Detalhe da pesquisa
1.
Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease.
Ann Neurol;
92(5): 729-744, 2022 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36151869
2.
Development of a quantitative semi-mechanistic model of Alzheimer's disease based on the amyloid/tau/neurodegeneration framework (the Q-ATN model).
Alzheimers Dement;
19(6): 2287-2297, 2023 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36454709
3.
Impact of model misspecification on model-based tests in PK studies with parallel design: real case and simulation studies.
J Pharmacokinet Pharmacodyn;
49(5): 557-577, 2022 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36112338
4.
Characterization of [11C]RO5013853, a novel PET tracer for the glycine transporter type 1 (GlyT1) in humans.
Neuroimage;
75: 282-290, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22155032
5.
Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates.
CPT Pharmacometrics Syst Pharmacol;
12(1): 62-73, 2023 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36281062
6.
Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans.
MAbs;
15(1): 2261509, 2023.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37823690
7.
Disease Modeling and Model-Based Meta-Analyses to Define a New Direction for a Phase III Program of Gantenerumab in Alzheimer's Disease.
Clin Pharmacol Ther;
111(4): 857-866, 2022 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35100444
8.
In silico exploration of amyloid-related imaging abnormalities in the gantenerumab open-label extension trials using a semi-mechanistic model.
Alzheimers Dement (N Y);
8(1): e12306, 2022.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35676943
9.
Evaluation of dose-dependent treatment effects after mid-trial dose escalation in biomarker, clinical, and cognitive outcomes for gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.
Alzheimers Dement (Amst);
14(1): e12367, 2022.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36348972
10.
A Phase I Study to Assess the Effect of Speed of Injection on Pain, Tolerability, and Pharmacokinetics After High-volume Subcutaneous Administration of Gantenerumab in Healthy Volunteers.
Clin Ther;
42(1): 108-120.e1, 2020 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31883703
11.
Gantenerumab reduces amyloid-ß plaques in patients with prodromal to moderate Alzheimer's disease: a PET substudy interim analysis.
Alzheimers Res Ther;
11(1): 101, 2019 12 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31831056
12.
Assessment of Drug-Drug Interactions between Taspoglutide, a Glucagon-Like Peptide-1 Agonist, and Drugs Commonly Used in Type 2 Diabetes Mellitus: Results of Five Phase I Trials.
Clin Pharmacokinet;
58(9): 1205-1214, 2019 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30968335
13.
Correction to: A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease.
Alzheimers Res Ther;
10(1): 99, 2018 09 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30261916
14.
A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease.
Alzheimers Res Ther;
9(1): 95, 2017 Dec 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29221491
15.
Genes encoding enzymes responsible for biosynthesis of L-lyxose and attachment of eurekanate during avilamycin biosynthesis.
Chem Biol;
12(10): 1137-43, 2005 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16242656
16.
Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions.
Clin Pharmacokinet;
55(2): 237-47, 2016 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26341813
17.
Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers.
Psychopharmacology (Berl);
233(13): 2429-39, 2016 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27178435
18.
Novel avilamycin derivatives with improved polarity generated by targeted gene disruption.
Chem Biol;
11(10): 1403-11, 2004 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15489167
19.
Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene.
FEMS Microbiol Lett;
230(1): 91-7, 2004 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14734170
20.
Physiologically based pharmacokinetic modelling to predict single- and multiple-dose human pharmacokinetics of bitopertin.
Clin Pharmacokinet;
52(8): 673-83, 2013 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23591780