Hippocampal contributions to novel spatial learning are both age-related and age-invariant.

Older adults show declines in spatial memory, although the extent of these alterations is not uniform across the healthy older population. Here, we investigate the stability of neural representations for the same and different spatial environments in a sample of younger and older adults using high-resolution functional MRI of the medial temporal lobes. Older adults showed, on average, lower neural pattern similarity for retrieving the same environment and more variable neural patterns compared to young adults. We also found a positive association between spatial distance discrimination and the distinctiveness of neural patterns between environments. Our analyses suggested that one source for this association was the extent of informational connectivity to CA1 from other subfields, which was dependent on age, while another source was the fidelity of signals within CA1 itself, which was independent of age. Together, our findings suggest both age-dependent and independent neural contributions to spatial memory performance.

Impact of age and apolipoprotein E ε4 status on regional white matter hyperintensity volume and cognition in healthy aging.

OBJECTIVE: White matter hyperintensity (WMH) volume is a neuroimaging marker of lesion load related to small vessel disease that has been associated with cognitive aging and Alzheimer's disease (AD) risk. METHOD: The present study sought to examine whether regional WMH volume mediates the relationship between APOE ε4 status, a strong genetic risk factor for AD, and cognition and if this association is moderated by age group differences within a sample of 187 healthy older adults (APOE ε4 status [carrier/non-carrier] = 56/131). RESULTS: After we controlled for sex, education, and vascular risk factors, ANCOVA analyses revealed significant age group by APOE ε4 status interactions for right parietal and left temporal WMH volumes. Within the young-old group (50-69 years), ε4 carriers had greater right parietal and left temporal WMH volumes than non-carriers. However, in the old-old group (70-89 years), right parietal and left temporal WMH volumes were comparable across APOE ε4 groups. Further, within ε4 non-carriers, old-old adults had greater right parietal and left temporal WMH volumes than young-old adults, but there were no significant differences across age groups in ε4 carriers. Follow-up moderated mediation analyses revealed that, in the young-old, but not the old-old group, there were significant indirect effects of ε4 status on memory and executive functions through left temporal WMH volume. CONCLUSIONS: These findings suggest that, among healthy young-old adults, increased left temporal WMH volume, in the context of the ε4 allele, may represent an early marker of cognitive aging with the potential to lead to greater risk for AD.

Retrieving autobiographical memories in autobiographical contexts: are age-related differences in narrated episodic specificity present outside of the laboratory?

The Autobiographical Interview, a method for evaluating detailed memory of real-world events, reliably detects differences in episodic specificity at retrieval between young and older adults in the laboratory. Whether this age-associated reduction in episodic specificity for autobiographical event retrieval is present outside of the laboratory remains poorly understood. We used a videoconference format to administer the Autobiographical Interview to cognitively unimpaired older adults (N = 49, M = 69.5, SD = 5.94) and young adults (N = 54, M = 22.5, SD = 4.19) who were in their homes at the time of retrieval. Relative to young adults, older adults showed reduced episodic specificity in their home environment, as reflected by fewer episodic or "internal" details (t (101) = 3.23, p = 0.009) and more "external" details (i.e., semantic, language-based details) (t (101) = 3.60, p = 0.003). These findings, along with detail subtype profiles in the narratives, bolster the ecological validity of the Autobiographical Interview and add promise to the use of virtual cognitive testing to improve the accessibility, participant diversity, scalability, and ecological validity of memory research.

How ready is speech-to-text for psychological language research? Evaluating the validity of AI-generated English transcripts for analyzing free-spoken responses in younger and older adults.

