RESUMO
Binder's syndrome is a rare congenital deformity characterized by midface hypoplasia, particularly around the nasomaxillary area. Genetic etiology or developmental failure caused by prenatal exposure to teratological agents has been considered. In this article, we present 3 related rhesus monkeys born with orofacial deformities similar to those found in infants with the Binder phenotype. For the first time, a primate biomodel for this condition is presented. The clinical description and association with management and environmental factors are discussed. These findings reinforce the knowledge about the relationship between possible vitamin K metabolism interference and Binder's syndrome.
Assuntos
Anormalidades Maxilofaciais , Nariz , Humanos , Lactente , Gravidez , Feminino , Animais , Nariz/anormalidades , Macaca mulatta , Maxila/anormalidadesRESUMO
Congenital digital defects, particularly adactyly and oligodactyly, have been reported frequently in humans, however, their occurrence in rhesus monkeys is rare, mainly in the hind limbs. We present here for the first time, two female rhesus monkeys with unilateral congenital toe defects with metatarsal involvement. One showing adactyly and the other oligodactyly. In this report, we present the clinical/radiological details of these cases as well as discuss the risk factors possibly involved, such as contact with pesticides and genetic factors.
Assuntos
Ossos do Metatarso , Humanos , Feminino , Animais , Macaca mulatta , Ossos do Metatarso/diagnóstico por imagemRESUMO
In a captive Macaca mulatta breeding colony, a single family group with 39 animals showed 19 individuals being born with dramatic tail shortening. Through clinical, genealogical, radiographic, and cytogenetic evaluation, it was related to a probable dominant autosomal inheritance of the reduction in the number of distal caudal vertebrae.
Assuntos
Macaca mulatta/anormalidades , Doenças dos Macacos/congênito , Cauda/anormalidades , Animais , Animais de Laboratório/anormalidades , Feminino , Masculino , Cauda/anatomia & histologiaRESUMO
Hypomelanosis of Ito is a rare neurocutaneous syndrome, characterized by streaks and swirls of hypopigmentation arranged in a Blaschkoid pattern. Other associated anomalies are observed. We report a case of a male cynomolgus monkey (Macaca fascicularis) who presented the characteristic of hypomelanosis of Ito with palmoplantar involvement and polythelia.
Assuntos
Hipopigmentação/veterinária , Macaca fascicularis , Doenças dos Macacos/fisiopatologia , Animais , Hipopigmentação/fisiopatologia , MasculinoRESUMO
Vitiligo affects a significant portion of human and animal populations. The disease causes irregular and multifocal progressive loss of fur, skin, and mucous membrane pigmentation due to the loss or absence of melanocytes. While etiopathogenesis is not completely understood, autoimmunity, environmental, and genetic factors are implicated We present a case report on a 16-y-old female rhesus macaque (Macaca mulatta ) with depigmented areas that are progressively increasing on the skin and coat and are distributed on the head and back. Histopathology revealed alterations compatible with vitiligo characterized by the absence of melanocytes in the epidermis and dermis. The clinical history and complementary exams support this diagnosis.
Assuntos
Vitiligo , Feminino , Humanos , Animais , Vitiligo/veterinária , Vitiligo/patologia , Macaca mulatta , Pele/patologia , Epiderme/patologia , Melanócitos/patologiaRESUMO
A spontaneous mammary gland ductal carcinoma was diagnosed in a 13-year-old female captive rhesus monkey (Macaca mulatta). The expression of argyrophilic nucleolar organizer regions (AgNORs) was studied to investigate the correlation between the histologic invasiveness and cell proliferation activity assay for predicting the biologic behavior of this tumor type. The results of this study show that the AgNOR size in tumor cells reflect the degree of malignancy when compared with the pattern of peripheral blood lymphocytes of the same individual. This is the first study showing a significant AgNOR feature of a malignant breast tumor in a rhesus monkey and it longs to provide additional diagnostic tool in tumor pathology.
Assuntos
Carcinoma Ductal/ultraestrutura , Neoplasias Mamárias Animais/ultraestrutura , Doenças dos Macacos/patologia , Região Organizadora do Nucléolo/ultraestrutura , Animais , Carcinoma Ductal/patologia , Carcinoma Ductal/veterinária , Feminino , Linfócitos/ultraestrutura , Macaca mulatta , Neoplasias Mamárias Animais/patologia , PrognósticoRESUMO
Os osteossarcomas são tumores ósseos malignos, com padrões histológicos diversificados e etiologia desconhecida. O diagnóstico pode ser baseado na história clínica, exame físico, exames de imagem e confirmado por histopatologia. A remoção cirúrgica é essencial, devendo ser complementado por quimioterapia e/ou radioterapia. Entre os modelos animais, o cão é o que possui apresentação clínica, biológica, complicações e resultados com maior semelhança ao osteossarcoma humano. Outras espécies animais menos acometidas, também têm sido usadas como modelo para aprofundar os conhecimentos sobre o desenvolvimento e tratamento destes tumores. O objetivo deste trabalho é fazer uma revisão sobre o assunto, estabelecendo um paralelo entre os modelos animais acometidos por esta neoplasia, descrevendo as abordagens clinicas e evolução nos protocolos de tratamentos.
