1.
Chem Asian J
; 8(6): 1105-9, 2013 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23509056
RESUMO
The pain ends here: A novel synthetic strategy for the construction of (±)-morphine ringsâ B and E was developed, in which SmI2 -promoted reductive coupling/desulfurization and tandem alcoholysis/oxa-Michael addition featured as the key steps for the assembly of the C9-C14 and C5-O bonds, respectively. Asymmetric tandem alcoholysis/oxa-Michael addition was also feasible for the enantiocontrolled synthesis of morphine.