Detalhe da pesquisa
1.
Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington's disease model.
Hum Mol Genet;
2024 May 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38776957
2.
From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington's Disease Research.
Int J Mol Sci;
24(16)2023 Aug 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37629202
3.
A Review of the Current Mammalian Models of Alzheimer's Disease and Challenges That Need to Be Overcome.
Int J Mol Sci;
22(23)2021 Dec 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34884970
4.
A new mechanism for a familiar mutation - bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement.
BMC Genomics;
21(1): 591, 2020 Aug 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32847516
5.
Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.
Proc Natl Acad Sci U S A;
114(52): E11293-E11302, 2017 12 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29229845
6.
Somatic CAG Repeat Stability in a Transgenic Sheep Model of Huntington's Disease.
J Huntingtons Dis;
13(1): 33-40, 2024.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38393920
7.
Characterisation of PDGF-BB:PDGFRß signalling pathways in human brain pericytes: evidence of disruption in Alzheimer's disease.
Commun Biol;
5(1): 235, 2022 03 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35301433
8.
A Multi-Omic Huntington's Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis.
J Huntingtons Dis;
10(4): 423-434, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34420978
9.
PU.1 regulates Alzheimer's disease-associated genes in primary human microglia.
Mol Neurodegener;
13(1): 44, 2018 08 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30124174
10.
Alzheimer's disease markers in the aged sheep (Ovis aries).
Neurobiol Aging;
58: 112-119, 2017 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28728117
11.
Potential molecular consequences of transgene integration: The R6/2 mouse example.
Sci Rep;
7: 41120, 2017 01 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28120936
12.
Metabolic disruption identified in the Huntington's disease transgenic sheep model.
Sci Rep;
6: 20681, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26864449
13.
Further molecular characterisation of the OVT73 transgenic sheep model of Huntington's disease identifies cortical aggregates.
J Huntingtons Dis;
2(3): 279-95, 2013.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25062676