RESUMO
Three new polyketides, chaetochromones A - C (1 - 3), together with a chromone (4), were isolated from the ethyl acetate extract of mangrove-derived fungus Phomopsis sp. SCSIO 41006. Their structures were elucidated by means of spectroscopic techniques (UV, IR, MS, 1D- and 2D-NMR). The absolute configurations of the new compounds were established by CD data.
Assuntos
Fungos/metabolismo , Policetídeos/química , Rhizophoraceae/microbiologia , Células A549 , Anti-Infecciosos/química , Anti-Infecciosos/isolamento & purificação , Anti-Infecciosos/farmacologia , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Cromonas/química , Cromonas/isolamento & purificação , Cromonas/farmacologia , Dicroísmo Circular , Fungos/classificação , Fungos/isolamento & purificação , Humanos , Células K562 , Espectroscopia de Ressonância Magnética , Conformação Molecular , Filogenia , Policetídeos/isolamento & purificação , Policetídeos/farmacologia , Policetídeos/toxicidade , Salmonella typhi/efeitos dos fármacos , Espectrometria de Massas por Ionização por Electrospray , Espectrofotometria Ultravioleta , Staphylococcus aureus/efeitos dos fármacosRESUMO
Two new polyketides, aspergchromones A (1) and B (2), together with five known compounds, secalonic acid D (3), noreugenin (4), (3S)-5-hydroxymellein (5), (4S)-6-hydroxyisosclerone (6), and (-)-regiolone (7), were isolated from the ethyl acetate extract of marine sponge-derived fungus Aspergillus sp. SCSIO XWS03F03. Their structures were elucidated by means of spectroscopic techniques (1D and 2D NMR, MS, UV, and IR). The absolute configurations of the new compounds were established by ECD calculations. Compound 3 showed moderate antimicrobial activity.
Assuntos
Aspergillus/química , Policetídeos/isolamento & purificação , Poríferos/microbiologia , Xantonas/isolamento & purificação , Animais , Biologia Marinha , Testes de Sensibilidade Microbiana , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Policetídeos/química , Xantonas/químicaRESUMO
A new alkaloid named N-(3-aminopropyl)subergorgamide (1), along with nine known nitrogen-containing compounds (2-10), was isolated from the organic extract of gorgonian Paraplexaura sp. collected from Zhanjiang in Naozhou Island, South China Sea. Their structures were established by detailed MS and NMR spectroscopic analyses, as well as by comparison with literature data.
Assuntos
Alcaloides/isolamento & purificação , Antozoários/química , Alcaloides/química , Animais , China , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Oceanos e MaresRESUMO
Two new phenyl derivatives (1 and 3), along with two new natural products (4 and 5), and three known compounds (2, 6 and 7), were isolated from an endophytic fungus Botryosphaeria sp. SCSIO KcF6. The structures of these compounds 1-7 were elucidated by the extensive 1D and 2D-NMR and HRESIMS Data analysis, and compared with those of reported data. The absolute configuration of the compounds 1 and 3 were assigned by optical rotation and CD data. The isolated compounds were evaluated for their cytotoxic, anti-inflammatory (COX-2) and antimicrobial activities. Compound 3 exhibited a specific COX-2 inhibitory activity with the IC50 value of 1.12 µM.
Assuntos
Ascomicetos/química , Produtos Biológicos/química , Produtos Biológicos/farmacologia , Avaliação Pré-Clínica de Medicamentos/métodos , Rhizophoraceae/microbiologia , Sesquiterpenos/química , Anti-Infecciosos/química , Anti-Infecciosos/farmacologia , Anti-Inflamatórios não Esteroides/química , Anti-Inflamatórios não Esteroides/farmacologia , Antineoplásicos/química , Antineoplásicos/farmacologia , Ascomicetos/fisiologia , Produtos Biológicos/isolamento & purificação , Linhagem Celular Tumoral/efeitos dos fármacos , Inibidores de Ciclo-Oxigenase 2/química , Inibidores de Ciclo-Oxigenase 2/farmacologia , Endófitos/química , Fermentação , Humanos , Concentração Inibidora 50 , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Sesquiterpenos/farmacologia , Áreas AlagadasRESUMO
A new citromycetin analogue, ascomycotin A (1), together with eight known compounds, wortmannilactone E (2), orcinol (3), orsellinic acid (4), isosclerone (5), (3R,4S)-( - )-4-hydroxymellein (6), diorcinol (7), chaetocyclinone B (8) and 2,5-dimethoxy-3,6-di(p-methoxypheny1)-1,4-benzoquinone (9), was isolated from the fungal strain Ascomycota sp. Ind19F07, which was isolated from the deep sea sediment of the Indian Ocean. The structures of the compounds were established by spectroscopic data including 1D and 2D NMR and HR-ESI-MS. Compounds (1-9) were evaluated for antibacterial activity.