For the longest time, the gold standard in preparing spoken language corpora for text analysis in psychology was using human transcription. However, such standard comes at extensive cost, and creates barriers to quantitative spoken language analysis that recent advances in speech-to-text technology could address. The current study quantifies the accuracy of AI-generated transcripts compared to human-corrected transcripts across younger (n = 100) and older (n = 92) adults and two spoken language tasks. Further, it evaluates the validity of Linguistic Inquiry and Word Count (LIWC)-features extracted from these two kinds of transcripts, as well as transcripts specifically prepared for LIWC analyses via tagging. We find that overall, AI-generated transcripts are highly accurate with a word error rate of 2.50% to 3.36%, albeit being slightly less accurate for younger compared to older adults. LIWC features extracted from either transcripts are highly correlated, while the tagging procedure significantly alters filler word categories. Based on these results, automatic speech-to-text appears to be ready for psychological language research when using spoken language tasks in relatively quiet environments, unless filler words are of interest to researchers.

Evidence of Impaired Remote Experience-near Semantic Memory in Medial Temporal Lobe Amnesia.

Neuropsychological research suggests that "experience-near" semantic memory, meaning knowledge attached to a spatiotemporal or event context, is commonly impaired in individuals who have medial temporal lobe amnesia. It is not known if this impairment extends to remotely acquired experience-near knowledge, which is a question relevant to understanding hippocampal/medial temporal lobe functioning. In the present study, we administered a novel semantic memory task designed to target knowledge associated with remote, "dormant" concepts, in addition to knowledge associated with active concepts, to four individuals with medial temporal lobe amnesia and eight matched controls. We found that the individuals with medial temporal lobe amnesia generated significantly fewer experience-near semantic memories for both remote concepts and active concepts. In comparison, the generation of abstract or "experience-far" knowledge was largely spared in the individuals with medial temporal lobe amnesia, regardless of whether the targets for retrieval were remote or active concepts. We interpret these findings as evidence that the medial temporal lobes may have a sustained role in the retrieval of semantic memories associated with spatiotemporal and event contexts, which are cognitive features often ascribed to episodic memory. These results align with recent theoretical models proposing that the hippocampus/medial temporal lobes support cognitive processes that are involved in, but not exclusive to, episodic memory.

The impact of context on pattern separation for objects among younger and older apolipoprotein ϵ4 carriers and noncarriers.

OBJECTIVE: On continuous recognition tasks, changing the context objects are embedded in impairs memory. Older adults are worse on pattern separation tasks requiring identification of similar objects compared to younger adults. However, how contexts impact pattern separation in aging is unclear. The apolipoprotein (APOE) ϵ4 allele may exacerbate possible age-related changes due to early, elevated neuropathology. The goal of this study is to determine how context and APOE status affect pattern separation among younger and older adults. METHOD: Older and younger ϵ4 carriers and noncarriers were given a continuous object recognition task. Participants indicated if objects on a Repeated White background, Repeated Scene, or a Novel Scene were old, similar, or new. The proportions of correct responses and the types of errors made were calculated. RESULTS: Novel scenes lowered recognition scores compared to all other contexts for everyone. Younger adults outperformed older adults on identifying similar objects. Older adults misidentified similar objects as old more than new, and the repeated scene exacerbated this error. APOE status interacted with scene and age such that in repeated scenes, younger carriers produced less false alarms, and this trend switched for older adults where carriers made more false alarms. CONCLUSIONS: Context impacted recognition memory in the same way for both age groups. Older adults underutilized details and over relied on holistic information during pattern separation compared to younger adults. The triple interaction in false alarms may indicate an even greater reliance on holistic information among older adults with increased risk for Alzheimer's disease.

Simulating the best and worst of times: the powers and perils of emotional simulation.

We are remarkably capable of simulating events that we have never experienced. These simulated events often paint an emotional picture to behold, such as the best and worst possible outcomes that we might face. This review synthesises dispersed literature exploring the role of emotion in simulation. Drawing from work that suggests that simulations can influence our preferences, decision-making, and prosociality, we argue for a critical role of emotion in informing the consequences of simulation. We further unpack burgeoning evidence suggesting that the effects of emotional simulation transcend the laboratory. We propose avenues by which emotional simulation may be harnessed for both personal and collective good in applied contexts. We conclude by offering important future directions.

Influence of regional white matter hyperintensity volume and apolipoprotein E ε4 status on hippocampal volume in healthy older adults.

