Use of MRI-based vertebral bone quality score (VBQ) of S1 body in bone mineral density assessment for patients with lumbar degenerative diseases.

PURPOSE: To evaluate the use of the modified and simplified vertebral bone quality (VBQ) method based on T1-weighted MRI images of S1 vertebrae in assessing bone mineral density (BMD) for patients with lumbar degenerative diseases. METHODS: We reviewed the preoperative data of patients with lumbar degenerative diseases undergoing lumbar spine surgery between January 2019 and June 2022 with available non-contrast T1-weighted magnetic resonance imaging (MRI), computed tomography (CT) images and dual-energy X-ray absorptiometry (DEXA). S1 vertebral bone quality scores (S1 VBQ) and S1 CT Hounsfield units were measured with picture archiving and communication system (PACS). One-way ANOVA was applied to present the discrepancy between the S1 VBQ of patients with normal bone density (T-score ≥ - 1.0), osteopenia (- 2.5 < T-score < - 1.0) and osteoporosis (T-score ≤ - 2.5). The receiver operating characteristic curve (ROC) was drawn to analyze the diagnostic performance of S1 VBQ in distinguishing low BMD. Statistical significance was set at p < 0.05. RESULTS: A total of 207 patients were included. The S1 VBQ were significantly different between groups (p < 0.001). Interclass correlation coefficient for inter-rater reliability was 0.86 (95% CI 0.78-0.94) and 0.94(95% CI 0.89-0.98) for intra-rater reliability. According to the linear regression analysis, the S1 VBQ has moderate-to-strong correlations with DEXA T-score (r = - 0.48, p < 0.001). The area under the ROC curve indicated a predictive accuracy of 82%. A sensitivity of 77.25% with a specificity of 70% could be achieved for distinguishing low BMD by setting the S1 VBQ cutoff as 2.93. CONCLUSIONS: The S1 VBQ was a promising tool in distinguishing poor bone quality in patients with lumbar degenerative diseases, especially in cases where the previously reported VBQ method based on L1-L4 was not available. S1 VBQ score could be useful as opportunistic assessment for screening and complementary evaluation to DEXA T-score before surgery.

Comparative analysis of the biomechanics of anterior cervical discectomy and fusion with multiple segmental plates fixation versus single multilevel plate fixation: a finite element study.

BACKGROUND: This study aimed to compare the biomechanical differences between anterior cervical discectomy and fusion (ACDF) with multiple-level separate plates and conventional long plates by using finite element analysis. METHODS: The following four finite element models were created to simulate various fixations: (1) C4-6 ACDF with multiple plates, (2) C4-6 ACDF with a single plate, (3) C3-6 ACDF with multiple plates, and (4) C3-6 ACDF with a single plate. The maximum Von-mises stress of the cage and fixation, compressive force of the adjacent intervertebral discs and range of motion (ROM) of different segments in the four models were calculated and analyzed. RESULTS: For C4-6 ACDF, the maximum Von-mises stress of the cage and fixation was lower in the multiple plate fixation model in all motion states. Similarly, for the C3-6 ACDF models, the peak stress of the C3-4 and C5-6 cages was lower with multiple plates fixation in all motions but the stress of the C4-5 cage in the multiple plates model was slightly higher in flexion, bending and rotation. Besides, applying multiple plates in C3-6 ACDF models resulted in a decreased maximum stress of the fixation under different motions except for bending. In both the C4-6 ACDF and C3-6 ACDF models, the ROM values of the adjacent motion segments were lower in the multiple plates models in extension, bending and rotation. In the C4-6 ACDF models, the peak stress on the adjacent intervertebral discs in the multiple plates models was slightly smaller. In C3-6 ACDF models, the maximum stress on the adjacent intervertebral discs was larger in the single-plate model under flexion, bending and rotation movements. CONCLUSION: Multiple plates fixation has a positive effect on increasing stiffness and maintaining the ROM of adjacent segments, indicating lower risk of construct failure and adjacent segment degeneration. Further studies are required to confirm its efficacy in clinical practice.

