Detalhe da pesquisa
1.
Mg2+-dependent conformational rearrangements of CRISPR-Cas12a R-loop complex are mandatory for complete double-stranded DNA cleavage.
Proc Natl Acad Sci U S A;
118(49)2021 12 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34853172
2.
Quantitative assessment of engineered Cas9 variants for target specificity enhancement by single-molecule reaction pathway analysis.
Nucleic Acids Res;
49(19): 11312-11322, 2021 11 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34554247
3.
Visual function restoration in a mouse model of Leber congenital amaurosis via therapeutic base editing.
Mol Ther Nucleic Acids;
31: 16-27, 2023 Mar 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36589710
4.
Exploring the dynamic nature of divalent metal ions involved in DNA cleavage by CRISPR-Cas12a.
Chem Commun (Camb);
58(12): 1978-1981, 2022 Feb 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35045150
5.
High expression of uracil DNA glycosylase determines C to T substitution in human pluripotent stem cells.
Mol Ther Nucleic Acids;
27: 175-183, 2022 Mar 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34976436
6.
High-purity production and precise editing of DNA base editing ribonucleoproteins.
Sci Adv;
7(35)2021 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34452911