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1.
Int J Paleopathol ; 40: 33-40, 2023 03.
Artigo em Inglês | MEDLINE | ID: mdl-36455429

RESUMO

OBJECTIVE: To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts. MATERIALS: A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod sýpkou (Czech Republic), radio-carbon dated to AD 492-530. METHODS: Morphological and metric analyses. RESULTS: Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calvé-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases. CONCLUSIONS: The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia. SIGNIFICANCE: This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice. LIMITATIONS: The final diagnosis is limited by the lack of genetic analysis. SUGGESTION FOR THE FUTURE RESEARCH: Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.


Assuntos
Acondroplasia , Doença de Legg-Calve-Perthes , Osteocondrodisplasias , Masculino , Humanos , Adulto , Pessoa de Meia-Idade , República Tcheca , Cemitérios
2.
Int J Paleopathol ; 24: 185-196, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30497062

RESUMO

The skeletal remains of the young female (20-24 years) from Grave JP/106, discovered in the Southern Suburb of the Breclav - Pohansko Stronghold (Early Middle Ages, 9th century-beginning of the 10th century, present day Czech Republic) display several noteworthy pathologies. The first is deformation of the mandible, which was most probably caused by a fracture of the ramus in combination with a subcondylar fracture. The spine of this young woman also exhibits a probable traumatic injury of the cervical spine in combination with a slowly growing structure situated inside the spinal canal, which caused deformation centered upon C7. The cervical and thoracic spine together with internal surfaces of several ribs exhibit infectious changes of advanced stage, in all likelihood of tuberculous origin, but osteomyelitis cannot be excluded. Histological analysis of the new bone formation in the ribs confirmed infectious origin, as does Micro CT of C5 and C6. Analyses conducted by two different departments with different methods (PCR amplification of 123 bp long section from IS6110 and Next Generation shotgun sequencing) failed to identify DNA of Mycobacterium tuberculosis from the first rib.


Assuntos
Vértebras Cervicais/patologia , Fraturas Ósseas/patologia , Traumatismos da Coluna Vertebral/história , Tuberculose/patologia , Ferimentos e Lesões/patologia , Doença Crônica , República Tcheca , Feminino , Fraturas Ósseas/história , História Medieval , Humanos , Pescoço/patologia , Tuberculose/diagnóstico , Tuberculose/história , Ferimentos e Lesões/diagnóstico , Ferimentos e Lesões/história
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