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Differentiated cells telomere length is an indicator of senescence or lifespan; however, in peripheral blood leukocytes the relative shortening of the telomere has been considered as a biological marker of aging, and lengthening telomere as an associated risk to cancer. Individual's age, type of tissue, lifestyle, and environmental factors make telomere length variable. The presence of environmental carcinogens such as arsenic (As) influence as causal agents of these alterations, the main modes of action for As described are oxidative stress, reduction in DNA repair capacity, overexpression of genes, alteration of telomerase activity, and damage to telomeres. The telomeres of leukocytes resulting a finite capacity of replication due to the low or no activity of the telomerase enzyme, therefore, elongation telomere in this kind of cells is a potential biological marker associated with the development of chronic diseases and carcinogenesis.
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CONTEXT: Lipolysis is one of the most important pathways for energy management, its control in the adipose tissue (AT) is a potential therapeutic target for metabolic diseases. Adenosine Mono Phosphate-activated Protein Kinase (AMPK) is a key regulatory enzyme in lipids metabolism and a potential target for diabetes and obesity treatment. OBJECTIVE: The aim of this work is to analyse the existing information on the relationship of AMPK and lipolysis in the AT. METHODS: A thorough search of bibliography was performed in the databases Scopus and Web of Knowledge using the terms lipolysis, adipose tissue, and AMPK, the unrelated publications were excluded, and the documents were analysed. RESULTS: Sixty-three works were found and classified in 3 categories: inhibitory effects, stimulatory effect, and diverse relationships; remarkably, the newest researches support an upregulating relationship of AMPK over lipolysis. CONCLUSION: The most probable reality is that the relationship AMPK-lipolysis depends on the experimental conditions.
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Proteínas Quinases Ativadas por AMP , Lipólise , Proteínas Quinases Ativadas por AMP/metabolismo , Monofosfato de Adenosina/metabolismo , Tecido Adiposo/metabolismo , FosforilaçãoRESUMO
RESUMEN: Estudios recientes han demostrado que los compuestos activos presentes en extractos de C. chayamansa, E. prostrata y J. dioica tienen propiedades antioxidantes. Los resultados obtenidos en nuestro estudio fueron compuestos fenólicos solubles mostraron en C. chayamansa 6,34, E. prostrata 10,67, J. dioica 1,83 mg equiv de ácido gálico/gm BS respectivamente. Los antioxidantes solubles en agua por el método ABTS fueron para C. chayamansa 5.9, E. prostrata 12.7 y para J. dioica 2.5 mM equiv. de trolox/gr BS. Los resultados histopatológicos muestran una mejoría en los tejidos tratados con los extractos después de la inducción a hiperglicemia.
SUMMARY: Recent studies have shown that the active compounds present in extracts of C. chayamansa, E. prostrata and J. dioica have antioxidant properties. The results obtained in our study were soluble phenolic compounds showed in C. chayamansa 6.34, E. prostrata 10.67, J. dioica 1.83 mg equiv of gallic acid/gm BS respectively. The antioxidants soluble in water by the ABTS method were for C. chayamansa 5.9, E. prostrata 12.7 and for J. dioica 2.5 mM equiv. of trolox/gr BS. The histopathological results show an improvement in the tissues treated with the extracts after the induction to hyperglycemia.
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Animais , Ratos , Extratos Vegetais/administração & dosagem , Euphorbia/química , Jatropha/química , Hiperglicemia/tratamento farmacológico , Antioxidantes/administração & dosagem , Fenóis/análise , Flavonoides/análise , Extratos Vegetais/química , Ratos Wistar , Compostos Fenólicos , Hiperglicemia/induzido quimicamente , Rim/efeitos dos fármacos , Fígado/efeitos dos fármacos , Antioxidantes/químicaRESUMO
El Theracal TM LC es un cemento silicato de calcio (Ca) modificado con resina (SMCR) que ha demostrado ser un material ideal para el tratamiento dentino-pulpar por su alta tasa de formación de calcio. Los biomateriales por su contenido de Ca tienden a tener un aumento en su biodisponibilidad, estimulando la formación del puente dentario atreves de las células involucradas en la formación de tejidos mineralizados, promoviendo la diferenciación de fibroblastos en odontoblastos y aumentando la actividad de la enzima pirofostasa responsable en la mineralización de la dentina. El presente estudio con el objetivo de evaluar la respuesta inflamatoria a Theracal TM LC subcutáneamente en ratas Wistar. Fueron usados seis ratas cepa Wistar en las cuales se realizaron cuatro bolsillos quirúrgicos subcutáneos. Cada uno de estos bolsillos se determinó como cuadrante distinto, conteniendo los siguientes implantes: 1 Theracal TM LC en tubo polietileno, 2 tubo de polietileno, 3 Theracal TM LC directo y 4 como control. Las muestras histológicas se procesaron y se evaluaron distintos tipos celulares mediante conteo a microscopio de luz a 100X utilizando las tinciones H&E y AT pH 2.3. Los resultados mostraron que existen diferencias significativas en todos los tipos celulares observados durante los diferentes tiempos de exposición. Las diferencias en los tipos celulares observados podrían ser debido al tiempo de exposición al Theracal TM LC, al tubo polietileno y a ambos. El tejido evaluado del implante del tubo polietileno y al tubo polietileno con Theracal TM LC, presentan mayor respuesta inflamatoria, a diferencia en el tejido implantado con Theracal TM LC directamente.
