Detalhe da pesquisa
1.
A Gram-negative-selective antibiotic that spares the gut microbiome.
Nature;
630(8016): 429-436, 2024 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38811738
2.
Porin-independent accumulation in Pseudomonas enables antibiotic discovery.
Nature;
624(7990): 145-153, 2023 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37993720
3.
A new type of antibiotic targets a drug-resistant bacterium.
Nature;
625(7995): 451-452, 2024 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38172308
4.
Role of internal loop dynamics in antibiotic permeability of outer membrane porins.
Proc Natl Acad Sci U S A;
119(8)2022 02 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35193963
5.
Precise Readout of MEK1 Proteoforms upon MAPK Pathway Modulation by Individual Ion Mass Spectrometry.
Anal Chem;
96(11): 4455-4462, 2024 Mar 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38458998
6.
Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies.
Br J Cancer;
128(5): 783-792, 2023 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36470974
7.
Predictive compound accumulation rules yield a broad-spectrum antibiotic.
Nature;
545(7654): 299-304, 2017 05 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28489819
8.
Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy.
J Am Chem Soc;
144(27): 12367-12380, 2022 07 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35759775
9.
Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria.
Acc Chem Res;
54(6): 1322-1333, 2021 03 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33635073
10.
Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques.
J Am Chem Soc;
143(4): 2138-2155, 2021 02 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33464048
11.
Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity.
Angew Chem Int Ed Engl;
60(29): 16119-16128, 2021 07 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33973348
12.
Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch.
J Am Chem Soc;
142(24): 10856-10862, 2020 06 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32432858
13.
Re-engineering natural products to engage new biological targets.
Nat Prod Rep;
37(11): 1395-1403, 2020 11 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33034322
14.
How many human proteoforms are there?
Nat Chem Biol;
14(3): 206-214, 2018 02 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29443976
15.
Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations.
Angew Chem Int Ed Engl;
59(5): 1857-1862, 2020 01 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31793158
16.
Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene.
J Am Chem Soc;
141(1): 657-670, 2019 01 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30520639
17.
Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program.
Acta Neuropathol;
138(6): 1053-1074, 2019 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31428936
18.
Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species.
Invest New Drugs;
35(2): 134-144, 2017 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27975234
19.
Correction to "Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques".
J Am Chem Soc;
143(31): 12418, 2021 Aug 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34320318
20.
Deoxynyboquinones as NQO1-Activated Cancer Therapeutics.
Acc Chem Res;
48(10): 2715-23, 2015 Oct 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26444384