Optimization-Based Online Initialization and Calibration of Monocular Visual-Inertial Odometry Considering Spatial-Temporal Constraints.

The online system state initialization and simultaneous spatial-temporal calibration are critical for monocular Visual-Inertial Odometry (VIO) since these parameters are either not well provided or even unknown. Although impressive performance has been achieved, most of the existing methods are designed for filter-based VIOs. For the optimization-based VIOs, there is not much online spatial-temporal calibration method in the literature. In this paper, we propose an optimization-based online initialization and spatial-temporal calibration method for VIO. The method does not need any prior knowledge about spatial and temporal configurations. It estimates the initial states of metric-scale, velocity, gravity, Inertial Measurement Unit (IMU) biases, and calibrates the coordinate transformation and time offsets between the camera and IMU sensors. The work routine of the method is as follows. First, it uses a time offset model and two short-term motion interpolation algorithms to align and interpolate the camera and IMU measurement data. Then, the aligned and interpolated results are sent to an incremental estimator to estimate the initial states and the spatial-temporal parameters. After that, a bundle adjustment is additionally included to improve the accuracy of the estimated results. Experiments using both synthetic and public datasets are performed to examine the performance of the proposed method. The results show that both the initial states and the spatial-temporal parameters can be well estimated. The method outperforms other contemporary methods used for comparison.

Clinical effect and safety evaluation of different dosage of Rituximab combined with Cyclophosphamide in treatment of refractory immune Thrombocytopenia.

OBJECTIVE: To discuss clinical effect of different dosage of rituximab combined with cyclophosphamide in treatment of refractory immune thrombocytopenia (rITP). METHOD: This study was conducted at Department of Hematopathology in XX Hospital from January 2016 to January 2018. In this study. Seventy-eight patients with rITP were selected as the objects, divided into observation group (39 cases) and control group (39 cases) according to random number table. Patients in the control group were treated with conventional rituximab and cyclophosphamide, while the observation group received low-dose rituximab. The same amount of cyclophosphamide was used in the two groups. The statistics of clinical effect, recurrence rate, untoward effect and Laboratory inspection of both groups were made before and after the treatment. RESULTS: Compared with the control group, the total occurrence rate of side effects in the observation group decreased significantly; the level of IgM and CD20+ in the observation group also decreased significantly, while. The level of IgA, IgG, CD3+ and CD4+ rose significantly (P<0.05). The differences in the level of Th1, TNF-a, IL-18 and Sc5b-9 had statistical significance before and after the treatment (P<0.05). CONCLUSION: Rituximab combined with cyclophosphamide has the definite curative effect on rITP. The small dosage of rituximab combined with cyclophosphamide has higher clinical safety in the treatment.

Upregulation of Mitochondrial Transcription Factor A Promotes the Repairment of Renal Tubular Epithelial Cells in Sepsis by Inhibiting Reactive Oxygen Species-Mediated Toll-Like Receptor 4/p38MAPK Signaling.

BACKGROUND: Mitochondrial transcription factor A (TFAM) plays multiple pathophysiologic roles in mitochondrial DNA (mtDNA) maintenance. However, the role of TFAM in sepsis-induced acute kidney injury (AKI) remains largely unknown. METHODS: Lipopolysaccharide (LPS) treatment of HK-2 cells mimics the in vitro model of AKI inflammation. pcDNA3.1 plasmid was used to construct pcDNA3.1-TFAM. sh-TFAM-543, sh-TFAM-717, sh-TFAM-765, sh-TFAM-904 and pcDNA3.1-TFAM were transfected into HK-2 cells using Lipofectamine 2000. MtDNA transcriptional levels were detected by quantitative real-time polymerase chain reaction (qRT-PCR). 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay was performed to assess the cell viability. Changes in reactive oxygen species (ROS) and mitochondrial membrane potential in HK-2 cells were detected using the corresponding kits. Immunofluorescence experiment was used to investigate the displacement of TFAM. mRNA and protein expression levels of TFAM and its related genes were measured by qRT-PCR and western blot respectively. Mice in sepsis were administered cecal ligation and puncture surgery. RESULTS: LPS treatment was a non-lethal influencing factor, leading to the upregulation of ROS levels and downregulation of mtDNA copy number and NADH dehydrogenase subunit-1 (ND1) expression, and caused damage to the mitochondria. As the LPS treatment time increased, TFAM was displaced from the periphery of the nucleus to cytoplasm. TFAM reduced ROS and P38MAPK levels by inhibiting toll-like receptor 4 (TLR4) expression, ultimately inhibiting inflammation and repairing mtDNA. CONCLUSIONS: Our results indicate that TFAM repairs mtDNA by blocking the TLR4/ROS/P38MAPK signaling pathway in inflammatory cells, thereby repairing septic tubular epithelial cells, and TFAM may serve as a new target for sepsis therapy.

