Detalhe da pesquisa
1.
The sialidase NEU1 directly interacts with the juxtamembranous segment of the cytoplasmic domain of mucin-1 to inhibit downstream PI3K-Akt signaling.
J Biol Chem;
297(5): 101337, 2021 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34688655
2.
Therapeutic Effect of Neuraminidase-1-Selective Inhibition in Mouse Models of Bleomycin-Induced Pulmonary Inflammation and Fibrosis.
J Pharmacol Exp Ther;
376(1): 136-146, 2021 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33139318
3.
Neuraminidase 1-mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection.
J Biol Chem;
294(2): 662-678, 2019 01 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30429216
4.
The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo.
Glycobiology;
26(8): 834-49, 2016 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27226251
5.
Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis.
Am J Physiol Lung Cell Mol Physiol;
310(10): L940-54, 2016 05 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26993524
6.
TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.
J Biol Chem;
287(20): 16132-45, 2012 May 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22447928
7.
Altered sialidase expression in human myeloid cells undergoing apoptosis and differentiation.
Sci Rep;
12(1): 14173, 2022 08 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35986080
8.
Diverse injurious stimuli reduce protein tyrosine phosphatase-µ expression and enhance epidermal growth factor receptor signaling in human airway epithelia.
Exp Lung Res;
37(6): 327-43, 2011 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21649524
9.
MUC1 ectodomain is a flagellin-targeting decoy receptor and biomarker operative during Pseudomonas aeruginosa lung infection.
Sci Rep;
11(1): 22725, 2021 11 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34811449
10.
As human lung microvascular endothelia achieve confluence, src family kinases are activated, and tyrosine-phosphorylated p120 catenin physically couples NEU1 sialidase to CD31.
Cell Signal;
35: 1-15, 2017 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28343945