Propyl-phthalimide Cyclotricatechylene-Based Chemosensor for Sulfosulfuron Detection: Hybrid Computational and Experimental Approach.

The detection of trace amounts of sulfosulfuron, a pesticide of increasing importance, has become a pressing issue, prompting the development of effective chemosensors. In this study, we functionalized cyclotricatechylene (CTC) with propyl-phthalimide due to the presence of electronegative oxygen and nitrogen binding sites. Our optimized ligand displayed the highest docking score with sulfosulfuron, and experimental studies confirmed a significant fluorescence enhancement upon its interaction with sulfosulfuron. To gain a deeper understanding of the binding mechanism, we introduced density functional theory (DFT) studies. We carried out binding constant, Job's plot, and limit of detection (LOD) calculations to establish the effectiveness of our chemosensor as a selective detector for sulfosulfuron. These findings demonstrate the potential of our chemosensor for future applications in the field of pesticide detection.

Analysis of a Small Group of Stakeholders Regarding Advancing Health Technology Assessment in India.

OBJECTIVES: This study aimed to explore and understand the perspectives of a small group of stakeholders involved in health technology assessment (HTA) for evidence-informed decision making on policy in the Indian health system. METHODS: Semi-structured interviews were conducted in April-June 2013 with policymakers, academicians, industry experts, and community representatives in India to understand their knowledge of, position regarding, and interest in HTA. A semi-structured questionnaire was designed on the basis of a World Health Organization framework for evidence-informed health care policymaking. RESULTS: Seven key informant interviews were conducted to represent the various stakeholders. Although there is a good understanding of HTA among the national-level policymakers, academicians, civil society representatives, and industry experts, there is lack of knowledge about the subject among policymakers at the lower level. There is a positive perception about producing and using HTA for decision making among all the stakeholders interviewed. Nevertheless, at the national level, institutions prefer to treat the use of HTA evidence with caution because the capacity for adopting evidence-based tools in the health system is very limited. CONCLUSIONS: This small-size stakeholder analysis suggests a mixed response in implementing HTA in India. There are, however, factors involved in implementing such tools that can be dealt with using various approaches. Finally, there is a positive view on the national level toward pushing the HTA agenda forward to improve the decision-making process in health care.