Recent Developments in Polyurea Research for Enhanced Impact Penetration Resistance and Blast Mitigation.

Polyurea has gained significant attention in recent years as a functional polymer material, specifically regarding blast and impact protection. The molecular structure of polyurea is characterized by the rapid reaction between isocyanate and the terminal amine component, and forms an elastomeric copolymer that enhances substrate protection against blast impact and fragmentation penetration. At the nanoscale, a phase-separated microstructure emerges, with dispersed hard segment microregions within a continuous matrix of soft segments. This unique microstructure contributes to the remarkable mechanical properties of polyurea. To maximize these properties, it is crucial to analyze the molecular structure and explore methods like formulation optimization and the incorporation of reinforcing materials or fibers. Current research efforts in polyurea applications for protective purposes primarily concentrate on construction, infrastructure, military, transportation and industrial products and facilities. Future research directions should encompass deliberate formulation design and modification, systematic exploration of factors influencing protective performance across various applications and the integration of numerical simulations and experiments to reveal the protective mechanisms of polyurea. This paper provides an extensive literature review that specifically examines the utilization of polyurea for blast and impact protection. It encompasses discussions on material optimization, protective mechanisms and its applications in blast and impact protection.

High Sensitivity and Wide Linear Range Flexible Piezoresistive Pressure Sensor with Microspheres as Spacers for Pronunciation Recognition.

Flexible piezoresistive pressure sensors have received great popularity in flexible electronics due to their simple structure and promising applications in health monitoring and artificial intelligence. However, the contradiction between sensitivity and detection range limits the application of the sensors in the medium-pressure regime. Here, a flexible piezoresistive pressure sensor is fabricated by combining a hierarchical spinous microstructure sensitive layer and a periodic microsphere array spacer. The sensor achieves high sensitivity (39.1 kPa-1) and outstanding linearity (0.99, R2 coefficient) in a medium-pressure regime, as well as a wide range of detection (100 Pa-160.0 kPa), high detection precision (<0.63‰ full scale), and excellent durability (>5000 cycles). The mechanism of the microsphere array spacer in improving sensitivity and detection range was revealed through finite element analysis. Furthermore, the sensors have been utilized to detect muscle and joint movements, spatial pressure distributions, and throat movements during pronouncing words. By means of a full-connect artificial neural network for machine learning, the sensor's output of different pronounced words can be precisely distinguished and classified with an overall accuracy of 96.0%. Overall, the high-performance flexible pressure sensor based on a microsphere array spacer has great potential in health monitoring, human-machine interface, and artificial intelligence of medium-pressure regime.

Different Degrees of Sulfated Laminaria Polysaccharides Recovered Damaged HK-2 Cells and Inhibited Adhesion of Nano-COM and Nano-COD Crystals.

