Antidepressant Use and Risk of Myocardial Infarction: A Longitudinal Investigation of Sex-Specific Associations in the HUNT Study.

OBJECTIVE: Antidepressants are thought to affect the risk of cardiovascular disease, although the nature of the association is unclear. Men and women have unique cardiovascular risk factors, and sex differences in depression as well as the efficacy of antidepressants are important to consider. We examined whether antidepressant use was associated with risk of having a myocardial infarction (MI) and whether this association was sex-specific. METHODS: Data from The Trøndelag Health Study were used, gathered from a population in Norway ( N = 31,765), collected from 1995 to 2008. These data were combined with the Norwegian Cause of Death Registry and the Norwegian Prescription Database. We performed logistic regression models to examine the association of antidepressant use on risk of having a fatal or nonfatal MI, adjusting for depression, anxiety, diabetes, systolic blood pressure, cholesterol, waist-hip ratio, smoking, age, and sex. Results are presented as odds ratios (ORs) and 95% confidence intervals in parentheses. RESULTS: The results indicated that antidepressant use was associated with a reduced risk of having MI at a later date (OR = 0.49 [0.38-0.64]). Although this association was somewhat stronger for women (OR = 0.46 [0.31-0.68]) compared with men (OR = 0.53 [0.37-0.75]), analysis did not identify a sex-specific association of antidepressant use on MI. Follow-up analyses on different subtypes of antidepressants showed that both selective serotonin reuptake inhibitor and tricyclic antidepressant were associated with a reduced risk of MI. CONCLUSIONS: In this population study, the use of antidepressants was associated with a reduced risk of MI. This association was stronger for women, although we detected no interaction between sex and antidepressant use in terms of reduced risk of MI. Although limitations apply regarding causality, especially concerning a dose-response relationship, the results suggest that antidepressant use might reduce the risk of MI among both men and women.

Police employees working from home during COVID-19 lockdown: Those with higher score on extraversion miss their colleagues more and are more likely to socialize with colleagues outside work.

There is a general opinion that extraverted people suffer more than introverted people in home-office arrangement and the social distancing regulation imposed by the government during the Corona Virus Disease 2019 pandemic (COVID-19). However, scarce research exists concerning how extraversion is associated with satisfaction with home-office arrangement, to what extent individuals miss their colleagues, level of stress, and whether they meet colleagues outside work during lockdown. An online survey was distributed in six police districts in Norway during late May and beginning of June, right before the most stringent measures for constraining risk of COVID-infection was lifted. 1133 out of 1472 reported that their work-situation was home-office, or combined home-office and physical attendance at work. Contrary to what expected, extraversion was not related to satisfaction with home-office arrangement when controlling for other relevant variables (i.e. stress, home-office only, living alone, age, gender and civilian employment). As hypothesized, those with a higher score on extraversion missed their colleagues more than those with low scores. There was a marginal, although significant, negative association between extraversion and stress, and a significant positive relationship between stress and the extent the respondents missed their colleagues during lockdown, independent of extraversion. The results showed a dose-response relationship between extraversion and meeting colleagues outside the work during lockdown.

Mental Health and Work-Related Behaviors in Management of Work Requirements of University Lecturers in Ukraine-An Age Group Comparison.

BACKGROUND: There are only a few national and international studies on the health of third-level professor lecturers at universities and colleges. Work-related diseases are important and relevant for occupational medicine. The aim of the study was to examine the mental health and work-related behavior and experience patterns of Ukrainian university lecturers in age group comparisons. METHODS: Data were collected from 81 Ukrainian university lecturers (General Health Questionnaire (GHQ-12), Questionnaire on Work-Related Behavior and Experience Patterns (AVEM)). The university lecturers were split into 4 age groups. RESULTS: 9.9% of higher education lecturers reported impaired mental health (GHQ-12). In all, 64.8% of the total sample showed AVEM risk patterns. There were differences in age groups (third age group scoring lower than the first age group on the GHQ total score). The first age group had significantly lower opinions of the subjective importance of work on their personal lives compared to the third and fourth age group, while the second age group had significantly lower opinions compared to the fourth age group. All individuals with impaired mental health in GHQ-12 had AVEM risk patterns. CONCLUSIONS: These results offer novel insights into the health of Ukrainian university lecturers. Occupational healthcare practitioners should take them into consideration in order to initiate appropriate interventions.

Mild to moderate partial sleep deprivation is associated with increased impulsivity and decreased positive affect in young adults.

The effects of mild-moderate partial sleep deprivation on affective and cognitive functioning were evaluated in a naturalistic home environment, mimicking short sleep typically caused by demands from work or society. A total of 52 healthy individuals aged 18-35 was included in an 11-day study protocol. Participants slept at home, and sleep patterns were observed using actigraphs and sleep diaries. After maintaining habitual sleep for 7 days, the participants were asked to sleep 2 hours less than their average sleep duration for the last three nights of the study protocol. A not-X continuous performance test was administered at 9 am (± 90 minutes) on days 1, 4, 8 (habitual sleep), 9 and 11 (sleep deprivation). Performance-based measures included response accuracy and speed. Participant-reported measures included how well the participants felt they performed and how exhausted they were from taking the test, as well as positive and negative affect. There was a significant change in reaction time, number of commission errors, subjective performance, subjective exertion, and positive affect across the visits. Specifically, there was a linear decrease in reaction time, performance, and positive affect throughout the study, and a significant quadratic trend for commissions and exertion (first decreasing, then increasing after sleep deprivation). The univariate tests for omissions and negative affect were not significant. We conclude that sleeping 1.5-2 hours less than usual leads to faster response speed, but more commission errors and decreased positive affect. This indicates that individuals become more impulsive and experience less positive affect after a period of short sleep.

Insomnia as a Partial Mediator of the Relationship Between Personality and Future Symptoms of Anxiety and Depression Among Nurses.

Background: This study investigates insomnia as a partial mediator in the relationship between personality and symptoms of anxiety and depression. Methods: The study is based on partly longitudinal data from the ongoing cohort study "Survey of Shift work, Sleep, and Health" (SUSSH) among Norwegian nurses, a survey examining the work situation and health status of Norwegian nurses measured with annual questionnaires. The present study uses data collected in 2012 (Wave 4), 2013 (Wave 5), and 2014 (Wave 6). The final sample at Wave 6 consisted of 2002 participants, of which 91% were females. The questionnaires included items measuring, among others, demographic variables, work time schedule, insomnia (Bergen Insomnia Scale), personality (Mini-IPIP) and anxiety and depression (Hospital Anxiety and Depression Scale). Results: Extraversion and conscientiousness had no significant direct or indirect association with insomnia, anxiety or depression. Neuroticism and insomnia had direct associations to future symptoms of anxiety and depression. Insomnia was also a significant partial mediator of the relationship between both neuroticism and anxiety, and neuroticism and depression, meaning that neuroticism had an indirect relation to symptoms of anxiety and depression through insomnia. When adjusting for previous symptoms of anxiety and depression at Wave 5, insomnia was no longer a significant mediator between neuroticism and anxiety, and only marginally mediated the relationship between neuroticism and depression. Conclusion: The results showed that insomnia may act as a mediator between neuroticism and symptoms of anxiety and depression, but the indirect relationship between neuroticism and anxiety and depression through insomnia is considerably weaker than the direct association. Hence, the mediating effect of insomnia should be interpreted with caution. The sample mainly consisted of female nurses, and the generalizability of the findings to male dominated occupations is limited. Findings from the present study highlight the importance of an integrated approach and strengthen the understanding of how personality and psychopathology are connected.