Detalhe da pesquisa
1.
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Cell;
184(12): 3143-3162.e32, 2021 06 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34004147
2.
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.
Cell;
184(15): 4032-4047.e31, 2021 07 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34171309
3.
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia.
Nat Immunol;
23(10): 1424-1432, 2022 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36138187
4.
GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies.
Mol Cell;
84(10): 1886-1903.e10, 2024 May 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38688280
5.
Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Mol Cell;
83(10): 1725-1742.e12, 2023 05 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37084731
6.
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.
Mol Cell;
81(10): 2183-2200.e13, 2021 05 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34019788
7.
Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma.
Proc Natl Acad Sci U S A;
120(36): e2306414120, 2023 09 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37643213
8.
Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors.
N Engl J Med;
386(8): 735-743, 2022 02 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35196427
9.
Whole genome CRISPR screening identifies TOP2B as a potential target for IMiD sensitization in multiple myeloma.
Haematologica;
106(7): 2013-2017, 2021 07 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33375771
10.
Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ.
Bioorg Med Chem Lett;
26(19): 4790-4794, 2016 10 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27561716
11.
PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity.
Cell Rep;
43(3): 113831, 2024 Mar 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38401121
12.
Covalent Targeting of Splicing in T Cells.
bioRxiv;
2023 Dec 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38187674
13.
Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia.
Nat Cancer;
4(12): 1675-1692, 2023 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37872381
14.
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity.
Cell Rep;
42(8): 113014, 2023 08 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37605534
15.
Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia.
Cancer Cell;
41(1): 164-180.e8, 2023 01 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36563682
16.
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia.
EMBO Mol Med;
14(7): e15203, 2022 07 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35514210
17.
Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer.
Clin Epigenetics;
14(1): 96, 2022 07 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35902886
18.
Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma.
Leukemia;
36(6): 1654-1665, 2022 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35459873
19.
BET Inhibition Enhances TNF-Mediated Antitumor Immunity.
Cancer Immunol Res;
10(1): 87-107, 2022 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34782346
20.
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.
Cancer Discov;
12(10): 2434-2453, 2022 10 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35904492