Purpose: The crystal adhesion caused by the damage of renal tubular epithelial cells (HK-2) is the key to the formation of kidney stones. However, no effective preventive drug has been found. This study aims to explore the recovery effects of four Laminaria polysaccharides (SLPs) with different sulfate (-OSO3-) contents on damaged HK-2 cells and the difference in the adhesion of damaged cells to nanometer calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD) before and after recovery. Methods: Sodium oxalate (2.6 mmol/L) was used to damage HK-2 cells to establish a damaged model. SLPs (LP0, SLP1, SLP2, and SLP3) with -OSO3- contents of 0.73%, 15.1%, 22.8%, and 31.3%, respectively, were used to restore the damaged cells, and the effects of SLPs on the adhesion of COM and COD, with a size of about 100 nm before and after recovery, were measured. Results: The following results were observed after SLPs recovered the damaged HK-2 cells: increased cell viability, restored cell morphology, decreased reactive oxygen levels, increased mitochondrial membrane potential, decreased phosphatidylserine eversion ratio, increased cell migration ability, reduced expression of annexin A1, transmembrane protein, and heat shock protein 90 on the cell surface, and reduced adhesion amount of cells to COM and COD. Under the same conditions, the adhesion ability of cells to COD crystals was weaker than that to COM crystals. Conclusions: As the sulfate content in SLPs increases, the ability of SLPs to recover damaged HK-2 cells and inhibit crystal adhesion increases. SLP3 with high -OSO3- content may be a potential drug to prevent kidney stones.

Establishment of the Lunar Phase Morphological Classification for Cervical Spinal Canal.

STUDY DESIGN: Retrospective clinical trial. PURPOSE: To establish a morphological classification of the cervical spinal canal using its parameters. OVERVIEW OF LITERATURE: Cervical spine computed tomography (CT) data of 200 healthy volunteers in 2 years were analyzed. The morphology of the spinal cord was also analyzed. METHODS: The median sagittal diameter and transverse diameter of the spinal canal from C2 to C7 were measured on CT images. The ratio of the median sagittal diameter to the transverse diameter was calculated. Accordingly, the spinal canal shape of each segment was classified into four, and the specific criteria of lunar phase classification were determined through linear discriminant analysis based on the ratio of the median sagittal diameter to the transverse diameter. The inter-rater reliability of the classification was explored using Kappa coefficients. Finally, the morphology of the different segments of the cervical spinal canal in healthy volunteers was revised and compared. RESULTS: According to the ratio of the median sagittal diameter and the transverse diameter of the cervical spinal canal, the lunar phase classification of the cervical bony spinal canal was determined as follows: full-moon >0.65, 0.55< convex-moon ≤0.65, 0.46≤ quarter-moon ≤0.55, and residual-moon <0.46. The Kappa values of C2-C7 were 0.851, 0.958, 0.823, 0.927, 0.793, and 0.946, and the Kappa value of all C2-C7 segments was 0.854 that mainly presented two forms of full-moon (76.5%) and convex-moon (23.0%). A quarter-moon spinal canal was mainly distributed in C3, C4, C5, and C6; a residual-moon spinal canal was mainly distributed in C4 and C5; and the morphological distribution of C4 and C5 were similar (p>0.05). The frequency of the spinal canal of the residual-moon type was the highest, and the full-moon (6.5%) and residual-moon (7.5%) types of C7 were rare. CONCLUSIONS: The morphological classification of the cervical spinal canal was established to present anatomical variations. The classification showed good inter-rater reliability.

Flexible, Transparent and Conductive Metal Mesh Films with Ultra-High FoM for Stretchable Heating and Electromagnetic Interference Shielding.

Despite the growing demand for transparent conductive films in smart and wearable electronics for electromagnetic interference (EMI) shielding, achieving a flexible EMI shielding film, while maintaining a high transmittance remains a significant challenge. Herein, a flexible, transparent, and conductive copper (Cu) metal mesh film for EMI shielding is fabricated by self-forming crackle template method and electroplating technique. The Cu mesh film shows an ultra-low sheet resistance (0.18 Ω â–¡-1), high transmittance (85.8%@550 nm), and ultra-high figure of merit (> 13,000). It also has satisfactory stretchability and mechanical stability, with a resistance increases of only 1.3% after 1,000 bending cycles. As a stretchable heater (ε > 30%), the saturation temperature of the film can reach over 110 °C within 60 s at 1.00 V applied voltage. Moreover, the metal mesh film exhibits outstanding average EMI shielding effectiveness of 40.4 dB in the X-band at the thickness of 2.5 µm. As a demonstration, it is used as a transparent window for shielding the wireless communication electromagnetic waves. Therefore, the flexible and transparent conductive Cu mesh film proposed in this work provides a promising candidate for the next-generation EMI shielding applications.