While total white matter hyperintensity (WMH) volume on magnetic resonance imaging (MRI) has been associated with hippocampal atrophy, less is known about how the regional distribution of WMH volume may differentially affect the hippocampus in healthy aging. Additionally, apolipoprotein E (APOE) ε4 carriers may be at an increased risk for greater WMH volumes and hippocampal atrophy in aging. The present study sought to investigate whether regional WMH volume mediates the relationship between age and hippocampal volume and if this association is moderated by APOE ε4 status in a group of 190 cognitively healthy adults (APOE ε4 status [carrier/non-carrier] = 59/131), ages 50-89. Analyses revealed that temporal lobe WMH volume significantly mediated the relationship between age and average bilateral hippocampal volume, and this effect was moderated by APOE ε4 status (-0.020 (SE = 0.009), 95% CI, [-0.039, -0.003]). APOE ε4 carriers, but not non-carriers, showed negative indirect effects of age on hippocampal volume through temporal lobe WMH volume (APOE ε4 carriers: -0.016 (SE = 0.007), 95% CI, [-0.030, -0.003]; APOE ε4 non-carriers: .005 (SE = 0.006), 95% CI, [-0.006, 0.017]). These findings remained significant after additionally adjusting for sex, years of education, hypertension status and duration, cholesterol status, diabetes status, Body Mass Index, history of smoking, and the Wechsler Adult Intelligence Scale-IV Full Scale IQ. There were no significant moderated mediation effects for frontal, parietal, and occipital lobe WMH volumes, with or without covariates. Our findings indicate that in cognitively healthy older adults, elevated WMH volume regionally localized to the temporal lobes in APOE ε4 carriers is associated with reduced hippocampal volume, suggesting greater vulnerability to brain aging and the risk for Alzheimer's disease.

Autobiographical Memory Fluency Reductions in Cognitively Unimpaired Middle-Aged and Older Adults at Increased Risk for Alzheimer's Disease Dementia.

OBJECTIVE: Recent research has revealed that cognitively unimpaired older adults who are at higher risk for developing Alzheimer's disease (AD) dementia often exhibit subtle cognitive alterations in their neuropsychological profiles. Emerging evidence suggests that autobiographical memory, which is memory for personal events and knowledge, may be sensitive to early AD-related cognitive alterations. In the present study, we investigated whether the rapid generation of autobiographical memory category exemplars, a retrieval process that taxes the neural network that is vulnerable to early AD, is compromised in cognitively unimpaired middle-aged and older carriers of the e4 allele of the apolipoprotein E gene (APOE4), which increases risk for AD dementia. METHODS: In addition to standard neuropsychological tests, we administered a fluency task that requires generating exemplars for two types of autobiographical memory, namely episodic memories and personal semantics, to a group of cognitively unimpaired middle-aged and older adults (n = 45) enriched with APOE4 carriers (n = 20). RESULTS: While no APOE4 deficits were found on standard neuropsychological tests, episodic and personal semantic exemplar generation was reduced in the APOE4 group. DISCUSSION: Autobiographical memory aberrations associated with a higher risk for AD are evident in fluency and affect both episodic memory and personal semantics.

Searching for the past: Exploring the dynamics of direct and generative autobiographical memory reconstruction among young and cognitively normal older adults.

Episodic autobiographical memories (EAMs) can come to mind through two retrieval routes, one direct (i.e., an EAM is retrieved almost instantaneously) and the other generative (i.e., by using autobiographical/general knowledge to cue an EAM). It is well established that normal cognitive aging is associated with a reduction in the retrieval of EAMs, but the contributions of direct or generative reconstruction to the age-related shift toward general memories remain unknown. Prior studies also have not clarified whether similar cognitive mechanisms facilitate the ability to successfully reconstruct EAMs and elaborate them in event-specific detail. To address these gaps in knowledge, young and older participants were asked to reconstruct EAMs using a "think-aloud" paradigm and then describe in detail a subset of retrieved memories. An adapted scoring procedure was implemented to categorize memories accessed during reconstruction, and the Autobiographical Interview (AI) scoring procedure was utilized for elaboration scoring. Results indicated that in comparison with young adults, older adults not only engaged in direct retrieval less often than young adults but they also more often ended generative retrieval at general events instead of EAMs. The ability to elaborate EAMs with internal details was positively associated with the ability to use generative retrieval to reconstruct EAMs in both young and older adults, but there was no relationship between internal detail elaboration and direct retrieval in either age group. Taken together, these results indicate age-related differences in direct and generative retrieval contribute to overgeneral autobiographical memory and they support a connection between generative retrieval and elaboration.

