Detalhe da pesquisa
1.
Heterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion.
Proc Natl Acad Sci U S A;
120(15): e2221060120, 2023 04 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37014866
2.
Loss of small GTPase Rab7 activation in prion infection negatively affects a feedback loop regulating neuronal cholesterol metabolism.
J Biol Chem;
299(2): 102883, 2023 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36623732
3.
Peptide aptamer targeting Aß-PrP-Fyn axis reduces Alzheimer's disease pathologies in 5XFAD transgenic mouse model.
Cell Mol Life Sci;
80(6): 139, 2023 May 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37149826
4.
New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene.
PLoS Pathog;
17(7): e1009795, 2021 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34310662
5.
Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD.
Acta Neuropathol;
144(4): 767-784, 2022 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35996016
6.
Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis.
Int J Mol Sci;
22(5)2021 Feb 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33668798
7.
Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression.
J Neurochem;
152(6): 727-740, 2020 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31553058
8.
Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency.
PLoS Pathog;
13(8): e1006553, 2017 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28800624
9.
Region-specific protein misfolding cyclic amplification reproduces brain tropism of prion strains.
J Biol Chem;
292(40): 16688-16696, 2017 10 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28821618
10.
Cycline efficacy on the propagation of human prions in primary cultured neurons is strain-specific.
J Infect Dis;
209(7): 1144-8, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24265435
11.
Prion propagation and toxicity occur in vitro with two-phase kinetics specific to strain and neuronal type.
J Virol;
87(5): 2535-48, 2013 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23255799
12.
Chronic wasting disease: Emerging prions and their potential risk.
PLoS Pathog;
13(11): e1006619, 2017 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29095921
13.
Propagation of PrPSc in mice reveals impact of aggregate composition on prion disease pathogenesis.
Commun Biol;
6(1): 1162, 2023 Nov 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37964018
14.
Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice.
Acta Neuropathol Commun;
9(1): 58, 2021 04 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33795005
15.
Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material.
J Vis Exp;
(127)2017 09 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28994814
16.
Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion.
PLoS One;
11(11): e0166187, 2016.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27829062
17.
Cholesterol balance in prion diseases and Alzheimer's disease.
Viruses;
6(11): 4505-35, 2014 Nov 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25419621
18.
PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.
Nat Med;
19(9): 1124-31, 2013 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23955714