Prefabrication of "Trinity" Functional Binary Layers on a Silicon Surface to Develop High-Performance Lithium-Ion Batteries.

The silicon (Si) anode is widely recognized as the most prospective next-generation anode. To promote the application of Si electrodes, it is imperative to address persistent interface side reactions caused by the huge volume expansion of Si particles. Herein, we introduce beneficial groups of the optimized binder and electrolyte on the Si surface by a co-dissolution method, realizing a "trinity" functional layer composed of azodicarbonamide and 4-nitrobenzenesulfonyl fluoride (AN). The "trinity" functional AN interfacial layer induces beneficial reductive decomposition reactions of the electrolyte and forms a hybrid solid-electrolyte interphase (SEI) skin layer with uniformly distributed organic/inorganic components, which can enhance the mechanical strength of the overall electrode, restrain harmful electrolyte depletion reactions, and maintain efficient ion/electron transport. Hence, the optimized Si@AN11 electrode retains 1407.9 mAh g-1 after 500 cycles and still delivers 1773.5 mAh g-1 at 10 C. In stark contrast, Si anodes have almost no reserved capacity at the same test conditions. Besides, the LiNi0.5Co0.2Mn0.3O2//Si@AN11 full-cell maintains 141.2 mAh g-1 after 350 cycles. This work demonstrates the potential of developing multiple composite artificial layers to modulate the SEI properties of various next-generation electrodes.

Cell Protection and Crystal Endocytosis Inhibition by Sulfated Laminaria Polysaccharides Against Nano-COM-Induced Oxidative Damage in Renal Epithelial Cells.

Background: The damage to renal tubular epithelial cells is closely related to the formation of kidney stones. At present, research on drugs that can protect cells from damage remains limited. Methods: This study aims to explore the protective effects of four different sulfate groups (-OSO3 -) of Laminaria polysaccharides (SLPs) on human kidney proximal tubular epithelial (HK-2) cells and determine the difference in the endocytosis of nano-sized calcium oxalate monohydrate (COM) crystals before and after protection. COM with a size of 230 ± 80 nm was used to damage HK-2 cells to establish a damage model. The protection capability of SLPs (LP0, SLP1, SLP2, and SLP3) with -OSO3 - contents of 0.73, 15, 23, and 31%, respectively, against COM crystal damage and the effect of SLPs on the endocytosis of COM crystals were studied. Results: Compared with that of the SLP-unprotected COM-injured group, the cell viability of the SLP-protected group was improved, healing capability was enhanced, cell morphology was restored, production of reactive oxygen species was reduced, mitochondrial membrane potential and lysosome integrity were increased, intracellular Ca2+ level and autophagy were decreased, cell mortality was reduced, and internalized COM crystals were lessened. The capability of SLPs to protect cells from damage and inhibit the endocytosis of crystals in cells enhanced with an increase in the -OSO3 - content of SLPs. Conclusions: SLPs with a high -OSO3 - content may become a potential green drug for preventing the formation of kidney stones.

Two-step phase manipulation by tailoring chemical bonds results in high-performance GeSe thermoelectrics.

