Detalhe da pesquisa
1.
Synthesis of NVS-BPTF-1 and evaluation of its biological activity.
Bioorg Med Chem Lett;
47: 128208, 2021 09 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34146702
2.
RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease.
Mol Pharmacol;
92(6): 694-706, 2017 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28974538
3.
Novel approaches to targeting BRD4.
Drug Discov Today Technol;
24: 19-24, 2017 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29233295
4.
BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma.
Proc Natl Acad Sci U S A;
111(26): E2721-30, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24979794
5.
RVX-297- a novel BD2 selective inhibitor of BET bromodomains.
Biochem Biophys Res Commun;
477(1): 62-67, 2016 08 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27282480
6.
Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.
Bioorg Med Chem Lett;
25(14): 2818-23, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26022843
7.
Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2.
ACS Omega;
6(33): 21327-21338, 2021 Aug 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34471737
8.
The phytochemical piceatannol induces the loss of CBL and CBL-associated proteins.
Mol Cancer Ther;
8(3): 602-14, 2009 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19258424
9.
Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine.
J Med Chem;
61(18): 8202-8211, 2018 09 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30165024
10.
A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice.
Atherosclerosis;
236(1): 91-100, 2014 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25016363
11.
In vitro biosynthesis, isolation, and identification of predominant metabolites of 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (RVX-208).
Eur J Med Chem;
64: 121-8, 2013 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23644195
12.
RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist.
PLoS One;
8(12): e83190, 2013.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24391744
13.
Stilbene analogs as inducers of apolipoprotein-I transcription.
Eur J Med Chem;
45(5): 2018-23, 2010 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20106565
14.
RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo.
J Am Coll Cardiol;
55(23): 2580-9, 2010 Jun 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20513599
15.
Identification of novel macrocyclic peptidase substrates via on-bead enzymatic cyclization.
J Org Chem;
68(22): 8459-64, 2003 Oct 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14575471
16.
Interaction of the verotoxin 1B subunit with soluble aminodeoxy analogues of globotriaosyl ceramides.
Biochem J;
368(Pt 3): 769-76, 2002 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12175338