The Phishing Email Suspicion Test (PEST) a lab-based task for evaluating the cognitive mechanisms of phishing detection.

Phishing emails constitute a major problem, linked to fraud and exploitation as well as subsequent negative health outcomes including depression and suicide. Because of their sheer volume, and because phishing emails are designed to deceive, purely technological solutions can only go so far, leaving human judgment as the last line of defense. However, because it is difficult to phish people in the lab, little is known about the cognitive and neural mechanisms underlying phishing susceptibility. There is therefore a critical need to develop an ecologically valid lab-based measure of phishing susceptibility that will allow evaluation of the cognitive mechanisms involved in phishing detection. Here we present such a measure based on a task, the Phishing Email Suspicion Test (PEST), and a cognitive model to quantify behavior. In PEST, participants rate a series of phishing and non-phishing emails according to their level of suspicion. By comparing suspicion scores for each email to its real-world efficacy, we find initial support for the ecological validity of PEST - phishing emails that were more effective in the real world were more effective at deceiving people in the lab. In the proposed computational model, we quantify behavior in terms of participants' overall level of suspicion of emails, their ability to distinguish phishing from non-phishing emails, and the extent to which emails from the recent past bias their current decision. Together, our task and model provide a framework for studying the cognitive neuroscience of phishing detection.

Emotion matters: The influence of valence on episodic future thinking in young and older adults.

In young adults, valence not only alters the degree to which future events are imagined in rich episodic detail, but also how memorable these events are later on. For older adults, how valence influences episodic detail generation while imagining future events, or recalling these details at another time, remains unclear. We investigated the effect of valence on the specificity and memorability of episodic future thinking (EFT) in young and older adults. Among young and older adults, negative EFT was accompanied by less episodic detail generation relative to positive and neutral EFT. A similar reduction in episodic specificity for negative EFT was found two days later when participants recalled their previously imagined events. Notably, while older adults generated less episodically specific future thoughts relative to young adults, age did not influence the effect of valence on episodic detail generation at imagination or recollection.

Beyond episodic remembering: elaborative retrieval of lifetime periods in young and older adults.

Relative to young adults, cognitively normal older adults commonly generate more semantic details and fewer episodic details in their descriptions of unique life events. It remains unclear whether this reflects a specific change to episodic memory or a broader alteration to autobiographical narration. To explore age differences across different types of autobiographical narration, we created a lifetime period narrative task that involves describing extended events. For comparison, participants also described unique life events. All autobiographical narratives were scored for episodic, semantic, and other detail generation. Relative to young adults, older adults generated more detailed narratives for remote and recent lifetime periods, which was driven by their increased retrieval of personal and general semantic details. Older adults also generated more semantic details for unique life event narratives, along with reduced episodic detail. More broadly, in both groups lifetime period narratives were largely based on semantic details, whereas episodic details were more prominent in the descriptions of unique life events. These findings indicate that the elevated generation of semantic details associated with normal cognitive aging is reflected in multiple types of autobiographical narration. We suggest that lifetime period narration is a spared aspect of autobiographical memory among older adults.

The impact of cardiovascular risk factors on cognition in Hispanics and non-Hispanic whites.