In thermoelectrics, phase engineering serves a crucial function in determining the power factor by affecting the band degeneracy. However, for low-symmetry compounds, the mainstream one-step phase manipulation strategy, depending solely on the valley or orbital degeneracy, is inadequate to attain a high density-of-states effective mass and exceptional zT. Here, we employ a distinctive two-step phase manipulation strategy through stepwise tailoring chemical bonds in GeSe. Initially, we amplify the valley degeneracy via CdTe alloying, which elevates the crystal symmetry from a covalently bonded orthorhombic to a metavalently bonded rhombohedral phase by significantly suppressing the Peierls distortion. Subsequently, we incorporate Pb to trigger the convergence of multivalence bands and further enhance the density-of-states effective mass by moderately restraining the Peierls distortion. Additionally, the atypical metavalent bonding in rhombohedral GeSe enables a high Ge vacancy concentration and a small band effective mass, leading to increased carrier concentration and mobility. This weak chemical bond along with strong lattice anharmonicity also reduces lattice thermal conductivity. Consequently, this unique property ensemble contributes to an outstanding zT of 0.9 at 773 K for Ge0.80Pb0.20Se(CdTe)0.25. This work underscores the pivotal role of the two-step phase manipulation by stepwise tailoring of chemical bonds in improving the thermoelectric performance of p-bonded chalcogenides.

Synthesis of sugar gourd-like metal organic framework-derived hollow nanocages nickel molybdate@cobalt-nickel layered double hydroxide for flame retardant polyurea.

Transition metals with catalytic properties were expected to improve the fire resistance of the polymer. In this work, NiMoO4 nanorods decorated with Co-Ni layered double hydroxide (LDH) were fabricated and incorporated into polyurea (PUA) to improve the flame retardancy during combustion. Thermogravimetric analysis (TGA) showed that the addition of NiMoO4@Co-Ni LDH slightly decreased the initial degradation and the maximum degradation temperature. With increasing loading of NiMoO4@Co-Ni LDH, the char residue increased obviously. The combustion performance of PUA with 3.0 wt% NiMoO4@Co-Ni LDH investigated by cone calorimeter (CCT) showed that the peak heat release rate (PHRR), total heat release (THR) and smoke factor (SF) decreased by 34.41%, 12.68% and 48.65%, respectively. The existence of well-dispersed NiMoO4@Co-Ni LDH effectively enhanced the mechanical properties and flame retardant performances of PUA.

Explosion Test and Numerical Simulation of Coated Reinforced Concrete Slab Based on BLAST Mitigation Polyurea Coating Performance.

The mechanical strength, thermal stability, thermal performance, and microstructure of Qtech T26 blast mitigation polyurea (T26 polyurea) were studied using quasi-static and dynamic mechanical experiments, thermogravimetric experiments, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) experiments, and contact explosion and non-contact explosion experiments with polyurea-coated reinforced concrete slabs. Additionally, the energy dissipation mechanism of the coating was analyzed. The blast mitigation ability and blast mitigation mechanism of T26 polyurea-coated reinforced concrete slabs were investigated by analyzing the macroscopic morphology of reinforced concrete slabs with or without coatings and the contact explosion simulation of polyurea-coated reinforced concrete slabs. The results showed that T26 polyurea exhibited a certain strain rate effect. Its initial thermal decomposition temperature reached 286 °C, and its thermal stability was good. After carbonization, carbon slag can form and adhere to the structural surface. The glass transition temperature Tgs of the soft segment was -44.9 °C, and the glass transition temperature Tgh of the hard segment was 36.5 °C, showing a certain amount of microphase separation morphology. After the explosion test, there was a small pit on the front surface of the coated reinforced concrete plate, and there was no damage on the back surface. The integrity of the plate was good. The uncoated reinforced concrete slab had a large crater on the front of the explosion surface, and the back of the explosion surface experienced explosion collapse, concrete crushing, and an overall loss of stability. The numerical simulation results showed that the failure mode of the coated plate was consistent with the test. The kinetic energy conversion rate of the uncoated reinforced concrete plate was 87.27%, and the kinetic energy conversion rate of the coated reinforced concrete plate was 95.36%. The T26 coating improved the kinetic energy conversion rate of the structure and improved the blast mitigation ability of the reinforced concrete plate structure.

