Detalhe da pesquisa
1.
UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
Mol Cell;
83(15): 2753-2767.e10, 2023 08 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37478846
2.
MEN1 mutations mediate clinical resistance to menin inhibition.
Nature;
615(7954): 913-919, 2023 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36922589
3.
Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.
Blood;
143(15): 1513-1527, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38096371
4.
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
J Biol Chem;
291(25): 13014-27, 2016 Jun 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27056325
5.
High-throughput oncogene mutation profiling in human cancer.
Nat Genet;
39(3): 347-51, 2007 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17293865
6.
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
PLoS Genet;
8(7): e1002772, 2012.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22829774
7.
High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade.
Blood;
117(8): 2433-40, 2011 Feb 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21209378
8.
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia.
Cancer Discov;
13(3): 746-765, 2023 03 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36455613
9.
KDM6A epigenetically regulates subtype plasticity in small cell lung cancer.
Nat Cell Biol;
25(9): 1346-1358, 2023 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37591951
10.
Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.
Clin Cancer Res;
29(22): 4613-4626, 2023 11 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37725576
11.
MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor.
Cancer Discov;
12(7): 1804-1823, 2022 07 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35499757
12.
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia.
Nat Cancer;
3(5): 595-613, 2022 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35534777
13.
Drug-sensitive FGFR2 mutations in endometrial carcinoma.
Proc Natl Acad Sci U S A;
105(25): 8713-7, 2008 Jun 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18552176
14.
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.
Proc Natl Acad Sci U S A;
104(50): 20007-12, 2007 Dec 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18077431
15.
A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.
Cancer Cell;
36(6): 660-673.e11, 2019 12 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31821784
16.
Using UMLS metathesaurus concepts to describe medical images: dermatology vocabulary.
Comput Biol Med;
36(1): 89-100, 2006 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16324910
17.
Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.
Cancer Res;
76(7): 1975-88, 2016 04 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26837761
18.
Preclinical Anticancer Efficacy of BET Bromodomain Inhibitors Is Determined by the Apoptotic Response.
Cancer Res;
76(6): 1313-9, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26759243
19.
Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma.
Elife;
52016 Jan 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26731516
20.
An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition.
PLoS One;
11(11): e0166438, 2016.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27875550