Among non-Hispanic whites, cardiovascular risk factors are associated with increased mortality and poorer cognition. Prevalence of cardiovascular risk factors among aging Hispanics is also high and Hispanics generally have poorer access to healthcare, yet they tend to have advantageous cardiovascular disease rates and outcomes and live longer than non-Hispanic whites, an epidemiological phenomenon commonly referred to as the Hispanic or Latino health paradox. Although robust data support these ethnic benefits on physical health and mortality, it is unknown if it extends to include cognition resilience advantages in older adulthood. The present study compared relationships between cardiovascular risk and cognition (executive functions and episodic memory) in late middle age and older Hispanics (n = 87) and non-Hispanic whites (n = 81). Participants were selected from the National Alzheimer's Coordinating Center and Alzheimer's Disease Neuroimaging Initiative databases. Hispanics and non-Hispanic white groups were matched on age (50-94 yr, mean age = 72 yr), education, gender, cognitive status (i.e., cognitively healthy versus mildly cognitively impaired), and apolipoprotein E4 status. History of hypertension and higher body mass index were both associated with poorer executive functions among Hispanics but not non-Hispanic whites. Our findings suggest greater vulnerability to impairments in executive functions among Hispanics with hypertension and obesity, contrary to the notion of a Hispanic health paradox for cognitive aging.

Evidence that an episodic mode of thinking facilitates encoding of perceptually rich memories for naturalistic events relative to a gist-based mode of thinking.

Several studies have demonstrated that an episodic specificity induction (ESI) can influence cognitive abilities that involve episodic processes at retrieval. To better understand the downstream implications of an "episodic mode of thinking," we investigate whether an ESI influences encoding of new events. In a between-subjects design, participants were given an ESI or gist (control) induction. In an ostensibly unrelated task, participants then were shown film clips of naturalistic events. After a filled delay, participants were given a surprise memory test, which required narrative recollection of the film clips. Participants who received the ESI generated narratives that contained more perceptual details specifically. Relative to gist thinking, an episodic mode of thinking appears to facilitate encoding of perceptually rich memories for naturalistic events.

Self-Reference enhances memory for multi-element events judged likely to happen in young and older adults.

We investigated whether the strategy of self-reference can benefit memory for multi-element events, a kind of relational memory that is relatively less studied but highly relevant to daily life. Young and older adults imagined different person-object-location events with reference to themselves and two famous others (i.e., George Clooney and Oprah Winfrey), rated the likelihood that each event would happen, and then completed incidental memory tests on different pairs of elements within the event. We found that self-reference enhanced memory for object-location and person-object pairs in both age groups. Such self-reference effects were observed consistently only for events rated as likely to happen. There was also an overall memory advantage for the higher-likelihood events, which did not differ between young and older adults. Further, the self-reference effects were not correlated with memory functioning in either age group. Retrieval of within-event associations showed a significant level of dependency, which did not differ as a function of reference condition or likelihood category. These findings highlight the ways in which self-reference and prior knowledge improve relational memory, and suggest that the advantage of self-reference is not attributable to increased dependence of elements within complex events.

Evidence for Reduced Autobiographical Memory Episodic Specificity in Cognitively Normal Middle-Aged and Older Individuals at Increased Risk for Alzheimer's Disease Dementia.

OBJECTIVES: Alzheimer's disease (AD) typically eludes clinical detection for years, if not decades. The identification of subtle cognitive decline associated with preclinical AD would not only advance understanding of the disease, but also provide clinical targets to assess preventative and early intervention treatments. Disrupted retrieval of detailed episodic autobiographical memories may be a sensitive indicator of subtle cognitive decline, because this type of memory taxes a core neural network affected by preclinical AD neuropathology. METHODS: To begin to address this idea, we assessed the episodic specificity of autobiographical memories retrieved by cognitively normal middle-aged and older individuals who are carriers of the apolipoprotein E ε4 allele - a population at increased risk for subtle cognitive decline related to neuropathological risk factors for AD. We compared the ε4 carriers to non-carriers of ε4 similar in age, education, and gender. RESULTS: The ε4 carriers did not perform worse than the non-carriers on a comprehensive battery of neuropsychological tests. In contrast, as a group, the ε4 carriers generated autobiographical memories that were reduced in "internal" or episodic details relative to non-carriers. CONCLUSIONS: These findings support the notion that reduced autobiographical episodic detail generation may be a marker of subtle cognitive decline associated with AD. (JINS, 2018, 24, 1073-1183).

