Detalhe da pesquisa
1.
Aurora kinase A inhibitor, LY3295668 erbumine: a phase 1 monotherapy safety study in patients with locally advanced or metastatic solid tumors.
Invest New Drugs;
39(4): 1001-1010, 2021 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33479856
2.
An evaluation of metabolite profiling of six drugs using dried blood spot.
Xenobiotica;
49(12): 1458-1469, 2019 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30694093
3.
Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse.
J Pharm Pharm Sci;
19(4): 496-510, 2016.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28057168
4.
Utilizing 19F NMR to investigate drug disposition early in drug discovery.
Xenobiotica;
45(12): 1081-91, 2015.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25946562
5.
LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.
Invest New Drugs;
31(4): 833-44, 2013 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23275061
6.
Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1.
Cell Rep Med;
4(11): 101282, 2023 11 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37992688
7.
In Vitro and In Vivo Correlation of Hepatic Fraction of Metabolism by P450 in Dogs.
J Pharm Sci;
108(2): 1017-1026, 2019 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30244007
8.
Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy.
Mol Cancer Ther;
18(12): 2207-2219, 2019 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31530649
9.
Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene.
Cancer Discov;
9(2): 248-263, 2019 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30373917
10.
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Sci Rep;
8(1): 15458, 2018 10 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30337562
11.
Pharmacokinetic comparisons of tail-bleeding with cannula- or retro-orbital bleeding techniques in rats using six marketed drugs.
J Pharmacol Toxicol Methods;
56(2): 256-64, 2007.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17618130
12.
Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration.
Mol Cancer Ther;
16(12): 2677-2688, 2017 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29054982
13.
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
J Med Chem;
60(23): 9599-9616, 2017 12 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29072452
14.
Identification of LY2510924, a novel cyclic peptide CXCR4 antagonist that exhibits antitumor activities in solid tumor and breast cancer metastatic models.
Mol Cancer Ther;
14(2): 480-90, 2015 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25504752
15.
Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.
J Med Chem;
45(8): 1697-711, 2002 Apr 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11931625
16.
Proteomic analysis of rat liver phosphoproteins after treatment with protein kinase inhibitor H89 (N-(2-[p-bromocinnamylamino-]ethyl)-5-isoquinolinesulfonamide).
J Pharmacol Exp Ther;
318(2): 589-95, 2006 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16687476
17.
Modeling of relationships between pharmacokinetics and blockade of agonist-induced elevation of intraurethral pressure and mean arterial pressure in conscious dogs treated with alpha(1)-adrenoceptor antagonists.
J Pharmacol Exp Ther;
300(2): 495-504, 2002 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11805209
18.
Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.
Bioorg Med Chem Lett;
12(3): 465-9, 2002 Feb 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11814821
19.
Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: a novel fungicidal lipopeptide-(I).
Bioorg Med Chem Lett;
13(3): 489-93, 2003 Feb 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12565957