179, 2023 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37225982
2.
Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera.
Proc Natl Acad Sci U S A;
121(2): e2306682120, 2024 Jan 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38181056
3.
A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome.
Proc Natl Acad Sci U S A;
119(48): e2210532119, 2022 11 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36409902
4.
Low-Molecular Weight Small Molecules Can Potently Bind RNA and Affect Oncogenic Pathways in Cells.
J Am Chem Soc;
144(45): 20815-20824, 2022 11 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36322830
5.
Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion.
J Am Chem Soc;
144(48): 21972-21979, 2022 12 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36399603
6.
Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA.
J Am Chem Soc;
144(26): 11620-11625, 2022 07 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35737519
7.
Correction to "Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA".
J Am Chem Soc;
145(16): 9364, 2023 Apr 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37058601
8.
HIV-1 transcriptional modulation: novel host factors and prospective therapeutic strategies.
Curr Opin HIV AIDS;
18(5): 264-272, 2023 09 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37535041
9.
Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy.
ACS Cent Sci;
9(7): 1342-1353, 2023 Jul 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37521782
10.
Targeting RNA structures with small molecules.
Nat Rev Drug Discov;
21(10): 736-762, 2022 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35941229
11.
Local Phenomena Shape Backyard Soil Metabolite Composition.
Metabolites;
10(3)2020 Feb 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32121389