Detalhe da pesquisa
1.
Small-Molecule Agonists of Ae. aegypti Neuropeptide Y Receptor Block Mosquito Biting.
Cell;
176(4): 687-701.e5, 2019 02 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30735632
2.
Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.
PLoS Biol;
19(7): e3001355, 2021 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34319985
3.
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Proc Natl Acad Sci U S A;
116(24): 11946-11955, 2019 06 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31142647
4.
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.
Nat Chem Biol;
12(10): 838-44, 2016 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27547922
5.
Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.
J Biol Chem;
291(18): 9776-84, 2016 Apr 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26961873
6.
Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.
Nat Chem Biol;
9(4): 247-9, 2013 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23416332
7.
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.
Proc Natl Acad Sci U S A;
109(40): 16004-11, 2012 Oct 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23012453
8.
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055.
ACS Med Chem Lett;
15(4): 524-532, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38628784
9.
Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization.
Proc Natl Acad Sci U S A;
107(50): 21812-7, 2010 Dec 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21098282
10.
Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.
Cell Chem Biol;
30(11): 1366-1376.e7, 2023 11 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37536341
11.
High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease.
Mol Metab;
78: 101832, 2023 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38403978
12.
Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.
Nat Chem Biol;
6(9): 660-6, 2010 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20711197
13.
An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance.
Cell Chem Biol;
29(5): 854-869.e9, 2022 05 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34818532
14.
Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening.
Cancer Discov;
11(10): 2544-2563, 2021 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34127480
15.
Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-ß.
Cell Chem Biol;
26(7): 926-935.e6, 2019 07 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31031140
16.
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Nat Commun;
10(1): 2261, 2019 05 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31113940
17.
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Nat Commun;
10(1): 2691, 2019 06 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31217428
18.
Scintillation proximity assays in high-throughput screening.
Assay Drug Dev Technol;
6(3): 433-55, 2008 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18593378
19.
Farnesyl pyrophosphate synthase: real-time kinetics and inhibition by nitrogen-containing bisphosphonates in a scintillation assay.
Assay Drug Dev Technol;
5(2): 205-14, 2007 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17477829
20.
A High-Content Live-Cell Viability Assay and Its Validation on a Diverse 12K Compound Screen.
SLAS Discov;
22(9): 1120-1130, 2017 10 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28783477