The association of personal semantic memory to identity representations: insight into higher-order networks of autobiographical contents.

Identity representations are higher-order knowledge structures that organise autobiographical memories on the basis of personality and role-based themes of one's self-concept. In two experiments, the extent to which different types of personal semantic content are reflected in these higher-order networks of memories was investigated. Healthy, young adult participants generated identity representations that varied in remoteness of formation and verbally reflected on these themes in an open-ended narrative task. The narrative responses were scored for retrieval of episodic, experience-near personal semantic and experience-far (i.e., abstract) personal semantic contents. Results revealed that to reflect on remotely formed identity representations, experience-far personal semantic contents were retrieved more than experience-near personal semantic contents. In contrast, to reflect on recently formed identity representations, experience-near personal semantic contents were retrieved more than experience-far personal semantic contents. Although episodic memory contents were retrieved less than both personal semantic content types to reflect on remotely formed identity representations, this content type was retrieved at a similar frequency as experience-far personal semantic content to reflect on recently formed identity representations. These findings indicate that the association of personal semantic content to identity representations is robust and related to time since acquisition of these knowledge structures.

Differences in the content and coherence of autobiographical memories between younger and older adults: Insights from text analysis.

Several studies have shown that older adults generate autobiographical memories with fewer specific details than younger adults, a pattern typically attributed to age-relate declines in episodic memory. A relatively unexplored question is how aging affects the content used to represent and recall these memories. We recently proposed that older adults may predominately represent and recall autobiographical memories at the gist level. Emerging from this proposal is the hypothesis that older adults represent memories with a wider array of content topics and recall memories with a distinct narrative style when compared to younger adults. We tested this hypothesis by applying natural language processing approaches to a data set of autobiographical memories described by healthy younger and older adults. We used topic modeling to estimate the distribution (i.e., diversity) of content topics used to represent a memory, and sentence embedding to derive an internal similarity score to estimate the shifts in content when narrating a memory. First, we found that older adults referenced a wider array of content topics (higher content diversity) than younger adults when recalling their autobiographical memories. Second, we found older adults were included more content shifts when narrating their memories than younger adults, suggesting a reduced reliance on choronology to form a coherent memory. Third, we found that the content diversity measures were positively related to specific detail generation for older adults, potentially reflecting age-related compensation for episodic memory difficulties. We discuss how our results shed light on how younger and older adults differ in the way they remember and describe the past. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Speaking Well and Feeling Good: Age-Related Differences in the Affective Language of Resting State Thought.

Despite the prevalence and importance of resting state thought for daily functioning and psychological well-being, it remains unclear how such thoughts differ between young and older adults. Age-related differences in the affective tone of resting state thoughts, including the affective language used to describe them, could be a novel manifestation of the positivity effect, with implications for well-being. To examine this possibility, a total of 77 young adults (M = 24.9 years, 18-35 years) and 74 cognitively normal older adults (M = 68.6 years, 58-83 years) spoke their thoughts freely during a think-aloud paradigm across two studies. The emotional properties of spoken words and participants' retrospective self-reported affective experiences were computed and examined for age differences and relationships with psychological well-being. Study 1, conducted before the start of the COVID-19 pandemic, revealed that older adults exhibited more diversity of positive, but not negative, affectively tinged words compared to young adults and more positive self-reported thoughts. Despite being conducted virtually during the COVID-19 pandemic, study 2 replicated many of study 1's findings, generalizing results across samples and study contexts. In an aggregated analysis of both samples, positive diversity predicted higher well-being beyond other metrics of affective tone, and the relationship between positive diversity and well-being was not moderated by age. Considering that older adults also exhibited higher well-being, these results hint at the possibility that cognitively healthy older adults' propensity to experience more diverse positive concepts during natural periods of restful thought may partly underlie age-related differences in well-being and reveal a novel expression of the positivity effect. Supplementary Information: The online version contains supplementary material available at 10.1007/s42761-024-00239-z.