Detalhe da pesquisa
1.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc Natl Acad Sci U S A;
118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34548400
2.
Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome.
J Am Chem Soc;
136(39): 13562-5, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25226494
3.
Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
Biochem J;
430(3): 461-76, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20632995
4.
Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Bioorg Med Chem Lett;
20(22): 6581-6, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20875739
5.
Spontaneous Extracellular Matrix Accumulation in a Human in vitro Model of Renal Fibrosis Is Mediated by αV Integrins.
Nephron;
142(4): 328-350, 2019.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31048591
6.
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome.
J Med Chem;
61(22): 10053-10066, 2018 11 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30373366
7.
Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma.
PLoS One;
12(1): e0168680, 2017.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28045928
8.
Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi.
Toxicol Res (Camb);
5(6): 1619-1628, 2016 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30090462
9.
KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism.
PLoS One;
10(12): e0144825, 2015.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26709701
10.
Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea.
Cancer Chemother Pharmacol;
68(5): 1145-54, 2011 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21400028
11.
Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies.
Clin Cancer Res;
17(23): 7313-23, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21903769
12.
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.
Cancer Res;
70(5): 1970-80, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20160034
13.
Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib.
Cancer Res;
70(11): 4318-26, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20460535
14.
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.
J Biol Chem;
277(17): 14838-43, 2002 Apr 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11815627
15.
Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins.
J Mol Cell Cardiol;
35(9): 1043-53, 2003 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12967627
16.
Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors.
J Am Chem Soc;
124(40): 11852-3, 2002 Oct 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12358520