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1.
Aging (Albany NY) ; 14(8): 3446-3463, 2022 04 22.
Artigo em Inglês | MEDLINE | ID: mdl-35452413

RESUMO

Lymphoma is accompanied by the impairment of multiple immune functions. Cytokines play an important role in a variety of immune-related functions and affect the tumor microenvironment. However, the exact regulatory mechanisms between them remain unclear. This study aimed to explore the cytokines expression and function in Hodgkin's lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), and mantle cell lymphoma (MCL). We performed a transcriptome integration analysis of 14 lymphoma datasets including 240 Hodgkin's lymphoma, 891 diffuse large B-cell lymphoma, 216 mantle cell lymphoma, and 64 health samples. The results showed that multiple immune functions and signal pathway damage were shared by all three types of lymphoma, and these functions were related to cytokines. Furthermore, through co-expression network and functional interaction network analysis, we identified CXCL14 as a key regulator and it affects cell chemotaxis and migration functions. The functional experiment showed that CXCL14 knockdown inhibited cell migration in MCL cell lines. This study suggested that high expression of CXCL14 may aggravate MCL via promoting cell migration. Our findings provide novel insights into the biology of this disease and would be helpful for the pathogenesis study and drug discovery of lymphomas.


Assuntos
Doença de Hodgkin , Linfoma Difuso de Grandes Células B , Linfoma de Célula do Manto , Movimento Celular/genética , Quimiocinas CXC/genética , Citocinas , Humanos , Linfoma Difuso de Grandes Células B/patologia , Linfoma de Célula do Manto/genética , Microambiente Tumoral/genética
2.
Carbohydr Polym ; 256: 117497, 2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33483024

RESUMO

In order to achieve high loading and efficient delivery of curcumin, phenylboronic acid-conjugated chitosan nanoparticles were prepared by a simple desolvation method. These nanoparticles exhibited a regular spherical shape with the average size about 200-230 nm and narrow size distribution, which were kinetically stable under physiological condition. Due to boronate ester formation between curcumin and phenylboronic acid groups in the nanoparticles, and the hydrogen bonding interactions between curcumin and nanocarriers, curcumin was successfully loaded into the nanoparticles with high drug loading content. These curcumin-loaded nanoparticles showed pH and reactive oxygen species (ROS)-triggered drug release behavior. In vitro cell experiments revealed that the blank nanoparticles were completely nontoxic to cultured cells, and the curcumin-loaded nanoparticles exhibited efficient antitumor efficiency against cancer cells. Moreover, the drug-loaded nanoparticles performed an enhanced growth inhibition in three-dimensional multicellular tumor spheroids. Thus, these nanocarriers would be a promising candidate for curcumin delivery in tumor treatment.


Assuntos
Ácidos Borônicos/química , Quitosana/química , Curcumina/química , Portadores de Fármacos , Nanopartículas Metálicas/química , Materiais Biocompatíveis , Proliferação de Células , Sobrevivência Celular , Liberação Controlada de Fármacos , Células Hep G2 , Humanos , Concentração de Íons de Hidrogênio , Cinética , Espectroscopia de Ressonância Magnética , Nanopartículas/química , Nanotecnologia/métodos , Espécies Reativas de Oxigênio , Esferoides Celulares
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