TheraCalTM LC is a resin-modified calcium silicate (Ca) resin (SMCR) that has proven to be an ideal material for dentin-pulp treatment due to its high rate of calcium formation. Biomaterials due to their Ca content tend to have an increase in their bioavailability, stimulating the formation of the dental bridge through the cells involved in the formation of mineralized tissues, promoting the differentiation of fibroblasts in odontoblasts and increasing the activity of the pyrophosphate enzyme responsible in dentin mineralization. The present study aimed to evaluate the inflammatory response to TheracalTM LC subcutaneously in Wistar rats. Six Wistar strain rats were used in which four subcutaneous surgical pockets were made. Each of these pockets was determined as a different quadrant, containing the following implants: 1 TheracalTM LC in polyethylene tube, 2 polyethylene tubes, 3 TheracalTM LC direct and 4 as control. The histological samples were processed, and different cell types were evaluated by light microscopy at 100X using the H&E and AT pH 2.3 stains. The results showed that there are significant differences in all cell types observed during the different exposure times. The differences in the cell types observed could be due to the exposure time to TheracalTM LC, to the polyethylene tube and to both. The evaluated tissue of the polyethylene tube implant and the polyethylene tube with TheracalTM LC present a greater inflammatory response, unlike in the tissue implanted with TheracalTM LC directly.
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Animais , Ratos , Compostos de Cálcio/farmacologia , Resinas Compostas/farmacologia , Tela Subcutânea/efeitos dos fármacos , Inflamação , Materiais Biocompatíveis/farmacologia , Ratos Wistar , SilicatosRESUMO
Introducción: el estado hipertensivo del embarazo es uno de los problemas obstétricos no resueltos más importante. El embarazo puede inducir elevación tensional y daño renal específico. Se han realizado algunos estudios que describen los cambios de la presión arterial durante todo el embarazo. En países donde el control prenatal no es adecuado, la preeclampsia provoca entre 40 y 80 por ciento de las muertes maternas. Se estima un total de 50 000 muertes por año. Objetivo: evaluar cómo se presenta la evolución de la presión arterial en el puerperio inmediato en pacientes con enfermedad hipertensiva inducida por el embarazo, sometidas a procedimiento de curetaje. Métodos: es un estudio comparativo con un grupo de intervención y un grupo control en el Hospital Universitario Dr. Joaquín del Valle Sánchez, Torreón. Coahuila, México. La intervención consistió en la realización del procedimiento de curetaje transcesárea en las pacientes con enfermedad hipertensiva inducida por el embarazo. Las mediciones principales fueron: el análisis de expediente clínico, perfil bioquímico completo, cifras tensionales. Resultado: la mayoría de las pacientes que acuden al Servicio de Ginecología y Obstetricia son adolescentes entre 14 y 20 años. Hubo una mejora significativa en la presión arterial sistólica a las 8 y 16 h, y una disminución a las 24 h de la presión sistólica y diastólica en pacientes sometidas al procedimiento de curetaje. Conclusiones: el uso del procedimiento de curetaje transcesárea en pacientes con enfermedad hipertensiva inducida por el embarazo disminuye considerablemente la presión arterial. Se sugiere el uso de este procedimiento en pacientes sometidas a cesárea en el Hospital Universitario Dr. Joaquín del Valle Sánchez y otros centros de salud(AU)
Introduction: Hypertensive pregnancy status is one of the obstetrical most important unsolved problems. Pregnancy can induce specific tensional elevation and kidney damage. There have been some studies describing changes in blood pressure throughout pregnancy. In countries where prenatal care is not adequate, preeclampsia causes 40 and 80 percent of maternal deaths. 50 000 deaths per year are estimated. Objective: Evaluate how the evolution of blood pressure in the immediate postpartum period in patients undergoing curettage procedure is presented due to pregnancy-induced hypertensive disease. Methods: A comparative study with an intervention group and a control group was conductedat Dr. Sanchez Joaquin Valley University Hospital, in Torreon, Coahuila, Mexico. The intervention consisted of carrying out the process of trans-cesarean curettage in patients with pregnancy-induced hypertensive disease. The main readings were the analysis of medical records, complete biochemical profile, and pressure figures. Result: Most patients who come to the service of Gynecology and Obstetrics are teenagers 14-20 years. There was significant improvement in systolic blood pressure at 8 and 16 h, and decreased to 24 in systolic and diastolic blood pressure in patients undergoing the procedure of curettage. Conclusions: The use of curettage procedure after cesarean section in patients with hypertensive disease induced by pregnancy significantly lowers blood pressure. The use of this procedure is suggested in patients undergoing cesarean section at suggested Dr. Joaquín del Valle Sánchez University Hospital and other health centers(AU)