Identification of factors contributing to the development of postoperative delirium in geriatric patients with hip fractures- A prospective study.

Introduction: Geriatric hip fractures are a major cause of concern globally and often a frequent reason for morbidity and mortality. Postoperative delirium (POD) is a frequent but often under-diagnosed complication, especially after a major hip surgery. Some of the factors that have been associated with POD are diabetes, high American Society of Anesthesiologists (ASA) grading, electrolyte imbalance, and blood pressure fluctuations. Malnutrition as a risk factor is only recently being recognized. Although there are many possible risk factors reported, they are quite conflicting and not very clear. Therefore, we have attempted to conduct this study to identify the potential risk factors for the development of POD in patients with hip fractures. Materials and Methods: A prospective observational study was performed on 110 geriatric hip fracture patients admitted to tertiary health care in South India. Data regarding preoperative blood investigations, ASA grading, hypertension and diabetes status, MNA (mini nutritional assessments) status, serum albumin, and serum electrolytes values were recorded. The Confusion Assessment Method tool (CAM) was used to diagnose delirium in the postoperative period. Statistical analysis was done for various factors influencing the occurrence of POD. Results: Among the total of 110 cases of geriatric hip fractures patients, 44.5% of the patients developed postoperative delirium. Advancing age, hypoalbuminemia, malnourishment, and uncontrolled diabetes played an important role to the development of post operative delirium in patients with hip fractures. Conclusion: Advancing age, hypoalbuminemia, malnourishment, and uncontrolled diabetes are strong predictors for the development of postoperative delirium in geriatric hip fracture patients. Since age is a non-modifiable risk factor, interventional strategies aimed at correcting modifiable risk factors like nutrition, serum albumin levels, and diabetes control play an important part in preventing delirium in the postoperative period in elderly hip fracture patients.MeSH terms: Hip Fractures, Postoperative Complication, Delirium, Nutrition Assessment, Serum Albumin.

A Comparative Study of Squash Smear Cytology Diagnosis and Radiological Diagnosis with Histopathology in Central Nervous System Lesions.

Background: Space occupying lesions (SOLs) of central nervous system (CNS) constitutes important cause of neurological morbidity and mortality. Squash cytology is technically a simple and rapid intraoperative diagnostic tool. Radiology is supportive of histopathological diagnosis. Objectives: To enumerate the histopathological patterns of various central nervous system (CNS) lesions, to correlate cytopathological diagnosis with histopathological diagnosis, and to correlate radiological diagnosis with histopathological diagnosis. Materials and Methods: It was a retrospective study of CNS lesion cases from January 2015 to August 2018. Cytological-histopathological concordance and radiological-histopathological concordance were calculated. Chi-square test was the statistical tool used for statistical analysis. Results: Histopathological diagnosis of 50 cases included neoplastic lesions (42 cases [84%]) and non-neoplastic lesions (8 cases [16%]). Correct diagnosis was achieved by squash cytology in 36 cases (72%) and radiological diagnosis in 25 cases (50%) by complete concordance. However, diagnostic accuracy of squash and radiology improved considerably by 90% and 76%, respectively, after applying partial concordance criteria. For the detection of neoplastic lesions, squash cytology had 98% and radiology had 80% diagnostic efficacy. Conclusion: Preoperative radiological investigation and intraoperative squash smear cytology are complementary to each other. A multidisciplinary approach is necessary for the management of patients.

Is Platelet-rich Plasma Injection more Effective than Steroid Injection in the Treatment of Chronic Plantar Fasciitis in Achieving Long-term Relief?

Introduction: Plantar fasciitis is characterised by pain in the heel, which is aggravated on weight bearing after prolonged rest. Many modalities of treatment are commonly used in the management of plantar fasciitis including steroid injection. Many studies show that steroid injection provides pain relief in the short term but not long lasting. Recent reports show autologous platelet-rich plasma (PRP) injection promotes healing, resulting in better pain relief in the short as well as long term. The present study was undertaken to compare the effects of local injection of platelet-rich plasma and Corticosteroid in the treatment of chronic plantar fasciitis. Materials and methods: Patients with the clinical diagnosis of chronic plantar fasciitis (heel pain of more than six weeks) after failed conservative treatment and plantar fascia thickness more than 4mm were included in the study. Patients with previous surgery for plantar fasciitis, active bilateral plantar fasciitis, vascular insufficiency or neuropathy related to heel pain, hypothyroidism and diabetes mellitus were excluded from the study. In this prospective double-blind study, 60 patients who fulfilled the criteria were divided randomly into two groups. Patients in Group A received PRP injection and those in Group B received steroid injection. Patients were assessed with visual analog scale (VAS) and American Orthopedic Foot and Ankle Society (AOFAS) score. Assessment was done before injection, at six weeks, three months and six months follow-up after injection. Plantar fascia thickness was assessed before the intervention and six months after treatment using sonography. Results: Mean VAS in Group A decreased from 7.14 before injection to 1.41 after injection and in Group B decreased from 7.21 before injection to 1.93 after injection, at final follow-up. Mean AOFAS score in Group A improved from 54 to 90.03 and in Group B from 55.63 to 74.67 at six months' follow-up. The improvements observed in VAS and AOFAS were statistically significant. At the end of six months' follow-up, plantar fascia thickness had reduced in both groups (5.78mm to 3.35mm in Group A and 5.6 to 3.75 in Group B) and the difference was statistically significant. Conclusion: Local injection of platelet-rich plasma is an effective treatment option for chronic plantar fasciitis when compared with steroid injection with long lasting beneficial effect.

