Detalhe da pesquisa
1.
Composition and Conformation of Hetero- versus Homo-Fluorinated Triazolamers Influence their Activity on Islet Amyloid Polypeptide Aggregation.
Chemistry;
30(28): e202303887, 2024 May 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38478740
2.
Real-Time BODIPY-Binding Assay To Screen Inhibitors of the Early Oligomerization Process of Aß1-42 Peptide.
Chembiochem;
21(8): 1129-1135, 2020 04 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31702868
3.
Helical γ-Peptide Foldamers as Dual Inhibitors of Amyloid-ß Peptide and Islet Amyloid Polypeptide Oligomerization and Fibrillization.
Chemistry;
26(64): 14612-14622, 2020 Nov 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32542806
4.
Evidence for different in vitro oligomerization behaviors of synthetic hIAPP obtained from different sources.
Anal Bioanal Chem;
412(13): 3103-3111, 2020 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32211924
5.
The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic ß-strands.
Beilstein J Org Chem;
13: 2842-2853, 2017.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29564012
6.
An improved capillary electrophoresis method for in vitro monitoring of the challenging early steps of Aß1-42 peptide oligomerization: application to anti-Alzheimer's drug discovery.
Electrophoresis;
35(23): 3302-9, 2014 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25219962
7.
Proteolytically Stable Diaza-Peptide Foldamers Mimic Helical Hot Spots of Protein-Protein Interactions and Act as Natural Chaperones.
J Med Chem;
66(17): 12005-12017, 2023 09 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37632446
8.
New Hybrid Compounds Incorporating Natural Products as Multifunctional Agents against Alzheimer's Disease.
Pharmaceutics;
15(10)2023 Sep 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37896129
9.
Peptidotriazolamers Inhibit Aß(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model.
Chempluschem;
86(6): 840-851, 2021 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33905181
10.
ß-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation.
Front Cell Dev Biol;
9: 729001, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34604227
11.
Synthesis and biological evaluation of cis-locked vinylogous combretastatin-A4 analogues: derivatives with a cyclopropyl-vinyl or a cyclopropyl-amide bridge.
Bioorg Med Chem Lett;
19(5): 1318-22, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19211248
12.
Peptides and peptidomimetics as inhibitors of protein-protein interactions involving ß-sheet secondary structures.
Curr Opin Chem Biol;
52: 157-167, 2019 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31590141
13.
A capillary zone electrophoresis method to investigate the oligomerization of the human Islet Amyloid Polypeptide involved in Type 2 Diabetes.
J Chromatogr A;
1578: 83-90, 2018 Nov 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30327182
14.
Binding Modes of a Glycopeptidomimetic Molecule on Aß Protofibrils: Implication for Its Inhibition Mechanism.
ACS Chem Neurosci;
9(11): 2859-2869, 2018 11 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30025208
15.
Structure-activity relationships of ß-hairpin mimics as modulators of amyloid ß-peptide aggregation.
Eur J Med Chem;
154: 280-293, 2018 Jun 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29807333
16.
In vitro monitoring of amyloid ß-peptide oligomerization by Electrospray differential mobility analysis: An alternative tool to evaluate Alzheimer's disease drug candidates.
Talanta;
165: 84-91, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28153323
17.
Designed Glycopeptidomimetics Disrupt Protein-Protein Interactions Mediating Amyloid ß-Peptide Aggregation and Restore Neuroblastoma Cell Viability.
J Med Chem;
59(5): 2025-40, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26789783
18.
Structure-activity relationships of sugar-based peptidomimetics as modulators of amyloid ß-peptide early oligomerization and fibrillization.
Eur J Med Chem;
86: 752-8, 2014 Oct 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25238173
19.
Non-covalent proteasome inhibitors.
Curr Pharm Des;
19(22): 4115-30, 2013.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23181573
20.
Early effects of combretastatin A4 phosphate assessed by anatomic and carbogen-based functional magnetic resonance imaging on rat bladder tumors implanted in nude mice.
Neoplasia;
8(7): 587-95, 2006 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16867221