Preoperative Assessment of Bone Density Using MRI-Based Vertebral Bone Quality Score Modified for Patients Undergoing Cervical Spine Surgery.

STUDY DESIGN: Diagnostic accuracy study. OBJECTIVES: Previous studies have reported the clinical application of the Vertebral Bone Quality (VBQ) scores for assessing bone density in operative lumbar spine patients. We aim to explore whether the method could be modified and applicable for patients undergoing cervical spine surgery. METHODS: Adult patients receiving cervical spine surgery for degenerative diseases between September 2020 and March 2022 with non-contrast T1-weighted MRI and DEXA were included. Correlation between cervical VBQ scores and DEXA T-scores was analyzed using Pearson's correlation. Student's t test was used to present the discrepancy between the VBQ of patients with normal bone density (T ≥ -1.0) and patients with osteopenia/osteoporosis (T < -1.0). Statistical significance was set at P < .05. RESULTS: Eighty-three patients (20 patients with T ≥ -1.0 vs 63 patients with T < -1.0 ) were included. Significant difference was found between the cervical VBQ between groups (2.99 ± .79 vs 3.80 ± .81, P < .001). Interclass correlation coefficient for inter-rater reliability was .82 (95% CI: .70-.93) and .91(95% CI: .84-.97) for intra-rater reliability. The area under the ROC curve was .78 (95% CI: .65-.90). The DEXA T-score of the femoral neck, total hip and the lowest DEXA T-score were found to be significantly correlated with the cervical VBQ score according to Pearson correlation analysis (P < .001). CONCLUSIONS: This is the first study to apply the VBQ method to assess the bone density in preoperative cervical spine patients. Cervical VBQ scores were significantly correlated with DEXA T-score. With an overall accuracy of .78, the radiation-free and cost-effective method could be a potential tool for screening patients with osteopenia and osteoporosis before surgery.

Study of Blast Mitigation Performance and Fracture Mechanism of Polyurea under Contact Explosion.

In order to further study the blast mitigation performance of polyurea and to investigate the protection mechanism and damage characteristics of polyurea-protected structures under contact explosion loads, based on earlier work, this paper investigated the response and energy absorption performance of polyurea under various frequency loads. Qtech T26 blast mitigation polyurea (T26 polyurea) was adopted to protect the reinforced concrete (RC) slab and damage analysis of the post-explosion specimens was carried out at micro and macro levels. The response and energy absorption capacity of the material towards different frequency loads were investigated by dynamic mechanical analysis (DMA). Protective performance of T26 polyurea on RC slab was examined with a 10 kg TNT contact explosion test. Scanning electron microscopy (SEM) was employed to analyze the microscopic fracture morphology of the typical areas of the coating after the explosion. The chemical structure changes of the blast-face coating before and after the explosion were compared by Fourier transform infrared spectroscopy (FTIR). The results show that the glass transition region of T26 polyurea is -40 °C to 10 °C, which is a large temperature range, and the microphase separation of T26 polyurea is low. It is significantly influenced by the ambient temperature and loading frequency. The energy absorption of T26 polyurea is realized through the interaction between the hard and soft segments. When the frequency is between 102 Hz and 106 Hz, the loss factor of T26 polyurea is between 0.20 and 0.31, which exhibits a good energy dissipation performance. In the contact explosion of 10 kg TNT, the fragmentation rate of the coated specimen decreased significantly compared with that of the unprotected specimen, realizing the zero fragmentation protection effect on the back-blast face. The maximum deformation area and the main energy absorption area of T26 polyurea under contact explosion is the ring area outside the longitudinal deformation area. The chemical structure of T26 polyurea changed significantly after the explosion; typically the N-H bonds, etc., were broken and the percentage of hydrogen bonding was reduced. T26 polyurea has realized the protection effect of zero fragmentation of large-equivalent contact explosion, which has a high application value for blast mitigation and blast-fragmentation prevention in actual engineering.

Biomechanical evaluation of a novel anatomical plate for oblique lumbar interbody fusion compared with various fixations: a finite element analysis.