Assessment of anterior segment parameters under photopic and scotopic conditions in Indian eyes using anterior segment optical coherence tomography.

PURPOSE: To compare the anterior segment parameters in photopic and scotopic conditions using anterior segment optical coherence tomography (AS OCT) in Indian eyes. MATERIALS AND METHODS: One hundred eyes of 100 normal subjects of both sexes, aged 19 to 76 years, underwent anterior segment evaluation by AS OCT (Visante OCT). Central corneal thickness (CCT), central anterior chamber depth (ACD), pupil diameter (PD) and the temporal and nasal peripheral irido-corneal angles were assessed in photopic and scotopic conditions. These anterior segment parameters were stratified for age, sex and refractive error. RESULTS: Mean values of the parameters measured in photopic and scotopic conditions respectively were as follows: ACD (mm) 2.88 +/- 0.32, 2.89 +/- 0.32 (P = 0.10); nasal angle (degrees) 28.80 +/- 5.91, 22.28 +/- 7.50 (P < 0.001); temporal angle (degrees) 29.95 +/- 6.74, 22.82 +/- 8.43 (P < 0.001); pupil diameter (mm) 4.08 +/- 0.91, 4.68 +/- 0.92 (P < 0.001); CCT (microm) 519 +/- 33.88, 519 +/- 33.88. CONCLUSIONS: There was no significant difference in the ACD in photopic and scotopic conditions. While the nasal and temporal angles showed a significant decrease, the pupil diameter showed a significant increase in scotopic conditions. Mean central ACD decreased with age and was shallower in females than in males. It was highest in myopes and lowest in hypermetropes. CCT was not influenced by photopic and scotopic conditions.

Optic disc topography of normal Indian eyes: an assessment using optical coherence tomography.

PURPOSE: To study the optic disc topographic measurements of normal Indian eyes using optical coherence tomography (OCT). MATERIALS AND METHODS: One hundred and fifty eyes selected randomly from 150 normal Indian subjects of both sex and various age groups underwent optic disc imaging with the OCT using the fast optic disc protocol. RESULTS: Mean +/- standard deviation of the optic disc topographic measurements were: disc area 2.63 +/- 0.55 mm 2 , cup area 0.87 +/- 0.45 mm 2 , neuroretinal rim area 1.78 +/- 0.55 mm 2 and cup to disc area ratio 0.33 +/- 0.15. There was no significant difference in the measurements between males and females. There was no significant correlation with respect to age and refractive errors ranging from -5.0 to +3.0 diopters of spherical equivalent. CONCLUSION: Our study provides a normative database for the various optic disc topographic measurements and its variations with age, sex and refractive error in normal Indian eyes using OCT.

Multizone photorefractive keratectomy for myopia of 8 to 23 diopters.

Multizone photorefractive keratectomy (PRK) was performed on 124 eyes of 69 patients for the treatment of high myopia using 4.5 mm, 5.0 mm, and 6.0 mm diameter ablation zones. Preoperative spherical equivalent refractions ranged from -8.00 diopters (D) to -22.5 D (mean +/- SD, -12.3 +/- 3.9 D). Mean attempted ablation depth was 109.5 +/- 37.8. Follow up ranged from 6 to 9 months. An uncorrected visual acuity of 20/60 or better was achieved in 63% of eyes and 20/40 or better in 48% of eyes. Sixty-seven percent of eyes achieved their pretreatment spectacle corrected visual acuity or were within two Snellen lines of it at 6 months postop. Subepithelial haze was mild in 23% of eyes and moderate in another 34% of eyes. This cleared without a trace in almost all of these eyes within 6 months. Twenty-five percent of the eyes had dense scars and required reablation.

Increasing the number of photorefractive keratectomy procedures from a single excimer laser gas fill.

Excimer laser ablative procedures are an expensive proposition for both the patient and the user. The high capital expenditure and the cost of consumables, notably the argon-fluoride gas, makes it imperative to achieve maximum utilization in terms of number of cases treated per fill of gas. This is particularly true in countries like India. The maximum number of cases can be treated by understanding not only the limitations of each fill of gas, but by proper patient scheduling and modifications to the treatment protocol. This paper outlines our modified protocol and the patient scheduling software that we developed to meet these criteria.

Intraocular magnet of Parel.

The intraocular magnet (IOM) is a new device based on permanent magnetism providing controlled energy for removal of magnetic intraocular foreign bodies. Its use is reported in 11 cases.

Gas gangrene infection of the eyes and orbits.

The literature on Clostridium perfringens infections is reviewed up to 1983. An additional case is reported with bilateral clostridial infections of the eye and orbit. One eye followed the classical course of relentless panophthalmitis, amaurosis, and orbital cellulitis ending in enucleation. The second eye contained intracameral mud and gas bubbles that were removed by vitrectomy instrumentation. Subsequent removal of the toxic cataract resulted in a final aided visual acuity of 6/18, N8. This is the third report of a retained globe, and we believe the only known case where the patient was left with useful vision.