RESUMO
A anemia é um estado clínico onde ocorre a redução dos níveis da hemoglobina total, ou seja, diminuição da contagem da hemoglobina e/ou dos eritrócitos no sangue periférico. A deficiência de ferro na dieta constitui um fator que contribui para o desenvolvimento da anemia, denominada anemia ferropênica. Este trabalho visou levantar informações acerca das possíveis causas da anemia ferropênica em primatas do Novo Mundo e, assim, auxiliar os profissionais que atuam na área de criação de símios do neotrópico. O levantamento bibliográfico revelou que uma dieta pobre em ferro, bem como a presença de hemoparasitos e lesões de um modo geral, são os fatores predisponentes mais relevantes para o estabelecimento da anemia em primatas do Novo Mundo. De posse dos dados levantados, será possível direcionar o manejo clínico dos referidos animais; verificar necessidade de suplementação alimentar na rotina da criação; aprimorar o manejo reprodutivo das fêmeas gestantes para a prevenção das patologias decorrentes da carência de ferro; formular um cardápio apropriado de modo a melhorar o aproveitamento das fontes férreas; e finalmente determinar possíveis hematozoários desencadeadores de anemia ferropriva em primatas, auxiliando na elaboração de protocolos experimentais. Desta forma, com o intuito de manter os níveis séricos de ferro para o gênero estudado dentro dos seus padrões de normalidade, torna-se imperioso implantar um programa de manejo sanitário preventivo.
RESUMO
Cleft lip (with or without cleft palate) has been documented in several species of nonhuman primates, which in general are susceptible at similar doses and stages of gestation to the same teratogens as humans. Cleft lip can be unilateral or bilateral, isolated, syndromic, familial, or genetic. Here we report the first case of syndromic cleft lip and palate in a male bare-eared squirrel monkey (Saimiri ustus). Associated with the orofacial clefts, the monkey manifested absence of bones, malformation of vertebrae L3, only 4 fingers in each hand, and shortening of tendons leading to inflection of the hands and fingers. Previous reports describing cleft lip and palate in other squirrel monkeys (Saimiri sciureus) in other breeding units have suggested consanguineous mating as a possible cause. Although the etiology in the case we present is unknown, we discuss factors associated with orofacial clefts in humans and various nonhuman primates.
Assuntos
Anormalidades Múltiplas/veterinária , Fenda Labial/veterinária , Fissura Palatina/veterinária , Doenças dos Macacos/patologia , Saimiri/anormalidades , Anormalidades Múltiplas/diagnóstico por imagem , Anormalidades Múltiplas/patologia , Animais , Fenda Labial/complicações , Fenda Labial/patologia , Fissura Palatina/complicações , Fissura Palatina/patologia , Masculino , Doenças dos Macacos/diagnóstico por imagem , Doenças dos Macacos/etiologia , RadiografiaRESUMO
Clitoromegaly in the neonatal period is an important morphologic sign that can be useful for sexual determination in aberrant cases. In rhesus monkeys, differentiation of the external genitalia occurs early during gestation (at 55 to 60 d) and is complete by approximately 80 d. Most of the critical steps in genital differentiation in primates occur prenatally. We sought to determine clitoral size in normal rhesus monkeys (Macaca mulatta) and possible effects of age and inheritance. Clitoral length was highly variable and had no relationship to fertility. Statistical evaluation revealed no association in the distribution of daughters with and without clitoris between mothers with and without clitoris. However, even when mated with several female monkeys, some male macaques produced primarily daughters without clitoris.
Assuntos
Clitóris/anatomia & histologia , Macaca mulatta/anatomia & histologia , Animais , Feminino , Fertilidade , Diferenciação SexualRESUMO
We used conventional chromosomal staining to describe the karyotype of the critically endangered Lear's macaw, Anodorhynchus leari Bonaparte 1856. A diploid number of 2n = 70 and a karyotype similar to that of its congener Anodorhynchus hyacinthinus suggests that chromosomal rearrangements were not the main evolutionary mechanism in the genus.
Assuntos
Animais , Aves/genética , Cromossomos , Cariotipagem , PsittaciformesRESUMO
Neotropical parrots are among the most threatened groups of birds in the world, and many species are facing extinction in a near future. At the same time, the taxonomic position of many species remains unclear. Karyotype analysis has been used to elucidate the phylogenetic status of many bird groups, also providing important information for both in situ and ex situ conservation plans. The objective of the present study was to describe for the first time the karyotypes of the endangered Hyacinth Macaw, Anodorhynchus hyacinthinus, and of the Hawk-headed Parrot, Deroptyus accipitrinus. A diploid number of 2n = 70 and a karyotype similar to the main pattern previously found for the genera Ara, Cyanopsitta, Aratinga, Propyrrhura, Pionites, Pionopsitta, Nandayus, and Guaruba were found for both species. These karyotype descriptions can be a starting point for the genetic monitoring of these two declining species