Background: To build a model of an anatomical plate for oblique lumbar interbody fusion (OLIF) surgery based on previous anatomical parameters and verify the biomechanical effect with finite element analysis. Methods: The anatomical plate model was built with AutoCAD and Solidworks. Finite element models of the L2-3 and L4-5 segments were established with computed tomography images from a 46-year-old asymptomatic male individual. Six fixation technique models were created: (I) stand-alone (SA); (II) bilateral pedicle screws (BPS); (III) lateral rod-screw (LRS); (IV) lateral rod-screw plus facet screw (LRSFS); (V) two-screw lateral plate (TSLP); (VI) anatomical plate. The range of motion (ROM), the cage stress, and the instrument stress were calculated under different motion states. Results: In the L2-3 and L4-5 segment models, except for a slightly higher maximum cage stress in the extension state of the TSLP model and the right bending and rotation states of the BPS model, the maximum cage stress in each model was smaller than that of the SA model. In the L2-3 and L4-5 segments, each internal fixation limited the ROM in each motion state. The anatomical plate was more effective in reducing the maximum cage stress and vertebral ROM than the two-screw plate. Three-dimensional finite element analysis did not find a higher risk of construct failure for the anatomical plate model compared with the BPS internal fixation model. Conclusions: Anatomical plates can be considered as supplementary fixations using a single incision and position to improve the stability and rigidity of the construction and reduce the risk of complications.

Construction of a LiF-Rich and Stable SEI Film by Designing a Binary, Ion-, and Electron-Conducting Buffer Interface on the Si Surface.

Stabilizing a solid electrolyte interface (SEI) film on the Si surface is a prerequisite for realizing silicon (Si) anode applications. Interfacial engineering is one of the effective strategies to construct stable SEI films on Si surfaces and improve the electrochemical performance of the Si anodes. This work develops a silver (Ag)-decorated mucic acid (MA) buffer interface on the Si surface and the obtained Si@MA*Ag anode retains 1567 mAh g-1 after 500 cycles at 2.1 A g-1 and exhibits 1740 mAh g-1 at 126 A g-1, which are significantly higher than those of the bare Si anode of 247 and 145 mAh g-1 under the same conditions, respectively. Analysis indicates that the improved electrochemical performance is because of the depressed volume effect of the Si particles and the sustained integrity of the electrode laminate during cycling, the enhanced lithium diffusion on the Si surface, and the improved electronic conductivity of the Si anode, as well as the facilitated formation of inorganic components in the SEI film.

Hemoglobin-catalyzed atom transfer radical polymerization for ultrasensitive electrochemical DNA detection.

The use of hemoglobin (Hb) to drive atom transfer radical polymerization (ATRP) process (Hb-ATRP) for detection of lung cancer related nucleic acid is firstly reported. Hb does not need to be treated prior to using indicating the potential for synthetic engineering in complex biological microenvironments without the need for in vitro techniques. Here, we report a new signal amplification strategy using Hb-mediated graft of nitronyl niroxide monoradical polymers as a signal-on electrochemical biosensor for ultralow level DNA highly selective detection. Building DNA biosensors includes: (i) the fixation of peptide nucleic acid (PNA) probe (no phosphate group) via the 5' terminus-SH; (ii) the modification of transition metal; (iii) Site-specific markers of Hb-ATRP promoter, and (iv) the grafting of polymers with electrochemical signal by Hb-ATRP process. Through the Hb-ATRP process of nitronyl nitroxide monoradical (TEMPO), the presence of a small amount of DNA can eventually result in calling a certain number of TEMPO redox tags. Obviously, the Hb-ATRP is a method of easy source of raw materials, simple operation and no need for complex equipment. The constructed biosensor, as expected, is highly selective and sensitive to target DNA. The detection limit can be calculated as 15.96 fM under optimal conditions. The excellent performance also shows that the constructed DNA biosensor is suitable for DNA screening and DNA concentration determination in complex sample matrix.